2022
Effect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults
Shlipak M, Sheshadri A, Hsu F, Chen S, Jotwani V, Tranah G, Fielding R, Liu C, Ix J, Coca S, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Leeuwenburgh J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Beard V, Tsiroyannis E, Hau C, Manini T, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rushing J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Sweeney Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Hankinson J, Vaz Fragoso C, Groessl E, Kaplan R. Effect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults. JAMA Internal Medicine 2022, 182: 650-659. PMID: 35499834, PMCID: PMC9062767, DOI: 10.1001/jamainternmed.2022.1449.Peer-Reviewed Original ResearchConceptsKidney function declineExercise interventionSedentary older adultsPhysical activityFunction declineOlder adultsClinical trialsHealth education control interventionModerate-intensity physical activityModerate-intensity exercise interventionAncillary analysisGlomerular filtration rateRandomized clinical trialsHigh physical activityModerate-intensity exerciseModerate-intensity activityCystatin C changesLifestyle interventionPrimary outcomeLarge trialsMean ageFiltration rateModerate exerciseOriginal trialMAIN OUTCOME
2019
Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability
Glynn N, Gmelin T, Santanasto A, Lovato L, Lange‐Maia B, Nicklas B, Fielding R, Manini T, Myers V, Rekeneire N, Spring B, Pahor M, King A, Rejeski W, Newman A, Pahor M, Guralnik J, Anton S, Buford T, Leeuwenburgh C, Nayfield S, Manini T, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Joyce K, Lovato L, Pierce J, Roberson W, Robertson J, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Chen S, Pierce J, Chen H, Hadley E, Romashkan S, Patel K, Bethesda, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor‐Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Yank V, Berra K, Bell C, Thiessen R, Youngman K, Virgen S, Maldonado E, Tarin K, Klaftenegger H, Prosak C, Campero I, Garcia D, Soto J, Chio L, Hoskins D, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Krol J, Beard V, Tsiroyannis E, Hau C, Manini T, Pahor M, Anton S, Buford T, Marsiske M, Nayfield S, Sandesara B, Black M, Burk W, Hoover B, Knaggs J, Marena W, Korytov I, Curtis S, Lorow M, Goswami C, Lewis M, Kamen M, Bitz J, Stanton B, Hicks T, Gay C, Xie C, Morris H, Singletary F, Causer J, Yonce S, Radcliff K, Smith M, Scott J, Rodriguez M, Fitch M, Dunn M, Schllesinger J, Newman A, Studenski S, Goodpaster B, Lopez O, Glynn N, Nadkarni N, Ives D, Newman M, Grove G, Williams K, Bonk J, Rush J, Kost P, Vincent P, Gerger A, Romeo J, Monheim L, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer‐Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, Rekeneire N, McGloin J, Mautner R, Huie‐White S, Bianco L, Zocher J, Wu K, Shepard D, Fennelly B, Castro R, Halpin S, Brennan M, Barnett T, Iannone L, Zenoni M, Bugaj J, Bailey C, Charpentier P, Hawthorne‐Jones G, Mignosa B, Lewis L, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Vaz Fragoso C, Groessl E, Kaplan R. Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability. Journal Of The American Geriatrics Society 2019, 68: 619-624. PMID: 31867713, PMCID: PMC8061638, DOI: 10.1111/jgs.16274.Peer-Reviewed Original ResearchConceptsPersistent major mobility disabilityMajor mobility disabilityStructured PA interventionPhysical activity interventionsBaseline fatiguePA interventionsMobility disabilityActivity interventionsRisk of MMDHealth educationIncident major mobility disabilityModerate-intensity PA interventionHigher baseline fatigueProportional hazards modelSelf-reported fatigueYears of ageLifestyle interventionProspective cohortElders StudyHazards modelLower riskStudy participantsMore fatigueLess fatiguePast week
