Featured Publications
Respective Roles of Craniosynostosis and Syndromic Influences on Cranial Fossa Development
Lu X, Forte AJ, Wilson AT, Park KE, Allam O, Alperovich M, Steinbacher DM, Alonso N, Persing JA. Respective Roles of Craniosynostosis and Syndromic Influences on Cranial Fossa Development. Plastic & Reconstructive Surgery 2021, 148: 145-156. PMID: 34181610, DOI: 10.1097/prs.0000000000008101.Peer-Reviewed Original ResearchAirway Growth in Preoperative Patients with Crouzon Syndrome
Lu X, Forte AJ, Park KE, Allam O, Smetona J, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Airway Growth in Preoperative Patients with Crouzon Syndrome. Facial Plastic Surgery & Aesthetic Medicine 2021, 23: 191-197. PMID: 33577380, DOI: 10.1089/fpsam.2020.0441.Peer-Reviewed Original ResearchConceptsYears of ageNasal airway volumeAirway volumeCrouzon syndromePharyngeal airwayCross-sectional areaAirway cross-sectional areaObstructive sleep apneaMonths of agePreoperative patientsSleep apneaMaximal constrictionAirway developmentAirway growthTomography scanAge subgroupsCT scanPatientsSyndromeCrouzon patientsNatural historyAgeNormal dimensionsAirwayMaterialise softwareCranial Fossa Development in Differing Subtypes of Crouzon Syndrome.
Lu X, Forte AJ, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Cranial Fossa Development in Differing Subtypes of Crouzon Syndrome. Journal Of Craniofacial Surgery 2020, 31: 673-677. PMID: 32049910, DOI: 10.1097/scs.0000000000006181.Peer-Reviewed Original Research
2022
Effect of health care disparities on procedure selection of autologous breast reconstruction in Florida.
Huayllani MT, Torres-Guzman RA, Avila FR, Advani PP, Spaulding AC, Cochuyt JJ, Nguyen MT, Lu X, Rinker BD, Forte AJ. Effect of health care disparities on procedure selection of autologous breast reconstruction in Florida. Breast Disease 2022, 41: 75-80. PMID: 34487016, DOI: 10.3233/bd-210004.Peer-Reviewed Original ResearchConceptsAutologous breast reconstructionBreast reconstructionFree flapFlap reconstructionReconstructive surgeryAutologous breast reconstructive surgeryFlorida Inpatient Discharge DatasetPatients 18 yearsBreast reconstructive surgeryMultivariate logistic regressionPedicled flap reconstructionHealth care disparitiesMann-Whitney testHispanic patientsIndependent associationAutologous reconstructionBreast cancerHigher oddsPatientsCare disparitiesPedicled flapsProcedure selectionLogistic regressionPrivate insuranceFlap
2021
The Impact of implant-based reconstruction on persistent pain after breast cancer surgery: A systematic review
Guliyeva G, Torres RA, Avila FR, Kaplan JL, Lu X, Forte AJ. The Impact of implant-based reconstruction on persistent pain after breast cancer surgery: A systematic review. Journal Of Plastic Reconstructive & Aesthetic Surgery 2021, 75: 519-527. PMID: 34801428, DOI: 10.1016/j.bjps.2021.09.079.Peer-Reviewed Original ResearchConceptsBreast cancer surgeryPersistent painCancer surgeryFrequency of analgesicsPlastic surgeonsBreast cancer survivorsFull-text articlesAppropriate reconstruction techniqueCancer survivorsSurgical techniqueImplant reconstructionEligible articlesSystematic reviewPPBCTFinal reviewSame dosagePatientsRelevant articlesIncreased chanceLower chancePainSurgerySurgeonsMost studiesScopus databasesTreatment Contraindications Based on Comorbidity Status in Patients With Melanoma in the United States
Boczar D, Bagaria SP, Spaulding AC, Huayllani MT, Avila FR, Guliyeva G, Lu X, Rinker BD, Forte AJ. Treatment Contraindications Based on Comorbidity Status in Patients With Melanoma in the United States. Anticancer Research 2021, 41: 2067-2070. PMID: 33813415, DOI: 10.21873/anticanres.14976.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseMultivariate logistic regressionComorbid conditionsTreatment contraindicationsGovernment insuranceLogistic regressionUnknown treatment statusMost patientsPatient demographicsComorbidity statusCurative treatmentMelanoma patientsCancer DatabaseIndependent associationOncological patientsMelanoma incidenceTreatment decisionsInclusion criteriaHigher oddsMelanoma treatmentTreatment statusPatientsPoor candidatesPatient treatmentPrivate insuranceConformity of the Virtual Surgical Plan to the Actual Result Comparing Five Craniofacial Procedure Types.
