2002
Prolonged Activation of Ca2+-Activated K+Current Contributes to the Long-Lasting Refractory Period ofAplysia Bag Cell Neurons
Zhang Y, Magoski NS, Kaczmarek LK. Prolonged Activation of Ca2+-Activated K+Current Contributes to the Long-Lasting Refractory Period ofAplysia Bag Cell Neurons. Journal Of Neuroscience 2002, 22: 10134-10141. PMID: 12451114, PMCID: PMC6758731, DOI: 10.1523/jneurosci.22-23-10134.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAplysiaCalciumCells, CulturedElectric StimulationEnzyme ActivatorsEnzyme InhibitorsLarge-Conductance Calcium-Activated Potassium ChannelsNeural InhibitionNeuronsPatch-Clamp TechniquesPhloretinPotassiumPotassium Channel BlockersPotassium Channels, Calcium-ActivatedProtein Kinase CRefractory Period, ElectrophysiologicalSphingosineTetradecanoylphorbol AcetateConceptsBag cell neuronsCell neuronsRefractory periodBK currentsProtein kinase COnset of afterdischargeBK channel activityApplication of phloretinBK channel activatorsProlonged refractory periodAbility of stimulationRole of Ca2Blocker paxillinePharmacological characteristicsChannel activatorIntracellular Ca2Prolonged increaseOutward currentsInhibitor of PKCAfterdischargesNeuronsAdditional stimulationProlonged activationActivator of PKCChannel activity
1994
Transient changes in intracellular calcium associated with a prolonged increase in excitability in neurons of Aplysia californica
Fisher T, Levy S, Kaczmarek L. Transient changes in intracellular calcium associated with a prolonged increase in excitability in neurons of Aplysia californica. Journal Of Neurophysiology 1994, 71: 1254-1257. PMID: 8201416, DOI: 10.1152/jn.1994.71.3.1254.Peer-Reviewed Original ResearchConceptsIntracellular calcium levelsBag cell neuronsCalcium levelsSpontaneous firingCell neuronsIntracellular calciumAction potentialsTransient elevationBasal intracellular calcium levelsLong-duration action potentialsBasal calcium levelsFree calcium ion concentrationTriggers calcium releaseCalcium-sensitive microelectrodesAplysia californicaIndividual action potentialsAfferent stimulationAfferent inputAfterdischargesProlonged increaseCalcium releaseCalcium ion concentrationNeuronsBiphasic patternPrimary cultures