2015
Kv3.3 potassium channels and spinocerebellar ataxia
Zhang Y, Kaczmarek LK. Kv3.3 potassium channels and spinocerebellar ataxia. The Journal Of Physiology 2015, 594: 4677-4684. PMID: 26442672, PMCID: PMC4983625, DOI: 10.1113/jp271343.Peer-Reviewed Original ResearchConceptsPurkinje cellsPotassium channelsAuditory brainstem nucleiCentral nervous systemUnique neurodegenerative diseaseCerebellar Purkinje cellsVoltage-dependent potassium channelsSpinocerebellar ataxia type 13Neuronal survivalBrainstem nucleiExtracerebellar symptomsCerebellar degenerationNervous systemNeurodegenerative diseasesComplex spikesNormal functionKv3.3Disease-causing mutationsType 13Kv3.3 potassium channelSpinocerebellar ataxiaHigh rateCerebellumDifferent mutationsPhysiological functionsNeurotransmitters and Neurohormones
Levitan I, Kaczmarek L. Neurotransmitters and Neurohormones. 2015, 213-238. DOI: 10.1093/med/9780199773893.003.0010.ChaptersNervous systemNearby glial cellsRole of neurotransmittersSpecific transporter proteinsExtracellular spaceGlial cellsNerve terminalsPresynaptic terminalsTransporter proteinsIntercellular communicationTarget cellsGreat diversityNeuropeptidesNeurotransmittersMultitude of chemicalsCellsAcetylcholineReuptakeCatecholaminesGABANeuronsNeurohormonesThe Birth and Death of a Neuron
Levitan I, Kaczmarek L. The Birth and Death of a Neuron. 2015, 329-352. DOI: 10.1093/med/9780199773893.003.0014.ChaptersNervous systemComplement of genesOuter mitochondrial membraneBone morphogenetic proteinNew neuronsNeuronal determinationTranscription factorsMitochondrial membraneBrain regionsMorphogenetic proteinsNeural inducersSpecific neuronsNeuronsEarly stepsNormal formationAction of factorsHigh rateDeathBirthVariety of factorsCellsFactorsGenesLearning and Memory
Levitan I, Kaczmarek L. Learning and Memory. 2015, 489-528. DOI: 10.1093/med/9780199773893.003.0019.ChaptersSimple nervous systemLong-term depressionLong-term potentiationMolecular mechanismsEnormous diversityNormal developmentCellular mechanismsNervous systemPresynaptic terminalsMost nervous systemsCyclic AMPSynaptic scalingPathwayMemory formationPlasticityPostsynaptic receptorsSynaptic taggingSynaptic connectionsLong-term phaseReduced preparationsDiversitySpike-timing dependent plasticityMechanismSynapseReceptorsNeuronal Growth and Trophic Factors
Levitan I, Kaczmarek L. Neuronal Growth and Trophic Factors. 2015, 353-386. DOI: 10.1093/med/9780199773893.003.0015.ChaptersMolecular genetic approachesMature nervous systemGrowth factorNeuronal determinationTranscription factorsGenetic approachesKey growth factorsNeural developmentStem cellsTypes of neuronsNearby cellsNeuronal growthMechanism of actionMedical therapySympathetic neuronsMotor neuronsTrophic factorsNervous systemSteroid hormonesNeuronsDrosophilaCellsDevelopmental factorsGeneticsDifferentiation
2013
Slack, Slick, and Sodium‐Activated Potassium Channels
Kaczmarek LK. Slack, Slick, and Sodium‐Activated Potassium Channels. International Scholarly Research Notices 2013, 2013: 354262. PMID: 24319675, PMCID: PMC3850776, DOI: 10.1155/2013/354262.Peer-Reviewed Original ResearchSodium-activated potassium currentPotassium channelsMore action potentialsCentral nervous systemAMPA receptorsNeuronal plasticityNative neuronsNervous systemNeurotransmitter receptorsSlick channelsIntracellular sodiumPotassium currentAction potentialsIntellectual functionSlack channelsReceptorsHuman mutationsSevere defectsCentral roleNeurons
2012
An evolutionarily conserved mode of modulation of Shaw‐like K+ channels
