Mink1 regulates spemann organizer cell fate in the xenopus gastrula via Hmga2
Colleluori V, Khokha M. Mink1 regulates spemann organizer cell fate in the xenopus gastrula via Hmga2. Developmental Biology 2022, 495: 42-53. PMID: 36572140, PMCID: PMC10116378, DOI: 10.1016/j.ydbio.2022.11.010.Peer-Reviewed Original ResearchConceptsSpemann organizerCell fateTranscription factorsMolecular mechanismsSerine/threonine kinaseLeft-right patterningProper heart developmentUnbiased proteomic approachArchitectural transcription factorPlausible molecular mechanismCHD candidate genesVertebrate embryosThreonine kinaseProteomic approachXenopus gastrulaCommon birth defectsHeart developmentCandidate genesCanonical WntOrganizer cellsSequencing studiesMINK1Critical effectorΒ-cateninHMGA2Discovering the Function of Congenital Heart Disease Genes
González D, Khokha M. Discovering the Function of Congenital Heart Disease Genes. 2022, 233-244. DOI: 10.1201/9781003050230-19.Peer-Reviewed Original ResearchLarger brood sizesCongenital heart disease genesCommon congenital birth defectHeart disease genesCongenital heart diseaseLeft-right axisCHD genesCell biologistsOrgan situsBrood sizeLeft-right asymmetryDe novo mutationsDisease genesSequencing studiesBirth defectsCongenital birth defectsGenetic diseasesGenesNovo mutationsDisease mechanismsStructural cardiac abnormalitiesNovel de novo mutationHeart diseaseCardiac abnormalitiesCardiac structure