2006
Systematic review: the lower gastrointestinal adverse effects of non‐steroidal anti‐inflammatory drugs
LAINE L, SMITH R, MIN K, CHEN C, DUBOIS RW. Systematic review: the lower gastrointestinal adverse effects of non‐steroidal anti‐inflammatory drugs. Alimentary Pharmacology & Therapeutics 2006, 24: 751-767. PMID: 16918879, DOI: 10.1111/j.1365-2036.2006.03043.x.Peer-Reviewed Original ResearchConceptsNon-steroidal anti-inflammatory drugsLower gastrointestinal adverse effectsLower gastrointestinal injuryGastrointestinal adverse effectsAnti-inflammatory drugsGastrointestinal injuryGastrointestinal effectsClinical eventsAdverse effectsNon-selective non-steroidal anti-inflammatory drugsUpper gastrointestinal effectsHigh-quality trialsLower gastrointestinal tractEndoscopic studyGastrointestinal integrityGastrointestinal tractComputerized databaseCoxibsDisease StudyInjuryLower ratesTrialsDrugsCohortLess effect
1995
Interaction of NSAIDs and Helicobacter pylori on gastrointestinal injury and prostaglandin production: a controlled double‐blind trial
LAINE L, COMINELLI F, SLOANE R, CASINI‐RAGGI V, MARIN‐SORENSEN M, WEINSTEIN WM. Interaction of NSAIDs and Helicobacter pylori on gastrointestinal injury and prostaglandin production: a controlled double‐blind trial. Alimentary Pharmacology & Therapeutics 1995, 9: 127-135. PMID: 7605852, DOI: 10.1111/j.1365-2036.1995.tb00361.x.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsH. pylori infectionNSAID ingestionProstaglandin E2 productionHistological injuryWeek 1H. pyloriGastroduodenal injuryPylori infectionNegative subjectsE2 productionWeek 4Prostaglandin productionH. pylori-associated gastritisDouble-blind trialNormal baseline endoscopyAnti-inflammatory drugsBaseline endoscopyChemical gastritisGastroduodenal damagePlacebo b.Gastrointestinal injuryNSAID useGastric histologyNSAID group