2017
Generating diversity in human glucocorticoid signaling through a racially diverse polymorphism in the beta isoform of the glucocorticoid receptor
Whirledge SD, Jewell CM, Barber LM, Xu X, Katen KS, Garantziotis S, Cidlowski JA. Generating diversity in human glucocorticoid signaling through a racially diverse polymorphism in the beta isoform of the glucocorticoid receptor. Laboratory Investigation 2017, 97: 1282-1295. PMID: 28759007, PMCID: PMC5759773, DOI: 10.1038/labinvest.2017.76.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated RegionsAdultAmino Acid SubstitutionBlack PeopleCell Line, TumorCells, CulturedCohort StudiesFemaleGene Expression RegulationGenetic Association StudiesGlucocorticoidsHispanic or LatinoHumansMacrophagesMaleNorth CarolinaPolymorphism, Single NucleotideProspective StudiesReceptors, GlucocorticoidRecombinant ProteinsRegistriesSignal TransductionWhite PeopleConceptsGene expression profilesGene expressionExpression profilesGlucocorticoid sensitivityT polymorphismWide gene expressionPrimary macrophagesInherent transcriptional activityHigher serum cortisol levelsLow-dose dexamethasoneProspective cohort studyProtein expressionSelf-reported allergiesDominant negative regulatorSerum cortisol levelsReceptor protein expressionSelf-reported diseasesGlucocorticoid receptor geneHuman glucocorticoid receptor geneMinor allele frequencyNon-Hispanic participantsAlternative splicingMRNA stabilityReceptor stabilityTranscriptional activity
2015
Ghrelin Partially Protects Against Cisplatin-Induced Male Murine Gonadal Toxicity in a GHSR-1a-Dependent Manner1
Whirledge SD, Garcia JM, Smith RG, Lamb DJ. Ghrelin Partially Protects Against Cisplatin-Induced Male Murine Gonadal Toxicity in a GHSR-1a-Dependent Manner1. Biology Of Reproduction 2015, 92: 76, 1-11. PMID: 25631345, PMCID: PMC4367966, DOI: 10.1095/biolreprod.114.123570.Peer-Reviewed Original ResearchConceptsTesticular cell deathTesticular damageGonadal toxicityEpididymal weightGrowth hormone secretagogue receptorDose-dependent side effectsCisplatin-induced cachexiaTime of euthanizationHigh cumulative doseBody weight homeostasisCell deathCisplatin-induced testicular damageNovel therapeutic approachesGonadotoxin exposurePermanent azoospermiaGhrelin administrationSubsequent infertilityChemotherapeutic drug cisplatinChemotherapeutic regimensCisplatin administrationGhrelin actionWeight homeostasisCumulative doseIntraperitoneal administrationSecretagogue receptor
2010
Glucocorticoids, stress, and fertility.
Whirledge S, Cidlowski JA. Glucocorticoids, stress, and fertility. Minerva Endocrinologica 2010, 35: 109-25. PMID: 20595939, PMCID: PMC3547681.Peer-Reviewed Original ResearchConceptsLevels of glucocorticoidsGonadal functionNormal brain developmentTestes/ovariesLevels of glucoseLife-long effectsFetal exposureMaternal exposureStress-related behaviorsAdrenal functionExogenous glucocorticoidsAdrenal axisGonadal axisNeuroendocrine functionGlucocorticoid inhibitionAnatomical sitesPrenatal stressElevated glucocorticoidsGlucocorticoidsPituitary glandReproductive functionBrain developmentStressful challengesFat breakdownMultiple tissues
2005
Stem cells: Implications for urology
Lo K, Whirledge S, Lamb D. Stem cells: Implications for urology. Current Urology Reports 2005, 6: 49-54. PMID: 15610697, DOI: 10.1007/s11934-005-0067-5.Peer-Reviewed Original Research