Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration
Tu T, Shi Y, Zhou B, Wang X, Zhang W, Zhou G, Mo X, Wang W, Wu J, Liu W. Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration. Npj Regenerative Medicine 2023, 8: 67. PMID: 38092758, PMCID: PMC10719373, DOI: 10.1038/s41536-023-00341-z.Peer-Reviewed Original ResearchHuman adipose-derived stem cellsExtracellular matrixTenogenic phenotypeCell-substrate adhesionStem cellsTenogenic differentiationCytoskeletal organizationMajor bioactive moleculesPositive regulationRNA sequencingBiological processesMesenchymal stem cellsECM moleculesSpecific differentiationRegulation axisAdipose-derived stem cellsKey moleculesPeptidase activityExpression levelsTendon extracellular matrixInductive mechanismDifferentiationRegulationVital nicheType I collagen