1999
Prevalence and Clinical Outcome of Mitral-Valve Prolapse
Freed L, Levy D, Levine R, Larson M, Evans J, Fuller D, Lehman B, Benjamin E. Prevalence and Clinical Outcome of Mitral-Valve Prolapse. New England Journal Of Medicine 1999, 341: 1-7. PMID: 10387935, DOI: 10.1056/nejm199907013410101.Peer-Reviewed Original ResearchConceptsMitral valve prolapseTwo-dimensional echocardiographic criteriaClassic mitral valve prolapseStudy of patientsFramingham Heart StudyChest painFrequent complicationEchocardiographic criteriaElectrocardiographic abnormalitiesHeart failureUnadjusted prevalenceAdverse sequelaeClinical outcomesFifth examinationAtrial fibrillationCerebrovascular diseaseMitral regurgitationMitral leafletSex distributionGeneral populationHeart StudyProlapseOffspring CohortSuperior displacementPrevalence
1997
Gender Differences in Presentation, Management, and Cardiac Event-Free Survival in Patients With Syncope
Freed L, Eagle K, Mahjoub Z, Gold M, Smith A, Terrell L, O’Gara P, Paul S. Gender Differences in Presentation, Management, and Cardiac Event-Free Survival in Patients With Syncope. The American Journal Of Cardiology 1997, 80: 1183-1187. PMID: 9359547, DOI: 10.1016/s0002-9149(97)00637-1.Peer-Reviewed Original ResearchConceptsCardiac event-free survivalAbnormal signal-averaged electrocardiogramEvent-free survivalSignal-averaged electrocardiogramCardiac event-free survival rateEvent-free survival rateGender-based differencesLeft ventricular dysfunctionPrognosis of patientsVentricular ejection fractionSignal-averaged electrocardiographyMassachusetts General HospitalCardiac causesVentricular dysfunctionCardiac eventsElectrophysiologic testingCardiac syncopeConsecutive patientsCoronary angiographyEjection fractionHospital admissionClinical presentationVentricular arrhythmiasHolter monitoringGeneral HospitalRelation of Ultra-Low Frequency Heart Rate Variability to the Clinical Course of Chronic Aortic Regurgitation
Freed L, Stein K, Borer J, Hochreiter C, Supino P, Devereux R, Roman M, Kligfield P. Relation of Ultra-Low Frequency Heart Rate Variability to the Clinical Course of Chronic Aortic Regurgitation. The American Journal Of Cardiology 1997, 79: 1482-1487. PMID: 9185637, DOI: 10.1016/s0002-9149(97)00175-6.Peer-Reviewed Original ResearchConceptsFrequency heart rate variabilityHeart rate variabilityChronic aortic regurgitationEnd-point eventsAortic regurgitationSymptomatic patientsNew York Heart Association functional class IChronic severe aortic regurgitationLeft ventricular ejection fractionLV end-diastolic dimensionLV end-systolic dimensionMeasures of HRVRate variabilitySevere aortic regurgitationAortic valve replacementEnd-diastolic dimensionCongestive heart failureEnd-systolic dimensionFunctional class IVentricular ejection fractionSudden cardiac deathRegurgitant valvular diseaseClinical outcome eventsMean RR intervalAverage annual risk