2021
Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers
MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers. Psychopharmacology 2021, 238: 2083-2090. PMID: 33796907, PMCID: PMC8715498, DOI: 10.1007/s00213-021-05833-8.Peer-Reviewed Original ResearchConceptsDose of nicotineNicotine reinforcementHigh doseSubjective effectsHuman laboratory studiesYoung adult smokersNicotine self-administration modelNon-dependent smokersOvernight nicotine abstinenceEffects modelSelf-administration modelSelf-administration procedureNicotine doseAdult smokersMethodsYoung adultsObjectivesThe current studyNicotine abstinenceNicotine addictionHigh dosesLow dosesPlaceboThreshold doseReinforcement thresholdTobacco productsDose
2019
Randomized placebo-controlled trial of galantamine in individuals with cocaine use disorder
DeVito EE, Carroll KM, Babuscio T, Nich C, Sofuoglu M. Randomized placebo-controlled trial of galantamine in individuals with cocaine use disorder. Journal Of Substance Use And Addiction Treatment 2019, 107: 29-37. PMID: 31757262, PMCID: PMC6918721, DOI: 10.1016/j.jsat.2019.08.009.Peer-Reviewed Original ResearchConceptsCocaine use disorderSignificant treatment group differencesUse disordersEfficacy of galantamineTreatment-seeking cocaine usersCurrent cocaine use disordersGroup differencesCocaine use outcomesSample of individualsTreatment group differencesComorbid opioid use disorderMethadone-maintained individualsMemory capacityAbstinent individualsCocaine useCognitive improvementCognitive outcomesCocaine use reductionCognitive functionUse outcomesCocaine usersGalantamine groupIndividualsDisordersInitial promiseDouble‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamine
2018
Minocycline does not affect experimental pain or addiction-related outcomes in opioid maintained patients
Arout CA, Waters AJ, MacLean RR, Compton P, Sofuoglu M. Minocycline does not affect experimental pain or addiction-related outcomes in opioid maintained patients. Psychopharmacology 2018, 236: 2857-2866. PMID: 30564869, PMCID: PMC6581631, DOI: 10.1007/s00213-018-5146-7.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaCold pressor testOpioid use disorderSerum cytokinesPain thresholdUse disordersAddiction-related outcomesProinflammatory serum cytokinesActivation of microgliaSeverity of painEcological momentary assessmentEnd of treatmentHuman laboratory studiesTest sessionsOpioid cravingMinocycline treatmentOpioid toleranceAgonist treatmentPain sensitivityVisit 1Minocycline effectsPressor testExperimental painPreclinical studiesGo/No-Go task
2015
Intravenous Nicotine Self-Administration in Smokers: Dose–Response Function and Sex Differences
Jensen KP, DeVito EE, Valentine G, Gueorguieva R, Sofuoglu M. Intravenous Nicotine Self-Administration in Smokers: Dose–Response Function and Sex Differences. Neuropsychopharmacology 2015, 41: 2034-2040. PMID: 26717881, PMCID: PMC4908640, DOI: 10.1038/npp.2015.373.Peer-Reviewed Original ResearchConceptsBlood pressureHeart rateFemale smokersRandomized double-blind crossover designDouble-blind crossover designSubjective effectsTobacco-dependent subjectsSex differencesDiastolic blood pressureIntravenous Nicotine Self-AdministrationSelf-administration ratesNicotine Self-AdministrationDose-response functionNicotine dosesNicotine doseTobacco dependenceIntravenous nicotineCrossover designSelf-AdministrationReinforcement thresholdSmokersInfusionNicotineForced-choice trialsAversive responsesThe effects of alcohol-containing e-cigarettes on young adult smokers
