2023
Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials
Zinter M, Markovic D, Asaro L, Nadkarni V, McQuillen P, Sinha P, Matthay M, Jeschke M, Agus M, Sapru A, Agus M, Coughlin-Wells K, Hughes K, French J, Fitzgerald M, Srinivasan V, Sisko M, Chima R, Howard K, Jones R, Thomas N, Spear D, Li S, Pinto A, Eldridge P, Newth C, Kwok J, Hassinger A, Qiao H, Bysani K, Monjure T, Faustino E, Tala J, Kandil S, Quinn T, Hirshberg E, Lilley J, Wintergerst K, Sullivan J, Lee K, Schwarz A, Flores C, Vargas-Shiraishi O, Sorce L, Marsillio L, Shukla A, Cvijanovich N, Flori H, Brumfield B, Stone C, Dahmer M, Jayachandran C, Federman M, Wong K, Vangala S, Pellegrini M, Balliu B, Gala K, Kirkpatrick T, Deshmukh T, Mareboina M, Do N, Ashtari N, Ratiu A, Nett S, Singleton M, Jarvis D, McNally M, Martini K, Pinto N, Chong G, Rodgers C, Viteri S, John R, Mulholland T, Pellicciotti G, Sapru A, McQuillen P, Zinter M, Goel S, Alkhouli M, McKenzie A, Villarreal-Chico D. Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 945-949. PMID: 36656551, PMCID: PMC10111993, DOI: 10.1164/rccm.202210-1988le.Peer-Reviewed Original Research
2020
Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control
Biagas K, Hinton V, Hasbani N, Luckett P, Wypij D, Nadkarni V, Agus M, investigators H, Srinivasan V, Mourani P, Chima R, Thomas N, Li S, Pinto A, Newth C, Hassinger A, Bysani K, Rehder K, Faustino E, Kandil S, Hirshberg E, Wintergerst K, Schwarz A, Bagdure D, Marsillio L, Cvijanovich N, Pham N, Quasney M, Flori H, Federman M, Nett S, Pinto N, Viteri S, Schneider J, Medar S, Sapru A, McQuillen P, Babbitt C, Lin J, Jouvet P, Yanay O, Allen C, Asaro L, Coughlin-Wells K, French J, Natarajan A, Network T. Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control. The Journal Of Pediatrics 2020, 218: 57-63.e5. PMID: 31910992, PMCID: PMC7122648, DOI: 10.1016/j.jpeds.2019.10.055.Peer-Reviewed Original ResearchConceptsHealth-related qualityHigher-target groupGlycemic controlLife outcomesIll childrenPediatric QualityProspective longitudinal cohort studyIntensive care dischargeTarget glycemic controlTight glycemic controlLongitudinal cohort studyRisk of mortalityLack of benefitRespiratory failureCohort studyHospital dischargeInsulin titrationSecondary outcomesPrimary outcomeCare dischargeEligible childrenChild Behavior ChecklistOverall healthTotal healthVineland Adaptive Behavior Scales
2017
Tight Glycemic Control in Critically Ill Children
Agus M, Wypij D, Hirshberg E, Srinivasan V, Faustino E, Luckett P, Alexander J, Asaro L, Curley M, Steil G, Nadkarni V. Tight Glycemic Control in Critically Ill Children. New England Journal Of Medicine 2017, 376: 729-741. PMID: 28118549, PMCID: PMC5444653, DOI: 10.1056/nejmoa1612348.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood GlucoseCardiovascular Surgical ProceduresChildChild, PreschoolCritical IllnessFemaleGlucoseHospital MortalityHumansHyperglycemiaHypoglycemic AgentsInfantInfant, NewbornInsulinIntensive Care Units, PediatricIntention to Treat AnalysisLength of StayMalePostoperative PeriodConceptsHigher-target groupLower-target groupTight glycemic controlBlood glucose levelsGlycemic controlIll childrenGlucose levelsCardiac surgeryHealth care-associated infectionsICU-free daysVentilator-free daysCritically Ill ChildrenNormal blood glucose levelsIntensive care unitCare-associated infectionsSafety monitoring boardAverage glucose levelsHigh rateContinuous glucose monitoringIll adultsOrgan dysfunctionPrimary outcomeSevere hypoglycemiaTreat analysisCare unit
2014
Assessing the benefits and risks of tight glycemic control in critically ill children
Faustino E, Kandil S. Assessing the benefits and risks of tight glycemic control in critically ill children. Pediatric Health Medicine And Therapeutics 2014, Volume 5: 93-98. DOI: 10.2147/phmt.s50410.Peer-Reviewed Original ResearchTight glycemic controlIntensive care unitIll childrenGlycemic controlCare unitSurgical intensive care unitSubsequent multicenter trialSingle-center trialInsulin-induced hypoglycemiaIntravenous insulinCenter trialIll adultsIll patientsMulticenter trialTrialsHypoglycemiaChildrenHigh rateMortalityCurrent literatureInsulinRiskHyperglycemiaPatientsHyperglycemia, Dysglycemia and Glycemic Control in Pediatric Critical Care
Agus M, Faustino E, Rigby M. Hyperglycemia, Dysglycemia and Glycemic Control in Pediatric Critical Care. 2014, 93-101. DOI: 10.1007/978-1-4471-6416-6_8.Peer-Reviewed Original ResearchGlycemic controlPediatric practitionersPoor outcomeProspective studyOrgan support measuresPediatric-specific dataPediatric-specific protocolsMore definitive dataHigher illness severityPediatric critical careInternational consensus statementProspective trialGlycemic managementIll patientsPediatric ICUIllness severityHigh morbidityHypoglycemic ratePatient populationPediatric intensivistsPediatric studiesSevere illnessIll childrenConsensus statementCritical care