Maniskas S, Pourtaheri N, Chandler L, Lu X, Bruckman KC, Steinbacher DM. Conformity of the Virtual Surgical Plan to the Actual Result Comparing Five Craniofacial Procedure Types. Plastic & Reconstructive Surgery 2021, 147: 915-924. PMID: 33776034, DOI: 10.1097/prs.0000000000007776.Peer-Reviewed Original ResearchConceptsVirtual surgical planningProcedure typeCranial vault remodelingSurgical planningOrthognathic surgeryMandibular distractionVault remodelingMandible reconstructionActual postoperative outcomesVirtual surgical planPostoperative outcomesConsecutive patientsMore predictable resultsSingle surgeonExcellent outcomesTomographic scanSkeletal repositioningPostoperative movementSurgical planBonferroni analysisIntraoperative judgmentIntraoperative guidePermanent implantsPatientsSurgeryAge as a risk factor for breast cancer-related lymphedema: a systematic review
Guliyeva G, Huayllani MT, Boczar D, Avila FR, Lu X, Forte AJ. Age as a risk factor for breast cancer-related lymphedema: a systematic review. Journal Of Cancer Survivorship 2021, 17: 246-253. PMID: 33486706, DOI: 10.1007/s11764-021-00994-z.Peer-Reviewed Original ResearchConceptsCancer-related lymphedemaRisk factorsBreast cancer-related lymphedemaPossible risk factorsLevel of evidenceDevelopment of lymphedemaBCRL developmentEffect of agePatient characteristicsDisease entityOvid MEDLINEAverage ageSystematic reviewMedical literaturePatientsRelevant articlesLymphedemaFinal analysisAgeIndividual studiesDifferent findingsEffect relationshipMethodsPubMedReviewMEDLINEUse of bioimpedance spectroscopy for prospective surveillance and early diagnosis of breast cancer-related lymphedema.
Forte AJ, Huayllani MT, Boczar D, Avila FR, Kassis S, Ciudad P, Lu X, Moore PA, McLaughlin SA. Use of bioimpedance spectroscopy for prospective surveillance and early diagnosis of breast cancer-related lymphedema. Breast Disease 2021, 40: 85-93. PMID: 33646139, DOI: 10.3233/bd-201008.Peer-Reviewed Original ResearchConceptsBreast cancer-related lymphedemaChronic breast cancer-related lymphedemaCancer-related lymphedemaEarly diagnosisProspective surveillanceBioimpedance analysisEmbase databasesOvid MEDLINEBioimpedance spectroscopyL-Dex scoresEnglish-language studiesVolume of lymphedemaRetrospective studyLymphedema patientsHealthy participantsDiagnosisLymphedemaDemonstrated benefitsPatientsDiagnostic toolMEDLINEPubMedSurveillanceBioimpedanceOutcomes
2020
Younger Age as a Risk Factor for Gynecologic Cancer–related Lymphedema: A Systematic Review
Guliyeva G, Huayllani MT, Avila FR, Boczar D, Lu X, Forte AJ. Younger Age as a Risk Factor for Gynecologic Cancer–related Lymphedema: A Systematic Review. Anticancer Research 2020, 40: 6609-6612. PMID: 33288555, DOI: 10.21873/anticanres.14685.Peer-Reviewed Original ResearchConceptsGynecologic cancerLower limb lymphedemaYounger ageRisk factorsLimb lymphedemaCancer-related lymphedemaImpact of ageHazard ratioLymphedema developmentOdds ratioOutcome measuresEarly diagnosisSystematic reviewOlder ageLymphedemaCancerRelevant articlesIndividual studiesAgeTreatmentSignificant relationshipMorbidityRisk assessmentDistinguishing Craniomorphometric Characteristics of Unilateral Lambdoid Craniosynostosis.