2017
Association of Accelerometry‐Measured Physical Activity and Cardiovascular Events in Mobility‐Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study
Cochrane S, Chen S, Fitzgerald J, Dodson J, Fielding R, King A, McDermott M, Manini T, Marsh A, Newman A, Pahor M, Tudor‐Locke C, Ambrosius W, Buford T, Espeland M, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Pierce J, Romashkan S, Patel K, Bonds D, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Butitta B, Donatto S, Cocreham S, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Anton S, Nayfield S, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer‐Skinner R, Wrights A, Fries R, Barr D, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Handberg E, Flynn G, Gill T, Hankinson J, Fragoso C, Kaplan R. Association of Accelerometry‐Measured Physical Activity and Cardiovascular Events in Mobility‐Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study. Journal Of The American Heart Association 2017, 6: e007215. PMID: 29197830, PMCID: PMC5779035, DOI: 10.1161/jaha.117.007215.Peer-Reviewed Original ResearchMeSH KeywordsActigraphyAge FactorsAgedAged, 80 and overAgingCardiovascular DiseasesExerciseExercise TherapyFemaleFitness TrackersGeriatric AssessmentHealth Knowledge, Attitudes, PracticeHumansIncidenceMaleMobility LimitationPatient Education as TopicPredictive Value of TestsPrognosisProtective FactorsRisk FactorsRisk Reduction BehaviorTime FactorsUnited StatesConceptsCardiovascular eventsPhysical activityOlder adultsLower incidenceLower cardiovascular event ratesCardiovascular event ratesCardiovascular risk factorsSubsequent cardiovascular eventsMedical record reviewHealth education interventionHip-worn accelerometersPhysical activity surveillanceLife Study participantsMonths postrandomizationLife studiesRecord reviewRisk factorsDaily PAStudy participantsEvent ratesMobility limitationsEducation interventionLongitudinal associationsBaselineActivity surveillanceThe effect of intervening hospitalizations on the benefit of structured physical activity in promoting independent mobility among community-living older persons: secondary analysis of a randomized controlled trial
Gill TM, Beavers DP, Guralnik JM, Pahor M, Fielding RA, Hauser M, Manini TM, Marsh AP, McDermott MM, Newman AB, Allore HG, Miller ME, for the LIFE Study Investigators. The effect of intervening hospitalizations on the benefit of structured physical activity in promoting independent mobility among community-living older persons: secondary analysis of a randomized controlled trial. BMC Medicine 2017, 15: 65. PMID: 28347337, PMCID: PMC5368996, DOI: 10.1186/s12916-017-0824-6.Peer-Reviewed Original ResearchConceptsMajor mobility disabilityPhysical activity programPhysical activity interventionsPhysical activityActivity programOlder personsHazard ratioActivity interventionsFunctional limitationsModerate-intensity physical activity programCommunity-living older personsStructured physical activity programHealth education groupStructured physical activityHealth education programsIndependent mobilityAcute illnessLifestyle interventionHospital exposureElders StudyParallel groupSedentary personsUS CentersHospitalizationSustained benefit
2016
Effect of Structured Physical Activity on Overall Burden and Transitions Between States of Major Mobility Disability in Older Persons: Secondary Analysis of a Randomized Trial.
