2011
Using Nodal Ratios to Predict Risk of Regional Recurrences in Patients Treated with Breast Conservation Therapy with 4 or More Positive Lymph Nodes
Castrucci W, Lannin D, Haffty BG, Higgins SA, Moran MS. Using Nodal Ratios to Predict Risk of Regional Recurrences in Patients Treated with Breast Conservation Therapy with 4 or More Positive Lymph Nodes. International Scholarly Research Notices 2011, 2011: 874814. PMID: 22084784, PMCID: PMC3200302, DOI: 10.5402/2011/874814.Peer-Reviewed Original ResearchHigher nodal ratioBreast conservation therapyNodal ratioLymph nodesRegional recurrenceConservation therapyRegional failureN2/N3 patientsPositive axillary lymph nodesPositive lymph nodesAxillary lymph nodesGroup of patientsIntensive systemic therapyN3 statusDistant failureN3 patientsNodal recurrenceSystemic therapyDose escalationEntire cohortRegional nodesBreast cancerInclusion criteriaPrognostic variablesHigh risk
2010
Ductal Carcinoma In Situ With Microinvasion: Prognostic Implications, Long-Term Outcomes, and Role of Axillary Evaluation
Parikh RR, Haffty BG, Lannin D, Moran MS. Ductal Carcinoma In Situ With Microinvasion: Prognostic Implications, Long-Term Outcomes, and Role of Axillary Evaluation. International Journal Of Radiation Oncology • Biology • Physics 2010, 82: 7-13. PMID: 20950955, DOI: 10.1016/j.ijrobp.2010.08.027.Peer-Reviewed Original ResearchConceptsDistant relapse-free survivalLocal-regional relapseClinical-pathologic featuresRelapse-free survivalBreast conservation therapyLong-term outcomesOverall survivalAxillary evaluationAxillary metastasesIndependent predictorsDuctal carcinomaCox proportional hazards analysisPresence of microinvasionSurgical axillary evaluationAdjuvant hormonal therapyProportional hazards analysisHormonal therapyAggressive treatmentDistant failureMargin statusSurgical evaluationConservation therapyPrognostic implicationsMean ageUnivariate analysis
2009
Local Therapy in BRCA1/2 Carriers with Operable Breast Cancer: Comparison of Breast Conservation and Mastectomy.
Pierce L, Phillips K, Griffith K, Buys S, Gaffney D, Moran M, Haffty B, Ben-David M, Garber J, Merajver S, Balmanya J, Meirovitz A, Domchek S. Local Therapy in BRCA1/2 Carriers with Operable Breast Cancer: Comparison of Breast Conservation and Mastectomy. Cancer Research 2009, 69: 959-959. DOI: 10.1158/0008-5472.sabcs-09-959.Peer-Reviewed Original ResearchContralateral breast cancerOperable breast cancerBreast conservationBreast cancerLocal therapyBRCA1/2 mutationsDistant failureClinical characteristicsBRCA1/2 carriersLocal failureBC-specific survivalDeleterious BRCA1/2 mutationsLocal treatment optionsInvasive lobular cancerGermline BRCA1/2 mutationsSignificant predictorsSignificant differencesOnly significant predictorAdjuvant chemotherapyBCT patientsOverall survivalContralateral breastLobular cancerLocal recurrenceRandomized trials