Allam O, Park KE, Pourtaheri N, Mozaffari MA, Smetona J, Lu X, Ahmad M, Persing JA, Alperovich M. Distinguishing Craniomorphometric Characteristics of Unilateral Lambdoid Craniosynostosis. Journal Of Craniofacial Surgery 2020, 32: 125-129. PMID: 33156173, DOI: 10.1097/scs.0000000000007098.Peer-Reviewed Original ResearchConceptsUnilateral lambdoid synostosisUL patientsDeformational plagiocephalySingle-suture nonsyndromic craniosynostosisPosterior deformational plagiocephalyUnilateral lambdoid craniosynostosisDP patientsClinical findingsPathological characteristicsRare formPatientsAnterior midlineLambdoid craniosynostosisMajority maleCT imagingLambdoid synostosisNonsyndromic craniosynostosisReliable indicatorSignificant differencesLambdoid sutureSide earCraniosynostosisScansEarPatient scansA Systematic Review of Peripheral Neuropathies in Breast Cancer–Related Lymphedema
Forte AJ, Huayllani MT, Boczar D, Manrique OJ, Lu X, McLaughlin SA, Kung TA. A Systematic Review of Peripheral Neuropathies in Breast Cancer–Related Lymphedema. Hand 2020, 17: 668-675. PMID: 33073616, PMCID: PMC9274882, DOI: 10.1177/1558944720963944.Peer-Reviewed Original ResearchConceptsBreast cancer-related lymphedemaCarpal tunnel syndromePeripheral neuropathyCarpal tunnel releaseNeuropathic painBreast cancerSecondary lymphedemaSystematic reviewWorsening of lymphedemaControlled Trials databasesCochrane Central RegisterCancer-related lymphedemaNon-Indexed CitationsDevelopment of lymphedemaBrachial plexopathyCentral RegisterTrials databasesSafe procedureTunnel syndromeCause-effect associationIn-ProcessEpub AheadOvid MEDLINEInclusion criteriaNeuropathyWhat Is the Difference in Cranial Base Morphology in Isolated and Syndromic Bicoronal Synostosis?
Lu X, Forte AJ, Wilson AT, Park KE, Allam O, Mozaffari MA, Alperovich M, Steinbacher DM, Alonso N, Persing JA. What Is the Difference in Cranial Base Morphology in Isolated and Syndromic Bicoronal Synostosis? Plastic & Reconstructive Surgery 2020, 146: 599-610. PMID: 32842109, DOI: 10.1097/prs.0000000000007068.Peer-Reviewed Original ResearchCranial Fossa Volume and Morphology Development in Apert Syndrome.
Lu X, Forte AJ, Wilson A, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Cranial Fossa Volume and Morphology Development in Apert Syndrome. Plastic & Reconstructive Surgery 2020, 145: 790e-802e. PMID: 32221226, DOI: 10.1097/prs.0000000000006679.Peer-Reviewed Original ResearchFinite-Element Biomechanical-Simulated Analysis of the Nasolabial Fold.
