Featured Publications
Characteristics and Outcomes of Sepsis Presenting in Inpatient Pediatric Settings.
Schafer M, Gruhler De Souza H, Paul R, Riggs R, Richardson T, Conlon P, Duffy S, Foster L, Gunderson J, Hall D, Hatcher L, Hess L, Kirkpatrick L, Kunar J, Lockwood J, Lowerre T, McFadden V, Raghavan A, Rizzi J, Stephen R, Stokes S, Workman J, Kandil S. Characteristics and Outcomes of Sepsis Presenting in Inpatient Pediatric Settings. Hospital Pediatrics 2022, 12: 1048-1059. PMID: 36345706, DOI: 10.1542/hpeds.2022-006592.Peer-Reviewed Original ResearchConceptsSepsis-attributable mortalitySepsis casesVasopressor useInpatient casesRetrospective cohort studyIntensive care admissionInpatient pediatric settingLonger lengthSepsis literatureTreatment bundleCare admissionInpatient cohortBundle adherenceClinical characteristicsCohort studySepsis outcomeSepsis recognitionChildren's HospitalIntensive careMortality outcomesLeading causeInpatient settingPediatric settingData registryED cases
2023
Bundled Care to Reduce Sepsis Mortality: The Improving Pediatric Sepsis Outcomes (IPSO) Collaborative.
Paul R, Niedner M, Riggs R, Richardson T, DeSouza H, Auletta J, Balamuth F, Campbell D, Depinet H, Hueschen L, Huskins W, Kandil S, Larsen G, Mack E, Priebe G, Rutman L, Schafer M, Scott H, Silver P, Stalets E, Wathen B, Macias C, Brilli R. Bundled Care to Reduce Sepsis Mortality: The Improving Pediatric Sepsis Outcomes (IPSO) Collaborative. Pediatrics 2023, 152 PMID: 37435672, DOI: 10.1542/peds.2022-059938.Peer-Reviewed Original ResearchConceptsSepsis-attributable mortalityCare bundleSepsis outcomeSepsis patientsEvidence-based care bundleChildren's Hospital AssociationGreater mortality reductionHospital AssociationSepsis care bundlesIC cohortISS cohortSepsis mortalityOrgan dysfunctionSepsis bundleSeptic shockPediatric sepsisChildren's HospitalSpecial cause variationBundle complianceMortality reductionImproved outcomesTimely treatmentPearson χKruskal-Wallis testMortality
2016
Vitamin D Status After Cardiopulmonary Bypass in Children With Congenital Heart Disease
Zahr R, Faustino EV, Carpenter T, Kirshbom P, Hall EK, Fahey JT, Kandil SB. Vitamin D Status After Cardiopulmonary Bypass in Children With Congenital Heart Disease. Journal Of Intensive Care Medicine 2016, 32: 508-513. PMID: 27251108, DOI: 10.1177/0885066616652077.Peer-Reviewed Original ResearchConceptsCongenital heart diseasePg/mLCardiopulmonary bypassVitamin D binding proteinD binding proteinHeart diseaseAlbumin levelsTime pointsVitamin D deficiencyVitamin D statusProspective observational studyMean levelsFree fractionD deficiencyD statusDihydroxyvitamin DObservational studySurgeryBinding proteinBypassDiseaseMeasures analysisChildrenDeficiencyML
2014
A pediatric critical care perspective on vitamin D
Abou-Zahr R, Kandil SB. A pediatric critical care perspective on vitamin D. Pediatric Research 2014, 77: 164-167. PMID: 25314583, DOI: 10.1038/pr.2014.167.Peer-Reviewed Original ResearchConceptsVitamin DCardiac diseaseIntensive care unit stayLow vitamin D levelsCritical care perspectiveMore fluid resuscitationVitamin D levelsVitamin D supplementationVitamin D deficiencyVitamin D statusCongestive heart failureSeverity of illnessPostoperative cardiac patientsPediatric cardiac populationMechanism of actionD supplementationInotrope supportNoncardiac populationUnit stayD deficiencyD statusCritical illnessFluid resuscitationHeart failureClinical outcomes
2013
Retrospective Outcomes of Glucose Control in Critically Ill Children
Kandil SB, Spear D, Thomas NJ, Weinzimer SA, Faustino EV. Retrospective Outcomes of Glucose Control in Critically Ill Children. Journal Of Diabetes Science And Technology 2013, 7: 1220-1228. PMID: 24124949, PMCID: PMC3876366, DOI: 10.1177/193229681300700512.Peer-Reviewed Original ResearchConceptsIll childrenGlucose controlBlood glucoseTreatment groupsBaseline groupVasopressor-free daysVentilator-free daysCritically Ill ChildrenIntensive care unitMean blood glucoseBlood glucose controlICU stayRetrospective cohortPatient characteristicsCare unitRandomized trialsHistorical cohortRetrospective outcomesWorse outcomesGlucose metricsHyperglycemiaSimilar childrenFree daysDlConflicting resultsControl of serum glucose concentration in critical illness
Kandil SB, Miksa M, Faustino EV. Control of serum glucose concentration in critical illness. Current Opinion In Pediatrics 2013, 25: 297-303. PMID: 23657243, DOI: 10.1097/mop.0b013e328360c6a0.Peer-Reviewed Original ResearchConceptsTight glycemic controlIll childrenPostoperative cardiac surgery patientsCardiac surgery patientsInsulin-induced hypoglycemiaRisk of deathSerum glucose concentrationLong-term safetyCritical illnessSurgery patientsGlycemic controlPediatric patientsClinical benefitCardiac patientsAdult studiesLatest evidenceNeurocognitive developmentHypoglycemiaPatientsAdverse effectsDiscrepant resultsGlucose concentrationHyperglycemiaChildrenTrials
2012
Transport Disposition Using the Transport Risk Assessment in Pediatrics (TRAP) Score
Kandil SB, Sanford H, Northrup V, Bigham MT, Giuliano JS. Transport Disposition Using the Transport Risk Assessment in Pediatrics (TRAP) Score. Prehospital Emergency Care 2012, 16: 366-373. PMID: 22443350, PMCID: PMC3360797, DOI: 10.3109/10903127.2012.664246.Peer-Reviewed Original ResearchConceptsPediatric patientsPICU admissionTransport teamPediatric intensive care unit admissionIntensive care unit admissionCare unit admissionTertiary care centerPediatric specialty transport teamInitial assessmentUnit admissionChart reviewChildren's HospitalDirect admissionCare centerObservational studyHigher scoresPatientsPediatric scoresPhysiologic variablesScore's abilityAdmissionLogistic regressionTriage decisionsSpecialized teamTRAP scores