2015
Association of Cumulative Dose of Haloperidol With Next-Day Delirium in Older Medical ICU Patients*
Pisani MA, Araujo KL, Murphy TE. Association of Cumulative Dose of Haloperidol With Next-Day Delirium in Older Medical ICU Patients*. Critical Care Medicine 2015, 43: 996-1002. PMID: 25746748, PMCID: PMC4400211, DOI: 10.1097/ccm.0000000000000863.Peer-Reviewed Original ResearchConceptsMedical ICU patientsNext-day deliriumTime-dependent confoundingICU patientsCumulative doseMedical ICUNonintubated patientsOdds ratioConfusion Assessment MethodTreatment of deliriumDose of haloperidolAge 60 yearsEfficacy of haloperidolRoute of administrationAcademic medical centerImportant clinical covariatesICU stayIntubated patientsClinical covariatesObservational studyHigher oddsMedical CenterDeliriumPatientsHaloperidol
2010
Factors associated with persistent delirium after intensive care unit admission in an older medical patient population
Pisani MA, Murphy TE, Araujo KL, Van Ness PH. Factors associated with persistent delirium after intensive care unit admission in an older medical patient population. Journal Of Critical Care 2010, 25: 540.e1-540.e7. PMID: 20413252, PMCID: PMC2939229, DOI: 10.1016/j.jcrc.2010.02.009.Peer-Reviewed Original ResearchConceptsPersistent deliriumMedical intensive care unit populationIntensive care unit admissionIntensive care unit populationMultivariable logistic regression modelCare unit admissionConfusion Assessment MethodPatients 60 yearsProspective cohort studyUse of haloperidolUse of opioidsSeverity of illnessMedical patient populationLogistic regression modelsICU stayUnit admissionICU deliriumCohort studyPatient demographicsMedication dataPatient populationConsecutive admissionsCode statusDeliriumUnit population
2009
Days of Delirium Are Associated with 1-Year Mortality in an Older Intensive Care Unit Population
Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of Delirium Are Associated with 1-Year Mortality in an Older Intensive Care Unit Population. American Journal Of Respiratory And Critical Care Medicine 2009, 180: 1092-1097. PMID: 19745202, PMCID: PMC2784414, DOI: 10.1164/rccm.200904-0537oc.Peer-Reviewed Original ResearchConceptsICU deliriumPatient populationNumber of daysOlder intensive care unit patientsIntensive care unit populationAdverse long-term outcomesIntensive care unit patientsRelevant covariatesUrban acute care hospitalDuration of deliriumPost-ICU admissionConfusion Assessment MethodOlder patient populationProspective cohort studyCare unit patientsSeverity of illnessLong-term outcomesDays of deliriumPsychoactive medication useAcute care hospitalsChart review methodImportant health outcomesICU admissionCohort studyICU populationBenzodiazepine and opioid use and the duration of intensive care unit delirium in an older population*
Pisani MA, Murphy TE, Araujo KL, Slattum P, Van Ness PH, Inouye SK. Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population*. Critical Care Medicine 2009, 37: 177-183. PMID: 19050611, PMCID: PMC2700732, DOI: 10.1097/ccm.0b013e318192fcf9.Peer-Reviewed Original ResearchConceptsModifiable risk factorsICU deliriumDelirium durationOpioid useRisk factorsFirst episodeMedical intensive care unit patientsIntensive care unit deliriumMedical intensive care unitIntensive care unit patientsUrban university teaching hospitalConfusion Assessment MethodProspective cohort studyCare unit patientsSeverity of illnessIntensive care unitUniversity Teaching HospitalMain outcome measuresUse of benzodiazepinesChart review methodMultivariable regression modelsImpact of benzodiazepinesCohort studyMedian durationUnit patients
2007
Characteristics Associated With Delirium in Older Patients in a Medical Intensive Care Unit
Pisani MA, Murphy TE, Van Ness PH, Araujo KL, Inouye SK. Characteristics Associated With Delirium in Older Patients in a Medical Intensive Care Unit. JAMA Internal Medicine 2007, 167: 1629-1634. PMID: 17698685, DOI: 10.1001/archinte.167.15.1629.Peer-Reviewed Original ResearchConceptsAdmission risk factorsMedical record reviewIntensive care unitICU admissionRisk factorsOlder patientsRecord reviewCare unitMedical intensive care unitUrban university teaching hospitalOlder ICU patientsReceipt of benzodiazepinesConfusion Assessment MethodPatients 60 yearsProspective cohort studyLower arterial pHUniversity Teaching HospitalMain outcome measuresMultivariate logistic regressionDelirium durationICU deliriumCohort studyCreatinine levelsICU patientsArterial pH
2006
A research algorithm to improve detection of delirium in the intensive care unit
Pisani MA, Araujo K, Van Ness PH, Zhang Y, Ely E, Inouye SK. A research algorithm to improve detection of delirium in the intensive care unit. Critical Care 2006, 10: r121. PMID: 16919169, PMCID: PMC1750978, DOI: 10.1186/cc5027.Peer-Reviewed Original ResearchConceptsIntensive care unitDetection of deliriumCAM-ICUChart review methodCohort studyCare unitClinical careMedical intensive care unitDelirium instrumentCAM-ICU ratingsChart-based reviewIll ICU patientsPrevalence of deliriumConfusion Assessment MethodProspective cohort studyResearch settingsDelirium statusChart reviewICU patientsDeliriumDelirium researchPatientsChart-based methodPatient safetyDiagnostic accuracy
2005
Detection of Delirium in the Intensive Care Unit: Comparison of Confusion Assessment Method for the Intensive Care Unit with Confusion Assessment Method Ratings
McNicoll L, Pisani MA, Ely EW, Gifford D, Inouye SK. Detection of Delirium in the Intensive Care Unit: Comparison of Confusion Assessment Method for the Intensive Care Unit with Confusion Assessment Method Ratings. Journal Of The American Geriatrics Society 2005, 53: 495-500. PMID: 15743296, DOI: 10.1111/j.1532-5415.2005.53171.x.Peer-Reviewed Original ResearchConceptsConfusion Assessment MethodIntensive care unitCAM-ICUICU patientsCare unitMini-Mental State ExaminationCAM-ICU methodFalse-negative ratingsOlder ICU patientsRate of deliriumDetection of deliriumUniversity Teaching HospitalCAM methodsDetailed cognitive testingLevel of consciousnessMedical ICUTeaching hospitalInterrater reliability testingState ExaminationPatientsDeliriumCAM criteriaMore deficitsCognitive testingICU
2003
Delirium in the Intensive Care Unit: Occurrence and Clinical Course in Older Patients
McNicoll L, Pisani MA, Zhang Y, Ely EW, Siegel MD, Inouye SK. Delirium in the Intensive Care Unit: Occurrence and Clinical Course in Older Patients. Journal Of The American Geriatrics Society 2003, 51: 591-598. PMID: 12752832, DOI: 10.1034/j.1600-0579.2003.00201.x.Peer-Reviewed Original ResearchConceptsConfusion Assessment MethodOccurrence of deliriumPost-ICU periodICU stayMedical intensive care unit patientsIntensive care unit patientsOlder ICU patientsDevelopment of deliriumHalf of patientsProspective cohort studyCare unit patientsMedical chart reviewNormal mental statusBaseline functional statusSeverity of illnessIntensive care unitUniversity Teaching HospitalSurrogate interviewsHospital stayBaseline characteristicsChart reviewCohort studyFrequent complicationMedical ICUOlder patients