Featured Publications
Cumulative Anticholinergic Exposure Is Associated with Poor Memory and Executive Function in Older Men
Han L, Agostini JV, Allore HG. Cumulative Anticholinergic Exposure Is Associated with Poor Memory and Executive Function in Older Men. Journal Of The American Geriatrics Society 2008, 56: 2203-2210. PMID: 19093918, PMCID: PMC3952110, DOI: 10.1111/j.1532-5415.2008.02009.x.Peer-Reviewed Original ResearchConceptsTotal anticholinergic burdenCumulative anticholinergic exposureOlder menAnticholinergic medicationsAnticholinergic burdenAnticholinergic exposureCumulative exposureVeterans Affairs primary care clinicsExecutive functionAnticholinergic medication useDeleterious adverse effectsProspective cohort studySeverity of hypertensionCommunity-dwelling menPrimary care clinicsDaily Living ScalePotential risk factorsPrescription of drugsAnticholinergic scoreCohort studyMultiple medicationsAnticholinergic effectsMedication useCare clinicsPhysical function
2014
Epidemiology of Restricting Fatigue in Older Adults: The Precipitating Events Project
de Rekeneire N, Leo‐Summers L, Han L, Gill TM. Epidemiology of Restricting Fatigue in Older Adults: The Precipitating Events Project. Journal Of The American Geriatrics Society 2014, 62: 476-481. PMID: 24512073, PMCID: PMC4103720, DOI: 10.1111/jgs.12685.Peer-Reviewed Original ResearchConceptsCommunity-living older adultsPhysical frailtyOlder adultsCommunity-living older menEpidemiologic Studies Depression ScaleProspective cohort studySlow gait speedOverall incidence ratePrecipitating Events ProjectCohort studyCumulative incidenceMedian durationGait speedIncidence rateDepression ScaleUsual activitiesOlder menFrailtyDepressionMonthsWomenConsecutive monthsAdultsHigh rateRespective counterparts
2013
Comparisons Between Older Men and Women in the Trajectory and Burden of Disability Over the Course of Nearly 14 Years
Gill TM, Gahbauer EA, Lin H, Han L, Allore HG. Comparisons Between Older Men and Women in the Trajectory and Burden of Disability Over the Course of Nearly 14 Years. Journal Of The American Medical Directors Association 2013, 14: 280-286. PMID: 23294968, PMCID: PMC3615123, DOI: 10.1016/j.jamda.2012.11.011.Peer-Reviewed Original ResearchConceptsBurden of disabilityOlder menModerate disabilityGender differencesWorse disabilityDisability trajectoriesClinical covariatesDaily livingOlder womenBaseline levelsHigh mortalityGreater burdenSevere disabilityMonthly interviewsLife course approachWomenMild disabilityDisabilityBasic activitiesLongitudinal studyMenMobility activitiesHigh rateHigher initial levelsBurden
2011
Antidepressant Use and Cognitive Deficits in Older Men: Addressing Confounding by Indications with Different Methods
Han L, Kim N, Brandt C, Allore HG. Antidepressant Use and Cognitive Deficits in Older Men: Addressing Confounding by Indications with Different Methods. Annals Of Epidemiology 2011, 22: 9-16. PMID: 22037381, PMCID: PMC4054866, DOI: 10.1016/j.annepidem.2011.10.004.Peer-Reviewed Original ResearchConceptsDepression-related diagnosisAntidepressant useDepression symptomsOlder personsPropensity scoreHopkins Verbal Learning TestHypertensive menAntidepressant medicationIndication biasVerbal Learning TestMedical recordsPotential confoundingCumulative exposureOlder menCognitive impairmentMemory deficitsCognitive deficitsMultiple linear regressionLinear regressionLearning TestApparent associationScoresSymptomsDiagnosisIndicationsEpidemiology of Restricting Back Pain in Community‐Living Older Persons
Makris UE, Fraenkel L, Han L, Leo‐Summers L, Gill TM. Epidemiology of Restricting Back Pain in Community‐Living Older Persons. Journal Of The American Geriatrics Society 2011, 59: 610-614. PMID: 21410444, PMCID: PMC3098613, DOI: 10.1111/j.1532-5415.2011.03329.x.Peer-Reviewed Original ResearchConceptsCommunity-living older personsCumulative incidenceBack painIncidence rateOlder personsFirst episodeBaseline age groupProspective cohort studyKaplan-Meier methodCommunity-living menPoisson regression modelsCohort studyMedian durationMedian timeDescriptive epidemiologyTotal episodesOlder womenPainOlder menAge groupsRestricted activityIncidenceWomenMenConsecutive months
2007
Association Between Antihypertensive Medication Use and Non-cardiovascular Outcomes in Older Men
Agostini JV, Tinetti ME, Han L, Peduzzi P, Foody JM, Concato J. Association Between Antihypertensive Medication Use and Non-cardiovascular Outcomes in Older Men. Journal Of General Internal Medicine 2007, 22: 1661-1667. PMID: 17899299, PMCID: PMC2219823, DOI: 10.1007/s11606-007-0388-9.Peer-Reviewed Original ResearchConceptsNon-cardiovascular outcomesAntihypertensive medication useAntihypertensive medicationsMedication useAdverse effectsOlder menCommunity-living older menVeterans Affairs primary care clinicsEpidemiologic Studies-Depression scoreOlder adultsMultiple antihypertensive medicationsPhysical performancePrimary care clinicsDrug adverse effectsRoutine clinical practiceCES-D scoresHigh cumulative exposureRelated adverse effectsTrail Making BMedication intensityTest Part BHypertensive menCerebrovascular effectsCohort studyBlood pressure