2024
TET3-overexpressing macrophages promote endometriosis
Lv H, Liu B, Dai Y, Li F, Bellone S, Zhou Y, Mamillapalli R, Zhao D, Venkatachalapathy M, Hu Y, Carmichael G, Li D, Taylor H, Huang Y. TET3-overexpressing macrophages promote endometriosis. Journal Of Clinical Investigation 2024, 134: e181839. PMID: 39141428, PMCID: PMC11527447, DOI: 10.1172/jci181839.Peer-Reviewed Original ResearchDisease-associated macrophagesTET3 overexpressionHuman endometriosis lesionsPathophysiology of endometriosisPro-inflammatory cytokine productionChronic inflammatory diseaseReproductive age womenEndometriosis lesionsE3 ubiquitin ligasePathogenic macrophagesCytokine productionEndometriosisInflammatory diseasesTET3 knockdownEndometriosis progressionPathogenic contributorsLet-7 miRNA expressionAge womenMacrophagesMouse macrophagesTherapeutic targetUbiquitin ligaseTET3MiceDisease
2022
The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract
Zhou Y, Gu B, Brichant G, Singh JP, Yang H, Chang H, Zhao Y, Cheng C, Liu ZW, Alderman MH, Lu L, Yang X, Gao XB, Taylor HS. The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract. BMC Biology 2022, 20: 93. PMID: 35491423, PMCID: PMC9059368, DOI: 10.1186/s12915-022-01293-4.Peer-Reviewed Original ResearchConceptsEstrogen receptorMaintenance of pregnancyFetal mouse brainReproductive systemE3 micePregnancy outcomesEstrogen actionEstrogen potencyPregnant miceEstrogen exposureEstrogen signalingFetal developmentMouse brainSteroid hormonesUnexpected functional rolesPregnancyReproductive tractHormone estriolBrainReceptorsExpression levelsFetusesExploratory behaviorMiceNovel mechanism
2010
In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer
Doherty LF, Bromer JG, Zhou Y, Aldad TS, Taylor HS. In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer. Discover Oncology 2010, 1: 146-155. PMID: 21761357, PMCID: PMC3140020, DOI: 10.1007/s12672-010-0015-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzhydryl CompoundsBlotting, WesternCarcinogensCell Line, TumorDiethylstilbestrolEndocrine DisruptorsEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticFemaleGene ExpressionHistone-Lysine N-MethyltransferaseHumansMammary Neoplasms, ExperimentalMicePhenolsPolycomb Repressive Complex 2PregnancyPrenatal Exposure Delayed EffectsReverse Transcriptase Polymerase Chain ReactionConceptsUtero exposureMCF-7 cellsEZH2 expressionMammary tissueMammary glandBreast cancerBreast cancer riskEffects of BPAAdult mammary tissueEZH2 protein expressionPersistent epigenetic changesZeste homolog 2DES exposureFetal exposureEZH2 mRNA expressionBreast neoplasiaNeoplastic changesCancer riskBPA treatmentEndocrine-disrupting chemicalsAdult womenDevelopmental programmingMRNA expressionUteroMice