Cotella D, Hernandez‐Enriquez B, Duan Z, Wu X, Gazula V, Brown MR, Kaczmarek LK, Sesti F. An evolutionarily conserved mode of modulation of Shaw‐like K+ channels. The FASEB Journal 2012, 27: 1381-1393. PMID: 23233530, PMCID: PMC3606535, DOI: 10.1096/fj.12-222778.Peer-Reviewed Original ResearchConceptsEffect of phosphorylationC. elegansACP-2Acid phosphataseMammalian homologMammalian homologueCaenorhabditis elegansMouse nervous systemRegulatory partnersBiochemical experimentsMolecular mechanismsElegansBehavioral defectsMode of modulationPhosphorylationPharmacological disruptionShaw familyMammalian brainSubset of neuronsVentricular zonePhosphataseModel systemNervous systemMice resultsElectrophysiological analysis
2008
Protein Kinase C Modulates Inactivation of Kv3.3 Channels*
Desai R, Kronengold J, Mei J, Forman SA, Kaczmarek LK. Protein Kinase C Modulates Inactivation of Kv3.3 Channels*. Journal Of Biological Chemistry 2008, 283: 22283-22294. PMID: 18539595, PMCID: PMC2494927, DOI: 10.1074/jbc.m801663200.Peer-Reviewed Original ResearchRepetitive Firing Triggers Clustering of Kv2.1 Potassium Channels in Aplysia Neurons*
Zhang Y, McKay SE, Bewley B, Kaczmarek LK. Repetitive Firing Triggers Clustering of Kv2.1 Potassium Channels in Aplysia Neurons*. Journal Of Biological Chemistry 2008, 283: 10632-10641. PMID: 18276591, DOI: 10.1074/jbc.m800253200.Peer-Reviewed Original ResearchConceptsBag cell neuronsKv2.1 channelsPotassium channelsPlasma membraneC-terminusKv2.1 clustersKv2.1 potassium channelCell neuronsMammalian neuronsReproductive behaviorRectifier potassium channelFrequency-dependent broadeningRapid redistributionAplysia neuronsClamp recordingsAcid peptidePartial inactivationRing-like clustersPhysiological changesKv2.1Neuronal excitabilityCentral nervous systemAction potentialsGenesNervous system
2006
Modulation of Kv3.1b Potassium Channel Phosphorylation in Auditory Neurons by Conventional and Novel Protein Kinase C Isozymes*
Song P, Kaczmarek LK. Modulation of Kv3.1b Potassium Channel Phosphorylation in Auditory Neurons by Conventional and Novel Protein Kinase C Isozymes*. Journal Of Biological Chemistry 2006, 281: 15582-15591. PMID: 16595659, DOI: 10.1074/jbc.m512866200.Peer-Reviewed Original ResearchConceptsAuditory neuronsMNTB neuronsTrapezoid bodyBrief high-frequency electrical stimulationProtein kinase CMetabotropic glutamate receptor activationHigh-frequency electrical stimulationBasal phosphorylationGlutamate receptor activationHigh-frequency stimulationFrequency electrical stimulationHigh-frequency firingMature nervous systemKv3.1 potassium channelNeuronal abilityBrainstem slicesMedial nucleusFrequency stimulationAuditory brainstemFrequency firingConventional protein kinase CPharmacological activationNervous systemElectrical stimulationPKC isozymes
2005
Localization of the Na+‐activated K+ channel Slick in the rat central nervous system
Bhattacharjee A, von Hehn CA, Mei X, Kaczmarek LK. Localization of the Na+‐activated K+ channel Slick in the rat central nervous system. The Journal Of Comparative Neurology 2005, 484: 80-92. PMID: 15717307, DOI: 10.1002/cne.20462.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAuditory PathwaysCentral Nervous SystemCHO CellsComputer SimulationCricetinaeDNA, ComplementaryFacial NerveImmunoblottingImmunohistochemistryIn Situ HybridizationKineticsModels, NeurologicalNeuronsOlfactory BulbPotassium ChannelsPotassium Channels, Sodium-ActivatedRatsReverse Transcriptase Polymerase Chain ReactionRNA ProbesSubcellular FractionsConceptsRat central nervous systemCentral nervous systemNervous systemAuditory neuronsCortical layers IIHigh-frequency stimulationLow-frequency firingDeep cerebellar nucleiSubstantia nigraTrapezoid bodyVestibular nucleiHippocampal CA1Dentate gyrusMedial nucleusCA3 regionOculomotor nucleusCertain neuronsFacial nucleusNeuronal nucleiOlfactory bulbPontine nucleiImmunohistochemical techniquesRed nucleusLayers IISupraoptic nucleus