Gill TM, Guralnik JM, Pahor M, Church T, Fielding RA, King AC, Marsh AP, Newman AB, Pellegrini CA, Chen SH, Allore HG, Miller ME. Effect of Structured Physical Activity on Overall Burden and Transitions Between States of Major Mobility Disability in Older Persons: Secondary Analysis of a Randomized Trial. Annals Of Internal Medicine 2016, 165: 833-840. PMID: 27669457, PMCID: PMC5476905, DOI: 10.7326/m16-0529.Peer-Reviewed Original ResearchConceptsMajor mobility disabilityStructured physical activity programPhysical activity programPhysical activityMobility disabilityHealth educationActivity programStructured physical activityHealth education interventionNational InstituteOnset of disabilityQuality of lifeDisability episodeTreat principleRandomized trialsPatient assessmentRisk ratioOverall burdenProportion of assessmentsSedentary personsFunctional limitationsU.S. CentersEnhanced recoverySecondary analysisOlder personsPredictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study
Layne AS, Hsu FC, Blair SN, Chen SH, Dungan J, Fielding RA, Glynn NW, Hajduk AM, King AC, Manini TM, Marsh AP, Pahor M, Pellegrini CA, Buford TW, Investigators L, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kim W, Beard V, Manini T, Pahor M, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study. Archives Of Physical Medicine And Rehabilitation 2016, 98: 11-24.e3. PMID: 27568165, PMCID: PMC5183463, DOI: 10.1016/j.apmr.2016.07.019.Peer-Reviewed Original ResearchConceptsPhysical functionPhysical activitySPPB scoreGait speedHigher self-reported physical activityShort Physical Performance Battery scorePhysical activity-related factorsPhysical Performance Battery scoreLower body mass indexModerate-intensity physical activitySelf-reported physical activityOlder adultsBaseline physical functionBody mass indexLower extremity functionStructured physical activityHome-based sessionsHealth education programsActivity-related factorsPredictors of changeMulticenter institutionsLifestyle interventionRelevant health informationBaseline factorsLife studies
2014
Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults: The LIFE Study Randomized Clinical Trial
Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD. Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults: The LIFE Study Randomized Clinical Trial. JAMA 2014, 311: 2387-2396. PMID: 24866862, PMCID: PMC4266388, DOI: 10.1001/jama.2014.5616.Peer-Reviewed Original ResearchConceptsMajor mobility disabilityPhysical activity groupModerate-intensity physical activity programHealth education groupPhysical activity programHealth education programsMobility disabilityOlder adultsActivity programClinical trialsActivity groupPhysical activityIncident major mobility disabilityShort Physical Performance BatteryPersistent mobility disabilityPhysical activity preventsEducation groupSerious adverse eventsIndependent risk factorPhysical Performance BatteryDefinitive clinical trialsStructured physical activityVulnerable older adultsAdverse eventsLifestyle intervention
2006
Effects of a Physical Activity Intervention on Measures of Physical Performance: Results of the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Study
Pahor M, Blair S, Espeland M, Fielding R, Gill T, Guralnik J, Hadley E, King A, Kritchevsky S, Maraldi C, Miller M, Newman A, Rejeski W, Romashkan S, Studenski S. Effects of a Physical Activity Intervention on Measures of Physical Performance: Results of the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Study. The Journals Of Gerontology Series A 2006, 61: 1157-1165. PMID: 17167156, DOI: 10.1093/gerona/61.11.1157.Peer-Reviewed Original ResearchConceptsShort Physical Performance BatteryPhysical activity interventionsSPPB scoreMobility disabilityActivity interventionsPA interventionsPA groupBaseline short physical performance batteryComprehensive physical activity interventionModerate-intensity PA interventionElders Pilot StudyStructured PA interventionPhysical performanceDaily living (ADL) disabilityMajor mobility disabilityPhysical Performance BatteryHealth education interventionPhysical performance measuresDistal health outcomesLifestyle interventionSPPB performanceMore distal health outcomesLower incidenceSedentary personsPerformance Battery
2000
Role of Exercise Stress Testing and Safety Monitoring for Older Persons Starting an Exercise Program
Gill TM, DiPietro L, Krumholz HM. Role of Exercise Stress Testing and Safety Monitoring for Older Persons Starting an Exercise Program. JAMA 2000, 284: 342-349. PMID: 10891966, DOI: 10.1001/jama.284.3.342.Peer-Reviewed Original ResearchConceptsExercise stress testingAdverse cardiac eventsExercise programOlder personsCardiac eventsStress testingPhysical activityRoutine exercise stress testingSedentary older personsSymptomatic cardiovascular diseasePharmacological stress testingCurrent physician practiceRelative exercise intensityMajority of personsUnproven benefitPhysical functionCurrent guidelinesCardiovascular diseaseExercise intensityPhysician practicesSafety monitoringRiskExercisePersonsTesting