2023
Dosimetric response of Gafchromic™ EBT‐XD film to therapeutic protons
Guan F, Wang X, Yang M, Draeger E, Han D, Iga K, Guo F, Perles L, Li Y, Sahoo N, Mohan R, Chen Z. Dosimetric response of Gafchromic™ EBT‐XD film to therapeutic protons. Precision Radiation Oncology 2023, 7: 15-26. PMID: 37868341, PMCID: PMC10586355, DOI: 10.1002/pro6.1187.Peer-Reviewed Original ResearchLinear energy transferEBT-XD filmsTherapeutic protonsFilm calibrationProton linear energy transferUltra-high Dose Rate FLASH RadiotherapyDynamic dose rangeMV photon beamDose-averaged LET valuesDose rate dependenceProton beamlineProton beamPhoton beamsFLASH beamSpot scanning proton beamsDosimetric responseLET dependenceFLASH radiotherapyHigh-dose applicationFilm responseLET valuesEnergy transferBeamProtonsGafchromic
2022
Roadmap: helium ion therapy
Mairani A, Mein S, Blakely E, Debus J, Durante M, Ferrari A, Fuchs H, Georg D, Grosshans DR, Guan F, Haberer T, Harrabi S, Horst F, Inaniwa T, Karger CP, Mohan R, Paganetti H, Parodi K, Sala P, Schuy C, Tessonnier T, Titt U, Weber U. Roadmap: helium ion therapy. Physics In Medicine And Biology 2022, 67: 15tr02. PMID: 35395649, DOI: 10.1088/1361-6560/ac65d3.Peer-Reviewed Original ResearchConceptsHelium ion beamHeavy ion therapyIon beam therapyHelium ionsIon beamIon therapyRelative biological effectivenessHeavy ion beamsLawrence Berkeley National LaboratoryCarbon ion beamsHelium ion therapyDifferent particle speciesBerkeley National LaboratoryClinical proton beamsCarbon ion therapyLinear energy transferHigh relative biological effectivenessSharp lateral penumbraHigh penetration depthLateral scatteringNeon ionsBeam therapyProton beamParticle speciesTerms of physics
2020
Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques
Bronk L, Guan F, Patel D, Ma D, Kroger B, Wang X, Tran K, Yiu J, Stephan C, Debus J, Abdollahi A, Jäkel O, Mohan R, Titt U, Grosshans DR. Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques. Cancers 2020, 12: 3658. PMID: 33291477, PMCID: PMC7762185, DOI: 10.3390/cancers12123658.Peer-Reviewed Original ResearchHeidelberg Ion Beam Therapy CenterRelative biological effectivenessCarbon ionsDose-mean lineal energyDose-averaged linear energy transferBiological effectivenessLinear energy transferMonte Carlo systemHelium ionsParticle beamsLineal energyBeam pathBragg peakMaximum relative biological effectivenessEnergy transferProtonsHeliumIonsTherapy CenterBeamExperimental platformSpatial distributionEnergyExperimental resultsSub
2019
Using the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness
Newpower M, Patel D, Bronk L, Guan F, Chaudhary P, McMahon SJ, Prise KM, Schettino G, Grosshans DR, Mohan R. Using the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness. International Journal Of Radiation Oncology • Biology • Physics 2019, 104: 316-324. PMID: 30731186, PMCID: PMC6499683, DOI: 10.1016/j.ijrobp.2019.01.094.Peer-Reviewed Original ResearchConceptsProton energy spectraMicrodosimetric kinetic modelDose-mean lineal energyRelative biological effectivenessProton irradiation experimentsEnergy spectrumLineal energyLineal energy yIrradiation experimentsLineal energy distributionsDose-averaged linear energy transferBiological effectivenessDifferent proton energiesLinear energy transferRBE modelsProton energyBragg curveEnergy distributionGeant4-DNAProton irradiationRBE data
2018
Physical parameter optimization scheme for radiobiological studies of charged particle therapy
Geng C, Gates D, Bronk L, Ma D, Guan F. Physical parameter optimization scheme for radiobiological studies of charged particle therapy. Physica Medica 2018, 51: 13-21. PMID: 30278981, PMCID: PMC6173200, DOI: 10.1016/j.ejmp.2018.06.001.Peer-Reviewed Original ResearchConceptsIon beamParticle therapyPhysical quantitiesDose-averaged linear energy transferC-ion beamsLinear energy transferBiological dose optimizationParticle beamsProton beamBragg curveBragg peakWhole target regionBeamCorresponding physical dataEnergy transferProtonsMonte Carlo simulationsAppropriate biophysical modelSpatial distributionSOBPRadiobiological studiesCarlo simulationsDose spreadIonsLET