2015
Mutations in DCHS1 cause mitral valve prolapse
Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A, Levine RA, Milan DJ, Norris RA, Slaugenhaupt SA. Mutations in DCHS1 cause mitral valve prolapse. Nature 2015, 525: 109-113. PMID: 26258302, PMCID: PMC4720389, DOI: 10.1038/nature14670.Peer-Reviewed Original Research
2003
A Locus for Autosomal Dominant Mitral Valve Prolapse on Chromosome 11p15.4
Freed LA, Acierno JS, Dai D, Leyne M, Marshall JE, Nesta F, Levine RA, Slaugenhaupt SA. A Locus for Autosomal Dominant Mitral Valve Prolapse on Chromosome 11p15.4. American Journal Of Human Genetics 2003, 72: 1551-1559. PMID: 12707861, PMCID: PMC1180315, DOI: 10.1086/375452.Peer-Reviewed Original Research
2002
Mitral valve prolapse in the general population the benign nature of echocardiographic features in the Framingham Heart Study
Freed LA, Benjamin EJ, Levy D, Larson MG, Evans JC, Fuller DL, Lehman B, Levine RA. Mitral valve prolapse in the general population the benign nature of echocardiographic features in the Framingham Heart Study. Journal Of The American College Of Cardiology 2002, 40: 1298-1304. PMID: 12383578, DOI: 10.1016/s0735-1097(02)02161-7.Peer-Reviewed Original ResearchConceptsMitral valve prolapseClassic mitral valve prolapseFramingham Heart StudyMitral regurgitationHeart StudyEchocardiographic featuresValve prolapsePossible mitral valve prolapseTwo-dimensional echocardiographic criteriaReferral-based seriesSignificant mitral regurgitationGender-matched subjectsMR jet areaMR degreeEchocardiographic abnormalitiesEchocardiographic characteristicsAtrial enlargementEchocardiographic criteriaLA volumeVentricular abnormalitiesVentricular sizeClinical complicationsReferral seriesBenign profileGeneral populationMitral valve prolapse and atrial septal aneurysm: an evaluation in the framingham heart study
Freed L, Levy D, Levine R, Evans J, Larson M, Fuller D, Lehman B, Benjamin E. Mitral valve prolapse and atrial septal aneurysm: an evaluation in the framingham heart study. The American Journal Of Cardiology 2002, 89: 1326-1329. PMID: 12031742, DOI: 10.1016/s0002-9149(02)02340-8.Peer-Reviewed Original Research
1999
Prevalence and Clinical Outcome of Mitral-Valve Prolapse
Freed L, Levy D, Levine R, Larson M, Evans J, Fuller D, Lehman B, Benjamin E. Prevalence and Clinical Outcome of Mitral-Valve Prolapse. New England Journal Of Medicine 1999, 341: 1-7. PMID: 10387935, DOI: 10.1056/nejm199907013410101.Peer-Reviewed Original ResearchConceptsMitral valve prolapseTwo-dimensional echocardiographic criteriaClassic mitral valve prolapseStudy of patientsFramingham Heart StudyChest painFrequent complicationEchocardiographic criteriaElectrocardiographic abnormalitiesHeart failureUnadjusted prevalenceAdverse sequelaeClinical outcomesFifth examinationAtrial fibrillationCerebrovascular diseaseMitral regurgitationMitral leafletSex distributionGeneral populationHeart StudyProlapseOffspring CohortSuperior displacementPrevalencePrevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study)
Singh J, Evans J, Levy D, Larson M, Freed L, Fuller D, Lehman B, Benjamin E. Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study). The American Journal Of Cardiology 1999, 83: 897-902. PMID: 10190406, DOI: 10.1016/s0002-9149(98)01064-9.Peer-Reviewed Original ResearchConceptsBody mass indexColor Doppler echocardiographyClinical determinantsAortic regurgitationDoppler echocardiographyMass indexValvular regurgitationMultiple logistic regression analysisPopulation-based cohortPopulation-based estimatesLogistic regression analysisAnorectic drugsClinical variablesFramingham StudyHealthy menMale genderMild severityFemale genderMitralTricuspidGeneral populationRoutine examinationRegurgitationPrevalenceWomen
1997
Gender Differences in Presentation, Management, and Cardiac Event-Free Survival in Patients With Syncope
Freed L, Eagle K, Mahjoub Z, Gold M, Smith A, Terrell L, O’Gara P, Paul S. Gender Differences in Presentation, Management, and Cardiac Event-Free Survival in Patients With Syncope. The American Journal Of Cardiology 1997, 80: 1183-1187. PMID: 9359547, DOI: 10.1016/s0002-9149(97)00637-1.Peer-Reviewed Original ResearchConceptsCardiac event-free survivalAbnormal signal-averaged electrocardiogramEvent-free survivalSignal-averaged electrocardiogramCardiac event-free survival rateEvent-free survival rateGender-based differencesLeft ventricular dysfunctionPrognosis of patientsVentricular ejection fractionSignal-averaged electrocardiographyMassachusetts General HospitalCardiac causesVentricular dysfunctionCardiac eventsElectrophysiologic testingCardiac syncopeConsecutive patientsCoronary angiographyEjection fractionHospital admissionClinical presentationVentricular arrhythmiasHolter monitoringGeneral HospitalRelation of Ultra-Low Frequency Heart Rate Variability to the Clinical Course of Chronic Aortic Regurgitation
Freed L, Stein K, Borer J, Hochreiter C, Supino P, Devereux R, Roman M, Kligfield P. Relation of Ultra-Low Frequency Heart Rate Variability to the Clinical Course of Chronic Aortic Regurgitation. The American Journal Of Cardiology 1997, 79: 1482-1487. PMID: 9185637, DOI: 10.1016/s0002-9149(97)00175-6.Peer-Reviewed Original ResearchConceptsFrequency heart rate variabilityHeart rate variabilityChronic aortic regurgitationEnd-point eventsAortic regurgitationSymptomatic patientsNew York Heart Association functional class IChronic severe aortic regurgitationLeft ventricular ejection fractionLV end-diastolic dimensionLV end-systolic dimensionMeasures of HRVRate variabilitySevere aortic regurgitationAortic valve replacementEnd-diastolic dimensionCongestive heart failureEnd-systolic dimensionFunctional class IVentricular ejection fractionSudden cardiac deathRegurgitant valvular diseaseClinical outcome eventsMean RR intervalAverage annual risk
1996
Rhythm annotation and interobserver reproducibility of measures of heart rate variability
Kroll D, Freed L, Stein K, Borer J, Kligfield P. Rhythm annotation and interobserver reproducibility of measures of heart rate variability. The American Journal Of Cardiology 1996, 78: 1055-1057. PMID: 8916491, DOI: 10.1016/s0002-9149(96)00537-1.Peer-Reviewed Original Research
1994
Reproducibilfty of power spectral measures of heart rate variability obtained from short-term sampling periods
Freed L, Stein K, Gordon M, Urban M, Kligfield P. Reproducibilfty of power spectral measures of heart rate variability obtained from short-term sampling periods. The American Journal Of Cardiology 1994, 74: 972-973. PMID: 7977138, DOI: 10.1016/0002-9149(94)90604-1.Peer-Reviewed Original Research