2021
Visual trajectories and risk of physical and cognitive impairment among older Chinese adults
Cao G, Wang K, Han L, Zhang Q, Yao S, Chen Z, Huang Z, Luo Y, Hu Y, Xu B. Visual trajectories and risk of physical and cognitive impairment among older Chinese adults. Journal Of The American Geriatrics Society 2021, 69: 2877-2887. PMID: 34111310, DOI: 10.1111/jgs.17311.Peer-Reviewed Original ResearchConceptsOlder Chinese adultsIADL disabilityCognitive impairmentChinese adultsADL disabilityFunctional impairmentCognitive functionMini-Mental State Examination scoreProgressive declineChinese Longitudinal Healthy Longevity SurveyState Examination scoreModerate declineGroup-based trajectory modelsKatz scaleLawton scalePotential confoundersLongevity SurveyImpairmentDecline trajectoriesChinese versionDisabilityLongitudinal studyAdultsRiskExamination scores
2020
Factors Associated With Insidious and Noninsidious Disability
Gill TM, Murphy TE, Gahbauer EA, Leo-Summers L, Han L. Factors Associated With Insidious and Noninsidious Disability. The Journals Of Gerontology Series A 2020, 75: 2125-2129. PMID: 31907523, PMCID: PMC7566549, DOI: 10.1093/gerona/glaa002.Peer-Reviewed Original ResearchConceptsRisk factorsIllness/injuryInsidious disabilityLower extremity muscle weaknessNon-Hispanic white raceExtremity muscle weaknessCommunity-living personsEmergency department visitsPoor manual dexterityCox analysisDepartment visitsMultivariable analysisDisability outcomesMuscle weaknessWhite raceDaily livingCognitive impairmentBivariate analysisType of disabilityManual dexterityDisabilityInjuryOutcomesModest differencesDifferent mechanisms
2018
Insomnia in Community‐Living Persons with Advanced Age
Miner B, Gill TM, Yaggi HK, Redeker NS, Van Ness PH, Han L, Fragoso CAV. Insomnia in Community‐Living Persons with Advanced Age. Journal Of The American Geriatrics Society 2018, 66: 1592-1597. PMID: 29785710, PMCID: PMC6167156, DOI: 10.1111/jgs.15414.Peer-Reviewed Original ResearchConceptsSelf-reported sleep-disordered breathingRestless legs syndromeInsomnia Severity IndexDepressive symptomsBaseline characteristicsOlder adultsCognitive impairmentAverage baseline characteristicsEpidemiology of insomniaChronic lung diseaseSleep-disordered breathingMultivariable regression modelsHigh medical burdenCurrent smokersLegs syndromeLung diseaseClinical correlatesDaytime sleepinessSleep disturbancesAdvanced ageMedical burdenMild severityCardiovascular diseaseDiagnostic confirmationHigh prevalencePrognostic Effect of Changes in Physical Function Over Prior Year on Subsequent Mortality and Long‐Term Nursing Home Admission
Gill TM, Han L, Gahbauer EA, Leo‐Summers L, Allore HG. Prognostic Effect of Changes in Physical Function Over Prior Year on Subsequent Mortality and Long‐Term Nursing Home Admission. Journal Of The American Geriatrics Society 2018, 66: 1587-1591. PMID: 29719039, PMCID: PMC6133765, DOI: 10.1111/jgs.15399.Peer-Reviewed Original ResearchConceptsLong-term nursing home admissionNursing home admissionHome admissionPhysical functionDisability scoresPrognostic effectDaily livingPrior yearCommunity-living personsRisk of deathUseful prognostic informationProspective longitudinal studyAdverse outcomesPrognostic informationMultivariable modelInstrumental activitiesSubsequent mortalityAdmissionBivariate predictorsSubsequent outcomesMonthsDifferent intervalsComprehensive assessmentDeathLongitudinal study
2017
Joint Trajectories of Cognition and Frailty and Associated Burden of Patient-Reported Outcomes
