2010
Evaluation of Vascular Endothelial Growth Factor as a Prognostic Marker for Local Relapse in Early-Stage Breast Cancer Patients Treated With Breast-Conserving Therapy
Moran MS, Yang Q, Goyal S, Harris L, Chung G, Haffty BG. Evaluation of Vascular Endothelial Growth Factor as a Prognostic Marker for Local Relapse in Early-Stage Breast Cancer Patients Treated With Breast-Conserving Therapy. International Journal Of Radiation Oncology • Biology • Physics 2010, 81: 1236-1243. PMID: 21093162, DOI: 10.1016/j.ijrobp.2010.07.031.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnalysis of VarianceBiomarkers, TumorBlack PeopleBreast NeoplasmsDisease-Free SurvivalFemaleFollow-Up StudiesHumansMastectomy, SegmentalMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRadiotherapyTissue Array AnalysisVascular Endothelial Growth Factor AWhite PeopleConceptsEarly-stage breast cancerBreast-conserving therapyLocal relapse-free survivalRelapse-free survivalVascular endothelial growth factorEarly-stage breast cancer patientsLocal relapseBreast cancer patientsBreast cancerEndothelial growth factorVEGF expressionOverall survivalPrognostic valueCancer patientsTissue microarrayEstrogen receptor/progesterone receptor statusDistant metastasis-free survivalNodal relapse-free survivalGrowth factorProgesterone receptor statusInstitutional review board approvalMetastasis-free survivalLong-term outcomesMargin-negative patientsOverexpression of VEGF
2008
Bcl-2 expression predicts local relapse for early-stage breast cancer receiving conserving surgery and radiotherapy
Yang Q, Moran MS, Haffty BG. Bcl-2 expression predicts local relapse for early-stage breast cancer receiving conserving surgery and radiotherapy. Breast Cancer Research And Treatment 2008, 115: 343. PMID: 18516673, DOI: 10.1007/s10549-008-0068-4.Peer-Reviewed Original ResearchConceptsEarly-stage breast cancerBreast conservation treatmentStage breast cancerBcl-2 expressionBreast cancerIpsilateral breast tumor recurrenceCox proportional hazards modelBreast tumor recurrenceIndependent prognostic factorProgesterone receptor statusOptimal treatment optionsBcl-2Proportional hazards modelBcl-2 antibodyApoptosis-related proteinsBreast recurrenceLocal relapseLocal recurrencePrognostic factorsReceptor statusClinical outcomesPrognostic significanceTreatment optionsTumor recurrencePrimary tumor