2021
Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation
Tyler PM, Bucklin ML, Zhao M, Maher TJ, Rice AJ, Ji W, Warner N, Pan J, Morotti R, McCarthy P, Griffiths A, van Rossum AMC, Hollink IHIM, Dalm VASH, Catanzaro J, Lakhani SA, Muise AM, Lucas CL. Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation. Nature Immunology 2021, 22: 1118-1126. PMID: 34326534, PMCID: PMC8985851, DOI: 10.1038/s41590-021-00984-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalgranulin ADNA-Binding ProteinsFemaleGene Expression RegulationHereditary Autoinflammatory DiseasesHumansInflammatory Bowel DiseasesInterleukin 1 Receptor Antagonist ProteinLipocalin-2LipopolysaccharidesMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutTh17 CellsTranscription FactorsTranscription, GeneticTriggering Receptor Expressed on Myeloid Cells-1ConceptsInterleukin-1Inflammatory bowel disease (IBD) characteristicsInflammatory immune cellsHuman inflammatory disordersAnti-inflammatory genesTumor necrosis factorHuman autoinflammatory diseasesInnate stimuliHyperinflammatory responseMale patientsNeutrophil chemoattractantDisease characteristicsInflammatory disordersMucosal diseaseImmune cellsInflammation amplifierNecrosis factorUnrelated male patientsAutoinflammatory diseasesMouse modelBroad translational relevanceTranslational relevanceInflammationFunction variantsMouse macrophages
2003
Toll-like receptor signaling in sepsis
Lakhani SA, Bogue CW. Toll-like receptor signaling in sepsis. Current Opinion In Pediatrics 2003, 15: 278-282. PMID: 12806257, DOI: 10.1097/00008480-200306000-00009.Peer-Reviewed Original ResearchMeSH KeywordsHumansLipopolysaccharidesMembrane GlycoproteinsReceptors, Cell SurfaceSepsisSignal TransductionToll-Like Receptor 4Toll-Like ReceptorsConceptsToll-like receptorsBacterial sepsisPediatric intensive care unitIntensive care unitPotential therapeutic approachPotential therapeutic strategySystemic inflammationCare unitMammalian immune systemInflammatory responseTLR signalingTherapeutic approachesTherapeutic strategiesDisease processSepsisImmune systemLPS responseBacterial lipopolysaccharideMajor causeMolecular patternsReceptorsOngoing evaluationMolecular biologyLipopolysaccharideMorbidity