Liu Z, Han L, Gahbauer EA, Allore HG, Gill TM. Joint Trajectories of Cognition and Frailty and Associated Burden of Patient-Reported Outcomes. Journal Of The American Medical Directors Association 2017, 19: 304-309.e2. PMID: 29146224, PMCID: PMC6054444, DOI: 10.1016/j.jamda.2017.10.010.Peer-Reviewed Original ResearchConceptsPatient-reported outcomesNursing home admissionException of hospitalizationMini-Mental State ExaminationFrailty groupHome admissionCumulative burdenSlower cognitive declineCognitive frailtyCognitive declineProgressive frailtyCommunity-living older personsGreater burdenJoint trajectory groupsHigh cumulative burdenCommunity-living personsIncidence density rateLow physical activitySlow walking speedTrajectory groupsEquation Poisson modelsRapid cognitive declineDistinct joint trajectoriesFried phenotypeMuscle weakness
2016
Dyspnea in Community‐Dwelling Older Persons: A Multifactorial Geriatric Health Condition
Miner B, Tinetti ME, Van Ness PH, Han L, Leo‐Summers L, Newman AB, Lee PJ, Fragoso C. Dyspnea in Community‐Dwelling Older Persons: A Multifactorial Geriatric Health Condition. Journal Of The American Geriatrics Society 2016, 64: 2042-2050. PMID: 27549914, PMCID: PMC5073004, DOI: 10.1111/jgs.14290.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnkle Brachial IndexBody Mass IndexCausalityComorbidityCross-Sectional StudiesDyspneaEchocardiographyElectric ImpedanceFemaleGeriatric AssessmentHumansIndependent LivingMaleMental CompetencyRespiratory Function TestsRisk FactorsSeverity of Illness IndexStatistics as TopicUnited StatesConceptsBody mass indexSevere dyspneaOlder personsChair standCommunity-dwelling older personsMultivariable logistic regression modelHealth conditionsWhole body muscle massMini-Mental State ExaminationAnkle-brachial indexEpidemiologic Studies Depression ScaleRespiratory muscle weaknessMaximal inspiratory pressureVentricular ejection fractionCardiovascular Health StudyCommunity-dwelling personsDiastolic cardiac dysfunctionLogistic regression modelsGrip weaknessSerum hemoglobinBlood pressureDyspnea severityEjection fractionMedication useCardiac dysfunction
2015
The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people
Gill TM, Gahbauer EA, Han L, Allore HG. The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people. The BMJ 2015, 350: h2361. PMID: 25995357, PMCID: PMC4443433, DOI: 10.1136/bmj.h2361.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedCohort StudiesConnecticutDementiaDisability EvaluationDisabled PersonsDisease ProgressionFemaleFrail ElderlyGeriatric AssessmentHospitalizationHumansMaleMultiple Organ FailureNeoplasmsPrognosisProspective StudiesSeverity of Illness IndexTerminal CareUnited StatesConceptsCourse of disabilityProspective cohort studyHospital admissionTrajectories of disabilitySeverity of disabilityCatastrophic disabilitySevere disabilityCohort studyAcute hospital admissionPalliative care approachMultiple hospital admissionsAdvance care planningPersonal care needsEnd of lifeDisability scoresOlder patientsPotential confoundersOccurrence of admissionMultivariable modelCare planningMAIN OUTCOMECare approachDaily livingCare needsAdmission
2014
Epidemiology of Restricting Fatigue in Older Adults: The Precipitating Events Project
de Rekeneire N, Leo‐Summers L, Han L, Gill TM. Epidemiology of Restricting Fatigue in Older Adults: The Precipitating Events Project. Journal Of The American Geriatrics Society 2014, 62: 476-481. PMID: 24512073, PMCID: PMC4103720, DOI: 10.1111/jgs.12685.Peer-Reviewed Original ResearchConceptsCommunity-living older adultsPhysical frailtyOlder adultsCommunity-living older menEpidemiologic Studies Depression ScaleProspective cohort studySlow gait speedOverall incidence ratePrecipitating Events ProjectCohort studyCumulative incidenceMedian durationGait speedIncidence rateDepression ScaleUsual activitiesOlder menFrailtyDepressionMonthsWomenConsecutive monthsAdultsHigh rateRespective counterparts
2013
Dynamics of functional aging based on latent-class trajectories of activities of daily living
