2023
Transmission modeling to infer tuberculosis incidence prevalence and mortality in settings with generalized HIV epidemics
Dodd P, Shaweno D, Ku C, Glaziou P, Pretorius C, Hayes R, MacPherson P, Cohen T, Ayles H. Transmission modeling to infer tuberculosis incidence prevalence and mortality in settings with generalized HIV epidemics. Nature Communications 2023, 14: 1639. PMID: 36964130, PMCID: PMC10037365, DOI: 10.1038/s41467-023-37314-1.Peer-Reviewed Original ResearchConceptsHigh HIV prevalence settingsEstimation of burdenHIV prevalence settingsGeneralized HIV epidemicsTB transmission modelAntiretroviral therapyTB infectionTB incidenceHIV prevalenceTB prevalencePrevalence settingsTB epidemicHIV epidemicHigh burdenBurden estimatesNotification dataAnnual riskSingle pathogenIntervention impactTherapy effectsTuberculosisPrevalenceEpidemicBurdenAfrican countries
2022
A spatial-mechanistic model to estimate subnational tuberculosis burden with routinely collected data: An application in Brazilian municipalities
Chitwood M, Alves L, Bartholomay P, Couto R, Sanchez M, Castro M, Cohen T, Menzies N. A spatial-mechanistic model to estimate subnational tuberculosis burden with routinely collected data: An application in Brazilian municipalities. PLOS Global Public Health 2022, 2: e0000725. PMID: 36962578, PMCID: PMC10021638, DOI: 10.1371/journal.pgph.0000725.Peer-Reviewed Original ResearchPerson/yearTB incidenceCase notificationBurden estimatesIncident TB casesTB case notificationTB control strategiesDisease burden estimatesIncident TBUntreated TBTB casesTuberculosis burdenDisease burdenIncidence rateCase detectionRoutine dataDeath recordsMortality dataIncidenceSubnational estimatesDisease control resourcesBurdenHigh needTBFraction of individuals
2021
Lifetime burden of disease due to incident tuberculosis: a global reappraisal including post-tuberculosis sequelae
Menzies NA, Quaife M, Allwood BW, Byrne AL, Coussens AK, Harries AD, Marx FM, Meghji J, Pedrazzoli D, Salomon JA, Sweeney S, van Kampen SC, Wallis RS, Houben RMGJ, Cohen T. Lifetime burden of disease due to incident tuberculosis: a global reappraisal including post-tuberculosis sequelae. The Lancet Global Health 2021, 9: e1679-e1687. PMID: 34798027, PMCID: PMC8609280, DOI: 10.1016/s2214-109x(21)00367-3.Peer-Reviewed Original ResearchConceptsPost-tuberculosis sequelaeBurden estimatesTuberculosis diseaseDisease episodesIncident tuberculosisIncident tuberculosis casesIncident tuberculosis diseaseNon-fatal health lossOverall disease burdenPulmonary tuberculosis diseaseLifetime health outcomesDisease burden estimatesElevated mortality riskHigh incidence rateExtrapulmonary diseaseLung functionCase fatalityHIV statusLifetime burdenTuberculosis casesTotal DALYsDisease burdenIncidence rateHypothetical cohortTuberculosis survivors