Chen G, Lu X, Yin N. Finite-Element Biomechanical-Simulated Analysis of the Nasolabial Fold. Journal Of Craniofacial Surgery 2020, 31: 492-496. PMID: 31842067, DOI: 10.1097/scs.0000000000006063.Peer-Reviewed Original ResearchConceptsFinite element analysisFEA modelFEA simulationABAQUS softwareForce loadingComputer-aided design modelEngineering design moduleStudy of deformationBetter biomechanical propertiesHypermesh softwareMaterial propertiesBiomechanical simulationElement typesCAD modelGeomagic StudioDesign moduleBiomechanical modelInteractive application softwareDesign modelBiomechanical propertiesGeometrical resemblanceBiomechanical analysisLoadingSimulationsComputer-AidedNational Analysis of Patients With Ulcerated Melanoma in the United States
Boczar D, Sisti A, Restrepo DJ, Huayllani MT, Manrique OJ, Lu X, Spaulding AC, Bagaria SP, Parker AS, Forte AJ. National Analysis of Patients With Ulcerated Melanoma in the United States. Anticancer Research 2020, 40: 1055-1058. PMID: 32014953, DOI: 10.21873/anticanres.14042.Peer-Reviewed Original ResearchConceptsUlcerated melanomaNational Cancer DatabaseNon-white patientsNon-white raceZip codesYears of agePatient disparitiesPatient demographicsMelanoma patientsTumor characteristicsMale sexUnfavorable prognosisCancer DatabaseHigher oddsLower oddsPatientsMelanomaUlcerationFacility characteristicsLower educationOddsLow incomeEducation levelUrban countiesPresent studyPaget disease of the breast: A national retrospective analysis of the US population
Sisti A, Huayllani MT, Restrepo DJ, Boczar D, Advani P, Lu X, Spaulding AC, Ball CT, McLaughlin SA, Forte AJ. Paget disease of the breast: A national retrospective analysis of the US population. Breast Disease 2020, 39: 119-126. PMID: 32390594, DOI: 10.3233/bd-200439.Peer-Reviewed Original ResearchConceptsNational Cancer DatabasePaget's diseaseComplete mastectomyPartial mastectomyCommon treatmentSurvival rateRegional lymph node metastasisBlack race/ethnicityHigher cancer stageNational retrospective analysisOverall survival rateLymph node metastasisLarger tumor sizeHigh tumor gradeRace/ethnicityMedian ageNode metastasisFemale patientsShorter survivalTumor sizeCancer DatabaseCancer stageTumor gradeTreatment characteristicsMetastatic cancerSMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis.
Wu RT, Timberlake AT, Abraham PF, Gabrick KS, Lu X, Peck CJ, Sawh-Martinez RF, Steinbacher DM, Alperovich MA, Persing JA. SMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis. Plastic & Reconstructive Surgery 2020, 145: 117e-125e. PMID: 31592950, DOI: 10.1097/prs.0000000000006319.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChildChild BehaviorChild DevelopmentChild, PreschoolCraniosynostosesCraniotomyDevelopmental DisabilitiesDouble-Blind MethodFemaleFollow-Up StudiesHumansInfantIntelligence TestsLoss of Function MutationMalePlastic Surgery ProceduresProspective StudiesSkullSmad6 ProteinTreatment Outcome
2019
What Factors Define Limb Salvage or Amputation Surgery in Osteosarcoma of the Upper Extremities?
Huayllani MT, Restrepo DJ, Boczar D, Sisti A, Spaulding AC, Parker AS, Manrique OJ, Lu X, Wilke BK, Forte AJ. What Factors Define Limb Salvage or Amputation Surgery in Osteosarcoma of the Upper Extremities? Anticancer Research 2019, 39: 6807-6811. PMID: 31810946, DOI: 10.21873/anticanres.13896.Peer-Reviewed Original ResearchConceptsUpper extremityLimb salvageLimb amputationMultivariate logistic regression modelNational Cancer DatabaseStage IV diseaseLogistic regression modelsChi-squared testAmputation surgeryCancer DatabaseInclusion criteriaStage IVPatientsAmputationOsteosarcomaDescriptive studyExtremitiesSurgerySalvageDiseaseRegression modelsStatistical analysisAnalysis of Melanoma in African American Patients in the United States
Boczar D, Restrepo DJ, Sisti A, Huayllani MT, Saleem HY, Lu X, Cinotto G, Manrique OJ, Spaulding AC, Forte AJ. Analysis of Melanoma in African American Patients in the United States. Anticancer Research 2019, 39: 6333-6337. PMID: 31704864, DOI: 10.21873/anticanres.13844.Peer-Reviewed Original ResearchConceptsAfrican American patientsAA patientsAmerican patientsTumor stagingWorse tumor stagingNational Cancer DatabaseAmerican Joint CommitteePresence of ulcerationAA raceTreatment delayAnalysis of melanomaCancer DatabaseCancer programsCancer stagePatient efficacyPatientsJoint CommitteeMelanomaMean timeTreatmentStagingCaucasiansDaysUnited StatesUlceration