Chemoradiation therapy using cyclopamine-loaded liquid–lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles
You J, Zhao J, Wen X, Wu C, Huang Q, Guan F, Wu R, Liang D, Li C. Chemoradiation therapy using cyclopamine-loaded liquid–lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles. Journal Of Controlled Release 2015, 202: 40-48. PMID: 25637565, PMCID: PMC4394992, DOI: 10.1016/j.jconrel.2015.01.031.Peer-Reviewed Original ResearchConceptsCombination therapyHigher antitumor cytotoxicityMurine breast cancerMouse xenograft modelCell linesDesirable pharmacokinetic propertiesChemoradiation therapyTumor sizeTumor responseMouse survivalPancreatic cancerAntitumor cytotoxicitySystemic administrationBreast cancerIntravenous injectionPreclinical studiesTumor relapseRadiation therapyXenograft modelIntratumoral injectionAdenocarcinoma modelTumor growthLower clonogenicityCell responsesTherapy