1997
Relation of Ultra-Low Frequency Heart Rate Variability to the Clinical Course of Chronic Aortic Regurgitation
Freed L, Stein K, Borer J, Hochreiter C, Supino P, Devereux R, Roman M, Kligfield P. Relation of Ultra-Low Frequency Heart Rate Variability to the Clinical Course of Chronic Aortic Regurgitation. The American Journal Of Cardiology 1997, 79: 1482-1487. PMID: 9185637, DOI: 10.1016/s0002-9149(97)00175-6.Peer-Reviewed Original ResearchConceptsFrequency heart rate variabilityHeart rate variabilityChronic aortic regurgitationEnd-point eventsAortic regurgitationSymptomatic patientsNew York Heart Association functional class IChronic severe aortic regurgitationLeft ventricular ejection fractionLV end-diastolic dimensionLV end-systolic dimensionMeasures of HRVRate variabilitySevere aortic regurgitationAortic valve replacementEnd-diastolic dimensionCongestive heart failureEnd-systolic dimensionFunctional class IVentricular ejection fractionSudden cardiac deathRegurgitant valvular diseaseClinical outcome eventsMean RR intervalAverage annual risk
1995
975-81 Prognostic Value of Ultra-Low Frequency Heart Rate Variability in Chronic Aortic Regurgitation
Freed L, Stein K, Borer J, Hochreiter C, Supino P, Devereux R, Kligfield P. 975-81 Prognostic Value of Ultra-Low Frequency Heart Rate Variability in Chronic Aortic Regurgitation. Journal Of The American College Of Cardiology 1995, 25: 254a. DOI: 10.1016/0735-1097(95)92513-5.Peer-Reviewed Original ResearchFrequency heart rate variabilityHeart rate variabilityAortic regurgitationCardiac deathRate variabilitySymptomatic patientsPrognostic valueChronic severe aortic regurgitationNYHA functional class IEvident coronary diseasePure aortic regurgitationChronic aortic regurgitationSevere aortic regurgitationAortic valve replacementEvent-free survivalFunctional class IRisk of progressionLog-rank testRegurgitant valvular diseaseLeft ventricular ejectionMean RR intervalAverage annual riskValve replacementCoronary diseaseEndpoint events