2002
Localization of the Slack potassium channel in the rat central nervous system
Bhattacharjee A, Gan L, Kaczmarek LK. Localization of the Slack potassium channel in the rat central nervous system. The Journal Of Comparative Neurology 2002, 454: 241-254. PMID: 12442315, DOI: 10.1002/cne.10439.Peer-Reviewed Original ResearchConceptsRat central nervous systemSlack potassium channelsChannel subunitsRat brain slicesCentral nervous systemRat brain membranesOnly cortical regionDeep cerebellar nucleiGiant presynaptic terminalSlo subunitWestern blot analysisSubstantia nigraTrigeminal systemImmunohistochemical studyMedial nucleusOculomotor nucleusReticular formationBrain slicesFrontal cortexOlfactory bulbPresynaptic terminalsRed nucleusNervous systemCerebellar nucleiBrain membranes
2001
Neurotransmitters and Neurohormones
B.Levitan I, Kaczmarek L. Neurotransmitters and Neurohormones. 2001, 223-252. DOI: 10.1093/oso/9780195145236.003.0010.Peer-Reviewed Original ResearchReceptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels
B.Levitan I, Kaczmarek L. Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels. 2001, 253-284. DOI: 10.1093/oso/9780195145236.003.0011.Peer-Reviewed Original ResearchTarget neuronsIon channelsParticular neurotransmitterNeuroactive substancesTransmitter releaseNervous systemNeurotransmitter receptorsNerve cellsHormone receptorsNeuronsTarget cellsReceptorsBiological responsesNeurotransmittersIntercellular communicationCell typesExtracellular signalsChemical signalsTransduction mechanismsResponseCellsNeurohormonesThe Birth and Death of a Neuron
B.Levitan I, Kaczmarek L. The Birth and Death of a Neuron. 2001, 375-394. DOI: 10.1093/oso/9780195145236.003.0015.Peer-Reviewed Original ResearchNervous systemNeuronal developmentProfound plastic changesAdult nerve cellsGrowth of axonsConnections of neuronsImmature neuronsSynaptic contactsNew neuronsNeuronal plasticityDendritic processesNeuronal formPlastic changesSynaptic connectionsNerve cellsNeuronal structuresNeuronsAdult animalsSelect groupDeathAdultsNormal courseCellsEarly stepsAxonsNeuronal Growth and Trophic Factors
B.Levitan I, Kaczmarek L. Neuronal Growth and Trophic Factors. 2001, 395-434. DOI: 10.1093/oso/9780195145236.003.0016.Peer-Reviewed Original ResearchAdhesion Molecules and Axon Pathfinding
B.Levitan I, Kaczmarek L. Adhesion Molecules and Axon Pathfinding. 2001, 435-466. DOI: 10.1093/oso/9780195145236.003.0017.Peer-Reviewed Original ResearchNervous systemNeuronal activityDendritic branchesSuperior cervical ganglionDendritic branching patternsMature nervous systemTypes of synapsesIntact nervous systemCervical ganglionLong-term regulationSynaptic connectionsIntact animalsNeuronal structuresAdhesion moleculesNeuronsElectrical activityGangliaFluorescent cellsBranching patternDendritesCellsSpecific patternsAxonsMiceActivityFormation, Maintenance, and Plasticity of Chemical Synapses
B.Levitan I, Kaczmarek L. Formation, Maintenance, and Plasticity of Chemical Synapses. 2001, 467-506. DOI: 10.1093/oso/9780195145236.003.0018.Peer-Reviewed Original ResearchNervous systemSynaptic connectionsFormation of synapsesAdult nervous systemSpecific synaptic connectionsImmature neuronsSynaptic contactsAdult neuronsMature neuronsElectrical stimulationSynaptic plasticityNeuronal formBrain functionChemical synapsesNeuronsElectrical activityNeurite elongationSynaptogenesisSynapsesProperties of cellsNeural Networks and Behavior
B.Levitan I, Kaczmarek L. Neural Networks and Behavior. 2001, 507-536. DOI: 10.1093/oso/9780195145236.003.0019.Peer-Reviewed Original Research