2024
Glial modulators as novel therapeutics for comorbid pain and opioid use disorder
Schwartz E, De Aquino J, Sofuoglu M. Glial modulators as novel therapeutics for comorbid pain and opioid use disorder. British Journal Of Clinical Pharmacology 2024 PMID: 38752593, DOI: 10.1111/bcp.16094.Peer-Reviewed Original ResearchOpioid use disorderChronic painGlial modulationNovel treatment approachesComorbid painPublic health problemTreatment approachesImproved pain measuresLiterature search of PubMedIncreased opioid prescriptionsSearch of PubMedAddiction-related outcomesSignificant public health problemComorbid disordersOpioid prescriptionsGoogle Scholar databasesPain measuresHealth problemsPain managementClinical studiesTreatment challengesClinical trialsPatient populationPainGlial activation
2023
Pharmacological Interventions for Impulsivity in Addictive Disorders
Schwartz E, Palmisano A, Sofuoglu M. Pharmacological Interventions for Impulsivity in Addictive Disorders. Current Addiction Reports 2023, 10: 149-165. DOI: 10.1007/s40429-023-00486-3.Peer-Reviewed Original ResearchAddictive disordersPharmacological interventionsAddiction-related outcomesRecent FindingsSeveral studiesGlutamatergic medicationsGlutamatergic systemPatient populationPharmacological treatmentTreatment approachesMedicationsDisorder outcomesDisordersFurther studiesOutcomesInterventionImpulsivityAddictive behaviorsFacets of impulsivityMore standardizationTrait impulsivityPositive signalsDopaminergic
2018
Minocycline does not affect experimental pain or addiction-related outcomes in opioid maintained patients
Arout CA, Waters AJ, MacLean RR, Compton P, Sofuoglu M. Minocycline does not affect experimental pain or addiction-related outcomes in opioid maintained patients. Psychopharmacology 2018, 236: 2857-2866. PMID: 30564869, PMCID: PMC6581631, DOI: 10.1007/s00213-018-5146-7.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaCold pressor testOpioid use disorderSerum cytokinesPain thresholdUse disordersAddiction-related outcomesProinflammatory serum cytokinesActivation of microgliaSeverity of painEcological momentary assessmentEnd of treatmentHuman laboratory studiesTest sessionsOpioid cravingMinocycline treatmentOpioid toleranceAgonist treatmentPain sensitivityVisit 1Minocycline effectsPressor testExperimental painPreclinical studiesGo/No-Go task