2013
Community-Wide Isoniazid Preventive Therapy Drives Drug-Resistant Tuberculosis: A Model-Based Analysis
Mills HL, Cohen T, Colijn C. Community-Wide Isoniazid Preventive Therapy Drives Drug-Resistant Tuberculosis: A Model-Based Analysis. Science Translational Medicine 2013, 5: 180ra49. PMID: 23576815, PMCID: PMC3714172, DOI: 10.1126/scitranslmed.3005260.Peer-Reviewed Original ResearchConceptsDrug-resistant TBIPT interventionDrug-sensitive infectionsIsoniazid-resistant TBHIV/TBRisk of progressionHigh HIV prevalenceDrug-resistant diseaseIsoniazid-resistant Mycobacterium tuberculosisSymptom-free individualsSignificant elevated riskDrug-resistant strainsWorld Health OrganizationActive TBTB controlResistant tuberculosisHIV prevalenceTuberculosis controlIPT programElevated riskHost immunityMycobacterium tuberculosisHealth OrganizationSelective suppressionIntervention
2012
Population Health Impact and Cost-Effectiveness of Tuberculosis Diagnosis with Xpert MTB/RIF: A Dynamic Simulation and Economic Evaluation
Menzies NA, Cohen T, Lin HH, Murray M, Salomon JA. Population Health Impact and Cost-Effectiveness of Tuberculosis Diagnosis with Xpert MTB/RIF: A Dynamic Simulation and Economic Evaluation. PLOS Medicine 2012, 9: e1001347. PMID: 23185139, PMCID: PMC3502465, DOI: 10.1371/journal.pmed.1001347.Peer-Reviewed Original ResearchConceptsMultidrug-resistant TBCost-effectiveness ratioInitial diagnosisXpert MTB/RIF testMTB/RIF testXpert MTB/RIFIntroduction of XpertTB natural historyTB-HIV coinfectionMultidrug-resistant tuberculosisHigh HIV prevalenceMTB/RIFHealth system costsImplementation of XpertHealth impactsPopulation health impactCost-effectiveness resultsLong-term transmission dynamicsWorld Health OrganizationAntiretroviral therapyTB casesTB deathsTB morbidityHIV prevalenceRIF test
2010
The Prevalence and Drug Sensitivity of Tuberculosis among Patients Dying in Hospital in KwaZulu-Natal, South Africa: A Postmortem Study
Cohen T, Murray M, Wallengren K, Alvarez GG, Samuel EY, Wilson D. The Prevalence and Drug Sensitivity of Tuberculosis among Patients Dying in Hospital in KwaZulu-Natal, South Africa: A Postmortem Study. PLOS Medicine 2010, 7: e1000296. PMID: 20582324, PMCID: PMC2889914, DOI: 10.1371/journal.pmed.1000296.Peer-Reviewed Original ResearchConceptsTime of deathTuberculosis treatmentLimited autopsiesM. tuberculosisMultidrug-resistant bacilliCulture-positive tuberculosisInitiation of treatmentMultidrug-resistant tuberculosisHIV-positive individualsMajority of decedentsRespiratory tract secretionsHigh HIV prevalenceSecond-line antibioticsNeedle core biopsySingle public hospitalDiagnosis of tuberculosisAcid-fast bacilliCause of deathNew public health approachPublic health approachMagnitude of deathsFatal courseAdult inpatientsStudy cohortHIV prevalence