Han L, Allore H, Murphy T, Gill T, Peduzzi P, Lin H. Dynamics of functional aging based on latent-class trajectories of activities of daily living. Annals Of Epidemiology 2013, 23: 87-92. PMID: 23305692, PMCID: PMC3558979, DOI: 10.1016/j.annepidem.2012.11.010.Peer-Reviewed Original ResearchConceptsDaily livingFunctional agingCommunity-living adultsEquation Poisson modelsMost older adultsADL disabilityHigher disabilityPersistent disabilitySubstantial morbidityInstrumental ADLADL independenceDisability trajectoriesLatent class trajectoriesCumulative burdenRestricted activityLow burdenSevere disabilityMorbidityPredominant trajectoriesOlder adultsDisabilityTime trendsFunctional autonomyADLGrowth mixture modelsComparisons Between Older Men and Women in the Trajectory and Burden of Disability Over the Course of Nearly 14 Years
Gill TM, Gahbauer EA, Lin H, Han L, Allore HG. Comparisons Between Older Men and Women in the Trajectory and Burden of Disability Over the Course of Nearly 14 Years. Journal Of The American Medical Directors Association 2013, 14: 280-286. PMID: 23294968, PMCID: PMC3615123, DOI: 10.1016/j.jamda.2012.11.011.Peer-Reviewed Original ResearchConceptsBurden of disabilityOlder menModerate disabilityGender differencesWorse disabilityDisability trajectoriesClinical covariatesDaily livingOlder womenBaseline levelsHigh mortalityGreater burdenSevere disabilityMonthly interviewsLife course approachWomenMild disabilityDisabilityBasic activitiesLongitudinal studyMenMobility activitiesHigh rateHigher initial levelsBurden
2009
Factors Associated With Recovery of Prehospital Function Among Older Persons Admitted to a Nursing Home With Disability After an Acute Hospitalization
Gill TM, Gahbauer EA, Han L, Allore HG. Factors Associated With Recovery of Prehospital Function Among Older Persons Admitted to a Nursing Home With Disability After an Acute Hospitalization. The Journals Of Gerontology Series A 2009, 64A: 1296-1303. PMID: 19661289, PMCID: PMC2773809, DOI: 10.1093/gerona/glp115.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAge FactorsAgedAged, 80 and overCohort StudiesContinuity of Patient CareDisability EvaluationDisabled PersonsFemaleFollow-Up StudiesGeriatric AssessmentHomes for the AgedHospitalizationHumansKaplan-Meier EstimateLongitudinal StudiesMaleMultivariate AnalysisNursing HomesPatient DischargeProbabilityProportional Hazards ModelsRecovery of FunctionRisk FactorsTime FactorsUnited StatesConceptsNursing home admissionPrehospital functionHome admissionAcute hospitalizationSignificant weight lossNursing homesGross motor coordinationMotor coordinationOlder personsManual dexterityWeight lossMonthly telephone interviewsOngoing cohort studyCohort studyFunctional recoveryPrehospital levelMore admissionsDaily livingHospitalizationAdmissionCognitive impairmentMultivariate analysisTelephone interviewsPotential predictorsAnalytic sample
2007
Bath Aids and the Subsequent Development of Bathing Disability in Community‐Living Older Persons
Gill TM, Han L, Allore HG. Bath Aids and the Subsequent Development of Bathing Disability in Community‐Living Older Persons. Journal Of The American Geriatrics Society 2007, 55: 1757-1763. PMID: 17916117, PMCID: PMC2778072, DOI: 10.1111/j.1532-5415.2007.01421.x.Peer-Reviewed Original ResearchEffects of Statin Use on Muscle Strength, Cognition, and Depressive Symptoms in Older Adults
Agostini JV, Tinetti ME, Han L, McAvay G, Foody JM, Concato J. Effects of Statin Use on Muscle Strength, Cognition, and Depressive Symptoms in Older Adults. Journal Of The American Geriatrics Society 2007, 55: 420-425. PMID: 17341246, DOI: 10.1111/j.1532-5415.2007.01071.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCognitionCohort StudiesComorbidityConnecticutDepressionDrug Therapy, CombinationDrug UtilizationFemaleGeriatric AssessmentHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLongitudinal StudiesMaleMuscle StrengthNeuropsychological TestsPrimary Health CareProspective StudiesRisk AssessmentVeteransConceptsStatin usersMuscle strengthTest Part BStatin useDepression scoresEpidemiologic Studies Depression Scale scoreOutpatient primary care clinicsOlder adultsConcomitant medication useProximal muscle strengthObservational cohort studyPeripheral vascular diseasePrimary care clinicsDepression Scale scoresHigh-risk participantsHydroxymethyl glutaryl coenzymeCommunity-dwelling veteransCommunity-dwelling male participantsGreater comorbidityStatin therapyCohort studyMedian durationStatin prescriptionMedication useCare clinicsPredisposing Factors and Precipitants for Bathing Disability in Older Persons