Valentine GW, Jatlow PI, Coffman M, Nadim H, Gueorguieva R, Sofuoglu M. The effects of alcohol-containing e-cigarettes on young adult smokers. Drug And Alcohol Dependence 2015, 159: 272-276. PMID: 26778759, PMCID: PMC5171208, DOI: 10.1016/j.drugalcdep.2015.12.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultDouble-Blind MethodDrug CombinationsElectronic Nicotine Delivery SystemsEthanolFemaleGlucuronatesHumansMalePsychomotor PerformanceYoung AdultConceptsSubjective drug effectsE-cigarettesDrug effectsAlcohol metabolitesPlasma alcohol levelsUrine ethyl glucuronideLong-term health risksYoung adult smokersAlcohol conditionE-liquidsAcute safetyAdult smokersNicotine intakeAcute changesSafety dataNicotine addictionCrossover designBiochemical measuresAlcohol levelsPsychomotor performanceElectronic cigarettesDexterity testVulnerable populationsEthyl glucuronideMotor performance
2001
Progesterone treatment during the early follicular phase of the menstrual cycle: Effects on smoking behavior in women
Sofuoglu M, Babb D, Hatsukami D. Progesterone treatment during the early follicular phase of the menstrual cycle: Effects on smoking behavior in women. Pharmacology Biochemistry And Behavior 2001, 69: 299-304. PMID: 11420098, DOI: 10.1016/s0091-3057(01)00527-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureCross-Over StudiesDouble-Blind MethodFemaleFollicular PhaseHeart RateHumansProgesteroneSmokingConceptsEarly follicular phaseProgesterone treatmentFollicular phaseSmoking behaviorFemale smokersMenstrual cycleProgesterone levelsDose of progesteroneEffect of progesteroneSelf-administration periodMedication treatmentEndogenous estradiolExperimental sessionsExogenous progesteroneNicotine dependenceProgesteroneSubjective effectsSmokersTreatmentEstradiolSubjective responsesCigarettesSecond sessionSubjectsWomen
2000
Carvedilol affects the physiological and behavioral response to smoked cocaine in humans
Sofuoglu M, Brown S, Babb D, Pentel P, Hatsukami D. Carvedilol affects the physiological and behavioral response to smoked cocaine in humans. Drug And Alcohol Dependence 2000, 60: 69-76. PMID: 10821991, DOI: 10.1016/s0376-8716(00)80009-5.Peer-Reviewed Original ResearchConceptsAcute treatmentPlacebo-controlled outpatient studyPhysiological effectsEffects of carvedilolDiastolic blood pressureCocaine-induced increasesNumber of cocaineCarvedilol treatmentBlood pressureOral carvedilolOutpatient studyNoradrenergic systemAdrenergic blockersCrack cocaine usersHeart rateCarvedilolBehavioral responsesCocaineCocaine usersCocaine deliveryTreatmentSubjective responsesTreatment conditionsResponseHumansEffects of Labetalol Treatment on the Physiological and Subjective Response to Smoked Cocaine
Sofuoglu M, Brown S, Babb D, Pentel P, Hatsukami D. Effects of Labetalol Treatment on the Physiological and Subjective Response to Smoked Cocaine. Pharmacology Biochemistry And Behavior 2000, 65: 255-259. PMID: 10672977, DOI: 10.1016/s0091-3057(99)00201-4.Peer-Reviewed Original ResearchConceptsSystolic blood pressureLabetalol treatmentBlood pressureDose of labetalolEffects of labetalolSubjective responsesCocaine deliveryHeart rate increaseCocaine-induced increasesEffect of treatmentCrossover studyMedication treatmentCardiovascular responsesHeart rateAdrenergic receptorsLabetalolSmoked CocaineBehavioral effectsSubjective effectsCocaineDrug labetalolCocaine usersTreatmentDosesExperimental sessions
1998
Effects of cotinine on cigarette self-administration
Hatsukami D, Lexau B, Nelson D, Pentel P, Sofuoglu M, Goldman A. Effects of cotinine on cigarette self-administration. Psychopharmacology 1998, 138: 184-189. PMID: 9718288, DOI: 10.1007/s002130050661.Peer-Reviewed Original ResearchMeSH KeywordsAdultCotinineDouble-Blind MethodExtinction, PsychologicalFemaleHumansMaleMiddle AgedNicotineSelf AdministrationSmokingSmoking CessationConceptsDoses of cotinineWithdrawal symptomsCigarette withdrawal symptomsEffects of cotinineNicotine serum levelsSelective modulatory effectNicotine withdrawal symptomsNumber of cigarettesEffects of nicotineMetabolite of nicotineSubjective responsesNicotine patchSerum levelsCigarette smokingNicotine intakeModulatory effectsCarbon monoxide levelsCotinineRandomized orderPlaceboBeneficial effectsCigarettesOutcome variablesDosesSymptoms