2020
Immunology of the Placenta
Tong M, Abrahams VM. Immunology of the Placenta. Obstetrics And Gynecology Clinics Of North America 2020, 47: 49-63. PMID: 32008671, DOI: 10.1016/j.ogc.2019.10.006.ChaptersConceptsMaternal immune regulationMajor immune cellsMaternal-fetal interfaceInnate immune propertiesObstetric complicationsPregnancy complicationsPreterm birthPregnancy lossImmune cellsImmune regulationImmune propertiesHuman placentaPlacentaComplicationsPreeclampsiaPregnancyInfectionKey mechanismImmunology
2017
Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia
Tong M, Johansson C, Xiao F, Stone PR, James JL, Chen Q, Cree LM, Chamley LW. Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia. Scientific Reports 2017, 7: 16556. PMID: 29185455, PMCID: PMC5707355, DOI: 10.1038/s41598-017-16448-5.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaAntiphospholipid antibodiesTLR-9Placental vesiclesEndothelial cellsFirst trimester human placental explantsMaternal endothelial cell dysfunctionToll-like receptor 9Danger-associated molecular patternsHuman placental explantsPathogenesis of preeclampsiaEndothelial cell dysfunctionEndothelial cell activationPlacental extracellular vesiclesLevels of mtDNAPlacental factorsPlacental explantsReceptor 9Cell dysfunctionNano-vesiclesPreeclampsiaPharmaceutical interventionsCell activationAmount of mtDNAMolecular patternsAggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia
Tong M, Cheng SB, Chen Q, DeSousa J, Stone PR, James JL, Chamley LW, Sharma S. Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia. Scientific Reports 2017, 7: 6694. PMID: 28751735, PMCID: PMC5532246, DOI: 10.1038/s41598-017-07017-x.Peer-Reviewed Original ResearchConceptsPreeclamptic placentasMaternal circulationNormotensive placentasPreeclampsia-like symptomsProduction of transthyretinPathogenesis of preeclampsiaNano-vesiclesPlacental extracellular vesiclesSerum levelsPreeclamptic seraMaternal organsPreeclampsiaPlacentaTotal transthyretinWestern blottingQRT-PCRExtracellular vesiclesSignificant proportionTransthyretin
2016
The reduction in circulating levels of melatonin may be associated with the development of preeclampsia
Zeng K, Gao Y, Wan J, Tong M, Lee A, Zhao M, Chen Q. The reduction in circulating levels of melatonin may be associated with the development of preeclampsia. Journal Of Human Hypertension 2016, 30: 666-671. PMID: 27251079, DOI: 10.1038/jhh.2016.37.Peer-Reviewed Original ResearchConceptsIncidence of preeclampsiaLevels of melatoninDevelopment of preeclampsiaSerum levelsPreeclamptic placentasMelatonin receptorsLate-onset preeclampsiaHealthy pregnant womenPregnancy-specific disorderPathogenesis of preeclampsiaHealthy pregnancyPlacental dysfunctionPregnant womenSuccessful pregnancyPreeclampsiaMelatonin levelsPregnancyIncidenceMelatoninOxidative stressWomenTime onsetPlacentaReceptorsAssociation
2015
Serum uric acid may not be involved in the development of preeclampsia
Chen Q, Lau S, Tong M, Wei J, Shen F, Zhao J, Zhao M. Serum uric acid may not be involved in the development of preeclampsia. Journal Of Human Hypertension 2015, 30: 136-140. PMID: 25994995, DOI: 10.1038/jhh.2015.47.Peer-Reviewed Original ResearchConceptsDevelopment of preeclampsiaSerum levelsSecond trimesterUric acidSeverity of preeclampsiaTime of presentationHigher serum levelsSerum uric acidTime of onsetNormotensive pregnanciesThird trimesterClinical symptomsPregnant womenPreeclampsiaPrediction biomarkersEarly changesRetrospective sampleProspective sampleTrimesterWomenPresentationLess evidenceMeaningful associations