Gill TM, Han L, Allore HG. Predisposing Factors and Precipitants for Bathing Disability in Older Persons. Journal Of The American Geriatrics Society 2007, 55: 534-540. PMID: 17397431, DOI: 10.1111/j.1532-5415.2007.01099.x.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overBathsConnecticutFemaleGeriatric AssessmentHealth StatusHumansLongitudinal StudiesMaleRisk FactorsConceptsBathing disabilityPersistent disabilityPredisposing factorsPotential precipitantsComprehensive home-based assessmentsOlder personsCommunity-living older personsCommunity-living residentsMultivariable hazard ratiosProspective cohort studyLow physical activityMonthly telephone interviewsPotential predisposing factorsHome-based assessmentCohort studyHazard ratioPhysical activityRestricted activityTelephone interviewsStrong associationDisabilityHospitalizationInjuryIllnessSuitable target
2004
Modifiable Risk Factors for Nursing Home-Acquired Pneumonia
Quagliarello V, Ginter S, Han L, Van Ness P, Allore H, Tinetti M. Modifiable Risk Factors for Nursing Home-Acquired Pneumonia. Clinical Infectious Diseases 2004, 40: 1-6. PMID: 15614684, DOI: 10.1086/426023.Peer-Reviewed Original ResearchMeSH KeywordsAgedCommunity-Acquired InfectionsGeriatric AssessmentHumansNursing HomesPneumoniaRisk FactorsConceptsModifiable risk factorsElderly nursing home residentsInadequate oral careNursing home residentsCox proportional hazards modelCases of pneumoniaRisk factorsProportional hazards modelOral careHome residentsSurveillance periodHazards modelCandidate modifiable risk factorNursing Home-Acquired PneumoniaPneumonia prevention strategiesRisk of pneumoniaPrimary outcomeSwallowing difficultiesIndependent associationAttributable fractionPneumoniaNursing homesPrevention strategiesElderly residentsSame covariates
2003
An Empirical Study of Different Diagnostic Criteria for Delirium Among Elderly Medical Inpatients
Cole MG, Dendukuri N, McCusker J, Han L. An Empirical Study of Different Diagnostic Criteria for Delirium Among Elderly Medical Inpatients. Journal Of Neuropsychiatry 2003, 15: 200-207. PMID: 12724462, DOI: 10.1176/jnp.15.2.200.Peer-Reviewed Original ResearchAgedAged, 80 and overConfusionDeliriumDementiaDiagnosis, DifferentialDiagnostic and Statistical Manual of Mental DisordersEmpirical ResearchFemaleGeriatric AssessmentHumansInpatientsInternational Classification of DiseasesMaleProspective StudiesPsychiatric Status Rating ScalesRandomized Controlled Trials as TopicReproducibility of ResultsSensitivity and Specificity
2001
Environmental Risk Factors for Delirium in Hospitalized Older People
McCusker J, Cole M, Abrahamowicz M, Han L, Podoba J, Ramman‐Haddad L. Environmental Risk Factors for Delirium in Hospitalized Older People. Journal Of The American Geriatrics Society 2001, 49: 1327-1334. PMID: 11890491, DOI: 10.1046/j.1532-5415.2001.49260.x.Peer-Reviewed Original ResearchConceptsEnvironmental risk factorsRisk factorsPhysical restraintDelirium symptomsSeverity scoreHospital unitsObservational prospective clinical studyPrior cognitive impairmentSymptoms of deliriumConfusion Assessment MethodModifiable risk factorsGeneral community hospitalProspective clinical studyPatients age 65Potential environmental risk factorsSymptom severity scoresHospitalized older peopleDelirium severity scoresMedical wardsPatient characteristicsDelirium IndexIntensive careInitial severityCommunity hospitalClinical studies