2023
In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging
Meerwaldt A, Straathof M, Oosterveld W, van Heijningen C, van Leent M, Toner Y, Munitz J, Teunissen A, Daemen C, van der Toorn A, van Vliet G, van Tilborg G, De Feyter H, de Graaf R, Hol E, Mulder W, Dijkhuizen R. In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 778-790. PMID: 36606595, PMCID: PMC10108187, DOI: 10.1177/0271678x221148970.Peer-Reviewed Original ResearchConceptsTransient middle cerebral artery occlusionPositron emission tomographyGlucose metabolismPost-ischemic brain tissueMiddle cerebral artery occlusionFDG positron emission tomographyFluorodeoxyglucose positron emission tomographyMetabolic imagingSignificant glial activationAcute ischemic strokeCerebral artery occlusionCerebral energy metabolismDeuterium metabolic imagingActive glucose metabolismGlial activationRecanalization therapyArtery occlusionIschemic strokeStroke severityCerebral perfusionC57BL/6 micePoor outcomeElevated lactate productionPathophysiological changesBaseline values
1999
Effects of Hypoxia-Ischemia and Inhibition of Nitric Oxide Synthase on Cerebral Energy Metabolism in Newborn Piglets
Groenendaal F, De Graaf R, Van Vliet G, Nicolay K. Effects of Hypoxia-Ischemia and Inhibition of Nitric Oxide Synthase on Cerebral Energy Metabolism in Newborn Piglets. Pediatric Research 1999, 45: 827-833. PMID: 10367773, DOI: 10.1203/00006450-199906000-00008.Peer-Reviewed Original ResearchConceptsNitric oxide synthaseCerebral energy metabolismHypoxia-ischemiaCerebral hypoxia-ischemiaN-acetylaspartate ratiosOxide synthaseBaseline valuesNewborn pigletsInorganic phosphate ratioHypoxia groupCerebral energy statusEnergy metabolismSaline 1 hEffect of inhibitionBilateral occlusionNω-nitroCarotid arteryAcetylaspartate ratioL-arginineOld pigletsPhosphate ratioBaseline periodReperfusionNNLAPiglets