2014
Muscle-specific activation of Ca2+/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice
Lee HY, Gattu AK, Camporez JP, Kanda S, Guigni B, Kahn M, Zhang D, Galbo T, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Choi CS, Yan Z, Williams RS, Shulman GI, Samuel VT. Muscle-specific activation of Ca2+/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. Diabetologia 2014, 57: 1232-1241. PMID: 24718953, PMCID: PMC5634138, DOI: 10.1007/s00125-014-3212-1.Peer-Reviewed Original ResearchConceptsMitochondrial contentDependent protein kinaseDependent protein kinase IVSkeletal muscleInsulin actionMuscle mitochondrial contentInsulin-stimulated glucose uptakeMuscle-specific activationΓ coactivator 1αGlucose uptakePhosphorylation of AktSkeletal muscle insulin actionProtein kinaseOxidative type IMitochondrial biogenesisKinase IVMuscle insulin actionGLUT4 proteinGlucose metabolismInsulin-stimulated whole-body glucose uptakePleiotropic effectsWhole-body glucose uptakeCAMK4Coactivator 1αWhole-body insulin action
2011
Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice*
Jurczak MJ, Lee AH, Jornayvaz FR, Lee HY, Birkenfeld AL, Guigni BA, Kahn M, Samuel VT, Glimcher LH, Shulman GI. Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice*. Journal Of Biological Chemistry 2011, 287: 2558-2567. PMID: 22128176, PMCID: PMC3268415, DOI: 10.1074/jbc.m111.316760.Peer-Reviewed Original ResearchAnimalsDNA-Binding ProteinsEndoplasmic ReticulumEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressEndoribonucleasesEukaryotic Initiation Factor-2Heat-Shock ProteinsInsulin Receptor Substrate ProteinsInsulin ResistanceJNK Mitogen-Activated Protein KinasesLipid MetabolismLiverMiceMice, KnockoutPhosphorylationProtein Serine-Threonine KinasesRegulatory Factor X Transcription FactorsSignal TransductionTranscription FactorsX-Box Binding Protein 1
2009
MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice
Roth RJ, Le AM, Zhang L, Kahn M, Samuel VT, Shulman GI, Bennett AM. MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice. Journal Of Clinical Investigation 2009, 119: 3817-3829. PMID: 19920356, PMCID: PMC2786792, DOI: 10.1172/jci39054.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDietary FatsDNA PrimersDual Specificity Phosphatase 1Energy MetabolismMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutModels, BiologicalMuscle Fibers, Slow-TwitchObesityP38 Mitogen-Activated Protein KinasesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRNA, MessengerTrans-ActivatorsTranscription FactorsUp-RegulationSensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Expression
Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM. Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Expression. Diabetes 2009, 58: 1499-1508. PMID: 19366863, PMCID: PMC2699879, DOI: 10.2337/db08-1571.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsBlood GlucoseBody CompositionCell Culture TechniquesCrosses, GeneticFatty LiverFemaleGene Expression RegulationHepatocytesHomeostasisInsulinInsulin ResistanceIntegrasesKetonesLipidsLiverMiceMice, TransgenicPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRNA, Small InterferingTrans-ActivatorsTranscription FactorsTriglyceridesConceptsPGC-1alpha levelsCre/lox systemExpression of genesKey metabolic enzymesKey metabolic pathwaysPGC-1alpha activityPGC-1alpha expressionPeroxisome proliferator-activated receptor gamma coactivatorReceptor γ coactivatorLipid metabolismProliferator-activated receptor gamma coactivatorComplete genetic ablationTranscriptional coactivatorNutrient deprivationReceptor gamma coactivatorPGC-1alphaFatty acid oxidationOxidative phosphorylationMetabolic enzymesLox systemCoactivatorLipid homeostasisMetabolic pathwaysGenetic ablationGenetic alterations