2013
Bayesian Estimation of Mixture Models with Prespecified Elements to Compare Drug Resistance in Treatment-Naïve and Experienced Tuberculosis Cases
Izu A, Cohen T, DeGruttola V. Bayesian Estimation of Mixture Models with Prespecified Elements to Compare Drug Resistance in Treatment-Naïve and Experienced Tuberculosis Cases. PLOS Computational Biology 2013, 9: e1002973. PMID: 23555210, PMCID: PMC3605089, DOI: 10.1371/journal.pcbi.1002973.Peer-Reviewed Original ResearchConceptsTreatment-experienced patientsDrug-resistant strainsMultiple drug-resistant strainsTreatment-naïve patientsDrug-resistant tuberculosisMycobacterium tuberculosis isolatesWorld Health OrganizationDrug resistance pathwaysTreatment-naïveTuberculosis casesTuberculosis isolatesWorldwide surveillanceDrug resistancePatientsHealth OrganizationResistant strainsResistant pathogensResistance pathwaysLow transmissibilityPathwayTuberculosis
2009
What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae?
Colijn C, Cohen T, Fraser C, Hanage W, Goldstein E, Givon-Lavi N, Dagan R, Lipsitch M. What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae? Journal Of The Royal Society Interface 2009, 7: 905-919. PMID: 19940002, PMCID: PMC2871802, DOI: 10.1098/rsif.2009.0400.Peer-Reviewed Original ResearchConceptsDrug-resistant strainsStreptococcus pneumoniaeInfectious diseasesDrug-susceptible strainsHigher reproduction numberCent prevalenceSubstantial prevalencePersistent coexistenceDrug resistanceMultiple infectionsAntimicrobial useResistant strainsBacterial spreadAntimicrobial resistancePrevalenceDiseasePneumoniaeOutcomesReproduction numberTreatmentHost interactionsPathogensCoinfection
2008
Latent Coinfection and the Maintenance of Strain Diversity
Colijn C, Cohen T, Murray M. Latent Coinfection and the Maintenance of Strain Diversity. Bulletin Of Mathematical Biology 2008, 71: 247. PMID: 19082663, PMCID: PMC2652765, DOI: 10.1007/s11538-008-9361-y.Peer-Reviewed Original Research
2007
Antiviral Resistance and the Control of Pandemic Influenza
Lipsitch M, Cohen T, Murray M, Levin BR. Antiviral Resistance and the Control of Pandemic Influenza. PLOS Medicine 2007, 4: e15. PMID: 17253900, PMCID: PMC1779817, DOI: 10.1371/journal.pmed.0040015.Peer-Reviewed Original ResearchConceptsResistant strainsPandemic influenzaInfluenza pandemicAntiviral resistanceTransmission-reducing measuresNext influenza pandemicAntiviral drug useUse of antiviralsStrains of influenzaSuboptimal vaccinesAntiviral treatmentInfluenza infectionRisk of resistanceDeterministic compartmental modelAntiviral agentsAntiviral drugsPandemic planningDrug useVaccine developmentDrug resistanceControl measuresAntiviralsInfluenzaPandemic spreadPandemic