2014
Protective Effect of Methicillin-Susceptible Staphylococcus aureus Carriage against Methicillin-Resistant S. aureus Acquisition in Nursing Homes: A Prospective Cross-Sectional Study
Datta R, Quan V, Kim D, Peterson EM, Reynolds C, Meyers H, Cheung M, Huang SS. Protective Effect of Methicillin-Susceptible Staphylococcus aureus Carriage against Methicillin-Resistant S. aureus Acquisition in Nursing Homes: A Prospective Cross-Sectional Study. Infection Control And Hospital Epidemiology 2014, 35: 1257-1262. PMID: 25203179, DOI: 10.1086/678062.Peer-Reviewed Original ResearchConceptsProspective cross-sectional studyCross-sectional studyS. aureus prevalencePoint prevalenceAdmission prevalenceNursing homesAureus prevalenceInverse associationMethicillin-resistant S. aureus (MRSA) prevalenceS. aureus acquisitionMethicillin-susceptible Staphylococcus aureus (MSSA) carriageDay of admissionStaphylococcus aureus carriageNursing home stayBlood agarMinimal associationMSSA carriageAureus carriageMRSA acquisitionPercentage of residentsNares swabsProtective effectSkin lesionsTotal swabsSheep blood agar
2013
High Nasal Burden of Methicillin-Resistant Staphylococcus aureus Increases Risk of Invasive Disease
Datta R, Shah A, Huang SS, Cui E, Nguyen V, Welbourne SJ, Quan KA, Thrupp L. High Nasal Burden of Methicillin-Resistant Staphylococcus aureus Increases Risk of Invasive Disease. Journal Of Clinical Microbiology 2013, 52: 312-314. PMID: 24153126, PMCID: PMC3911445, DOI: 10.1128/jcm.01606-13.Peer-Reviewed Original Research
2012
What Is Nosocomial? Large Variation in Hospital Choice of Numerators and Denominators Affects Rates of Hospital-Onset Methicillin-Resistant Staphylococcus aureus
Datta R, King M, Kim D, Nguyen C, Elkins K, Gombosev A, Avery TR, Meyers H, Cheung M, Huang SS. What Is Nosocomial? Large Variation in Hospital Choice of Numerators and Denominators Affects Rates of Hospital-Onset Methicillin-Resistant Staphylococcus aureus. Infection Control And Hospital Epidemiology 2012, 33: 1166-1169. PMID: 23041819, DOI: 10.1086/668025.Peer-Reviewed Original Research
2011
Methicillin-Resistant Staphylococcus aureus Infection and Hospitalization in High-Risk Patients in the Year following Detection
Huang SS, Hinrichsen VL, Datta R, Spurchise L, Miroshnik I, Nelson K, Platt R. Methicillin-Resistant Staphylococcus aureus Infection and Hospitalization in High-Risk Patients in the Year following Detection. PLOS ONE 2011, 6: e24340. PMID: 21949707, PMCID: PMC3174953, DOI: 10.1371/journal.pone.0024340.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureus (MRSA) infectionsPost-discharge infectionsStaphylococcus aureus infectionMRSA infectionHealthcare utilizationAureus infectionTertiary care medical centerPrimary bloodstream infectionsRetrospective cohort studyHigh-risk patientsTertiary care patientsHarvard Pilgrim Health CareSubstantial attributable mortalitySingle hospitalizationMRSA carriageMRSA carriersAdult patientsCohort studyHospital dischargeSubsequent readmissionCare patientsAttributable mortalityBloodstream infectionsCommon infectionsMost infectionsColonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control study
Huang SS, Datta R, Rifas-Shiman S, Kleinman K, Placzek H, Lankiewicz JD, Platt R. Colonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control study. Critical Care 2011, 15: r210. PMID: 21914221, PMCID: PMC3334754, DOI: 10.1186/cc10445.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusMethicillin-sensitive Staphylococcus aureusVancomycin-resistant enterococciInitial negative swabCase-control studyVancomycin-sensitive enterococciMRSA acquisitionVRE acquisitionICU admissionRisk factorsNegative swabsStaphylococcus aureusHigh endemic settingMRSA-positive patientsVancomycin-resistant enterococci acquisitionThird-generation cephalosporinsSensitive strainsPredictors of acquisitionBilateral naresMSSA carriageMSSA infectionsSame hospitalizationICU patientsLow albuminMRSA infectionEnvironmental Cleaning Intervention and Risk of Acquiring Multidrug-Resistant Organisms From Prior Room Occupants
Datta R, Platt R, Yokoe DS, Huang SS. Environmental Cleaning Intervention and Risk of Acquiring Multidrug-Resistant Organisms From Prior Room Occupants. JAMA Internal Medicine 2011, 171: 491-494. PMID: 21444840, DOI: 10.1001/archinternmed.2011.64.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusRisk of acquisitionPrior room occupantsVancomycin-resistant enteroccociIntensive care unitCare unitIntervention periodAcquisition of MRSAIntensive care unit roomsRetrospective cohort studyMultidrug-resistant organismsAcademic medical centerEnvironmental cleaning interventionsVRE acquisitionEligible patientsMRSA carriersVRE transmissionCardiac surgeryCohort studyMRSA acquisitionNeurosurgery unitThoracic surgeryMedical CenterVRE carriersGeneral surgery
2010
Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice
