2024
Incorporating boron distribution variations in microdosimetric kinetic model-based relative biological effectiveness calculations for boron neutron capture therapy
Li M, Geng C, Han Y, Guan F, Liu Y, Shu D, Tang X. Incorporating boron distribution variations in microdosimetric kinetic model-based relative biological effectiveness calculations for boron neutron capture therapy. Radiation Protection Dosimetry 2024, ncae158. PMID: 39010755, DOI: 10.1093/rpd/ncae158.Peer-Reviewed Original ResearchBiological effects of boron neutron capture therapyCompound biological effectivenessBoron neutron capture therapyCBE valuesNeutron capture therapyBoron distributionRelative biological effectiveness calculationsEnergy spectra of particlesLineal energy spectraSpectrum of particlesEffectiveness of boron neutron capture therapyNucleus radiusBoronMKM modelSurviving fractionRadiusCalculationsDistribution variationBiological effects
2020
Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns
Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Scientific Reports 2020, 10: 3199. PMID: 32081928, PMCID: PMC7035246, DOI: 10.1038/s41598-020-60246-5.Peer-Reviewed Original ResearchConceptsIntensity-modulated proton therapyLow-energy beamsIntensity modulation patternCurrent treatment planProton therapyBiological effectsDelivery strategiesTarget doseTherapeutic indexTreatment planHigh-energy beamsEffective doseEnhanced biological effectClinical potentialTherapyCancer cellsDoseBragg peak