Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression
Licznerski P, Duman RS. Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression. Neuroscience 2012, 251: 33-50. PMID: 23036622, PMCID: PMC3566360, DOI: 10.1016/j.neuroscience.2012.09.057.Peer-Reviewed Original ResearchConceptsAxo-spinous synapsesAlters spine morphologyPathophysiology of depressionTreatment of depressionLimbic brain regionsEffective therapeutic agentExpression of prePlasticity-related proteinsStress-related illnessesBasic research studiesSynaptic machineryBehavioral deficitsDendritic spinesPsychiatric disordersAnimal modelsFunctional alterationsSynaptic plasticityBrain regionsSpine morphologyPrefrontal cortexTherapeutic agentsStress exposureNeuronal communicationBrain imagingSpine architectureBcl-xL Is Necessary for Neurite Outgrowth in Hippocampal Neurons
Park HA, Licznerski P, Alavian KN, Shanabrough M, Jonas EA. Bcl-xL Is Necessary for Neurite Outgrowth in Hippocampal Neurons. Antioxidants & Redox Signaling 2015, 22: 93-108. PMID: 24787232, PMCID: PMC4281845, DOI: 10.1089/ars.2013.5570.Peer-Reviewed Original ResearchConceptsDeath receptor 6Hippocampal neuronsNeurite outgrowthExacerbation of hypoxiaBcl-xLNeuronal outgrowthNeuronal process outgrowthNeuronal injuryNeurodegenerative stimuliVivo ischemiaHypoxic injuryNeuronal survivalBrain injuryImpairs neurite outgrowthHypoxic controlsSynapse numberAxonal pruningNeurite damageB cellsReceptor 6Synaptic plasticityDR6 expressionSynapse formationEarly increaseNeuronsSelect Overexpression of Homer1a in Dorsal Hippocampus Impairs Spatial Working Memory
Celikel T, Marx V, Freudenberg F, Zivkovic A, Resnik E, Hasan MT, Licznerski P, Osten P, Rozov A, Seeburg PH, Schwarz MK. Select Overexpression of Homer1a in Dorsal Hippocampus Impairs Spatial Working Memory. Frontiers In Neuroscience 2007, 1: 97-110. PMID: 18982121, PMCID: PMC2518050, DOI: 10.3389/neuro.01.1.1.007.2007.Peer-Reviewed Original ResearchLong-term potentiationSynaptic plasticityCA3-CA1 long-term potentiationLong Homer isoformsPostsynaptic excitatory neuronsSpatial working memoryOverexpression of Homer1aDorsal hippocampusGlutamate receptorsExcitatory neuronsSynaptic transmissionCortical areasImpairs spatial working memoryHomer isoformsSimilar impairmentHomer1aLong HomersSpatial workingReference memorySpatial memoryHippocampusFunctional competitionImpairmentOverexpressionExpression of Venus