Skurnik D, Merighi M, Grout M, Gadjeva M, Maira-Litran T, Ericsson M, Goldmann DA, Huang SS, Datta R, Lee JC, Pier GB. Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice. Journal Of Clinical Investigation 2010, 120: 3220-3233. PMID: 20739753, PMCID: PMC2929724, DOI: 10.1172/jci42748.Peer-Reviewed Original ResearchConceptsS. aureus infectionPoly-N-acetyl glucosamineAureus infectionOpsonic killingCapsular polysaccharideNew prophylactic approachS. aureus bacteremiaCommunity-acquired infectionsStaphylococcus aureus antigenOPK activityAureus bacteremiaProtective immunityComplement depositionEffective immunityProphylactic approachMouse modelSuch antigensVaccine componentsIdiotype interactionsHuman immunityAnimal antiseraGram-positive bacterial pathogensHuman antibodiesInfectionMonoclonal antibodies
2008
Risk of Infection and Death due to Methicillin- Resistant Staphylococcus aureus in Long-Term Carriers
Datta R, Huang SS. Risk of Infection and Death due to Methicillin- Resistant Staphylococcus aureus in Long-Term Carriers. Clinical Infectious Diseases 2008, 47: 176-181. PMID: 18532892, PMCID: PMC2649874, DOI: 10.1086/589241.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBacteremiaBostonCarrier StateCatheterization, Central VenousCohort StudiesFemaleHospitalizationHumansLogistic ModelsMaleMethicillin ResistanceMiddle AgedPneumoniaRetrospective StudiesRisk FactorsSex FactorsSoft Tissue InfectionsStaphylococcal InfectionsStaphylococcus aureusTime FactorsConceptsMethicillin-resistant Staphylococcus aureusLong-term carriersRisk of infectionMRSA infectionSingle-center retrospective cohort studyCentral venous catheter infectionSubsequent MRSA infectionVenous catheter infectionRetrospective cohort studyShort-term morbiditySoft tissue infectionsDuration of carriageStaphylococcus aureusMRSA colonizationCohort studyCatheter infectionCommon infectionsNew hospitalizationHigh riskSubsequent infectionTime of detectionPersistent riskInfectionSignificant riskDeathStrain-Relatedness of Methicillin- Resistant Staphylococcus aureus Isolates Recovered from Patients with Repeated Infection
Huang SS, Diekema DJ, Warren DK, Zuccotti G, Winokur PL, Tendolkar S, Boyken L, Datta R, Jones RM, Ward MA, Aubrey T, Onderdonk AB, Garcia C, Platt R. Strain-Relatedness of Methicillin- Resistant Staphylococcus aureus Isolates Recovered from Patients with Repeated Infection. Clinical Infectious Diseases 2008, 46: 1241-1247. PMID: 18444862, PMCID: PMC2723744, DOI: 10.1086/529381.Peer-Reviewed Original ResearchConceptsMethicillin-Resistant Staphylococcus aureus IsolatesMethicillin-resistant Staphylococcus aureus (MRSA) detectionStaphylococcus aureus isolatesMRSA infectionRepeated infectionsInvasive diseaseLate infectionAureus isolatesInfectionSame strainInitial detectionMost casesStaphylococcus aureus detectionIsolatesPatientsDiseaseWeeks
2006
Risk of Acquiring Antibiotic-Resistant Bacteria From Prior Room Occupants
Huang SS, Datta R, Platt R. Risk of Acquiring Antibiotic-Resistant Bacteria From Prior Room Occupants. JAMA Internal Medicine 2006, 166: 1945-1951. PMID: 17030826, DOI: 10.1001/archinte.166.18.1945.Peer-Reviewed Original ResearchMeSH KeywordsBostonCarrier StateCohort StudiesCross InfectionEnterococcusFemaleGram-Positive Bacterial InfectionsHospitalizationHumansIntensive Care UnitsMaleMethicillin ResistanceMiddle AgedOdds RatioPatients' RoomsRetrospective StudiesRiskStaphylococcal InfectionsStaphylococcus aureusVancomycin ResistanceConceptsMethicillin-resistant Staphylococcus aureusPrior room occupantsVancomycin-resistant enterococciMRSA-positive patientsVRE-positive patientsRetrospective cohort studyIntensive care unitPopulation attributable riskCare of patientsRisk of transmissionRoutes of transmissionOdds of acquisitionMRSA casesVRE casesCohort studyRoutine admissionCare unitWeekly screeningExcess riskAttributable riskRelative oddsPatientsRoom occupantsAntibiotic-resistant bacteriaAdmissionImpact of Routine Intensive Care Unit Surveillance Cultures and Resultant Barrier Precautions on Hospital-Wide Methicillin-Resistant Staphylococcus aureus Bacteremia
Huang SS, Yokoe DS, Hinrichsen VL, Spurchise LS, Datta R, Miroshnik I, Platt R. Impact of Routine Intensive Care Unit Surveillance Cultures and Resultant Barrier Precautions on Hospital-Wide Methicillin-Resistant Staphylococcus aureus Bacteremia. Clinical Infectious Diseases 2006, 43: 971-978. PMID: 16983607, DOI: 10.1086/507636.Peer-Reviewed Original ResearchConceptsIntensive care unitContact isolation precautionsMRSA bacteremiaStaphylococcus aureus bacteremiaInfection control interventionsIsolation precautionsSurveillance culturesBarrier precautionsAureus bacteremiaIncidence densityHealth care-associated methicillin-resistant Staphylococcus aureus (MRSA) infectionsMethicillin-susceptible Staphylococcus aureus bacteremiaMethicillin-resistant Staphylococcus aureus (MRSA) infectionsControl interventionsMaximal sterile barrier precautionsResistant Staphylococcus aureus BacteremiaCentral venous catheter placementAlcohol-based hand rubHospital-wide reductionVenous catheter placementHand hygiene campaignRoutine surveillance culturesStaphylococcus aureus infectionInterrupted time series designBacteremia rates