2019
Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET
Holmes SE, Gallezot JD, Davis MT, DellaGioia N, Matuskey D, Nabulsi N, Krystal JH, Javitch JA, DeLorenzo C, Carson RE, Esterlis I. Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 2254-2264. PMID: 31744389, PMCID: PMC7585925, DOI: 10.1177/0271678x19886316.Peer-Reviewed Original ResearchConceptsEffects of ketamineKetamine infusionGlutamate transmissionMetabotropic glutamate receptor 5Ketamine-induced effectsKetamine-induced changesGlutamate receptor 5Promising treatment targetDrug challenge studiesTwo-tissue compartment modelMGluR5 radioligandBlood pressureMGluR5 availabilityBaseline scanOutcome measuresHealthy subjectsHeart ratePsychiatric disordersReceptor 5Modulatory effectsMGluR5Treatment targetsChallenge studiesArterial input functionChallenge paradigm
2016
Demonstration and validation of a new pressure-based MRI-safe pain tolerance device
Davis MT, Daniel TA, Witte TK, Beyers RJ, Willis JZ, Wang Y, Denney TS, Katz JS, Salibi N, Deshpande G. Demonstration and validation of a new pressure-based MRI-safe pain tolerance device. Journal Of Neuroscience Methods 2016, 271: 160-168. PMID: 27378028, DOI: 10.1016/j.jneumeth.2016.07.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingEquipment DesignFemaleHumansMagnetic Resonance ImagingMalePainPain MeasurementPressureReproducibility of ResultsYoung AdultConceptsFunctional magnetic resonance imagingPain toleranceAnterior cingulate gyrusPressure-related painMagnetic resonance imagingElicit painPain applicationCingulate gyrusPainT MRI scannerMRI environmentResonance imagingAlgometerAvailable algometerBOLD activationBrain activationValid instrumentMRI scannerPresent studyActivationIdentical procedure