2014
Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels
El-Hassar L, Simen AA, Duque A, Patel KD, Kaczmarek LK, Arnsten AF, Yeckel MF. Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels. Biological Psychiatry 2014, 76: 476-485. PMID: 24560582, PMCID: PMC4104266, DOI: 10.1016/j.biopsych.2013.12.019.Peer-Reviewed Original ResearchConceptsCyclic adenosine monophosphateIntracellular Ca2Prefrontal cortical pyramidal neuronsReceptor-mediated intracellular Ca2Regulation of cAMPPrefrontal cortical slicesCortical pyramidal neuronsDISC1 functionMajor depressive disorderPyramidal neuron activityPatch-clamp recordingsTRPC channel activityDISC1 disruptionPrefrontal cortex activityPyramidal neuronsCortical slicesDepressive disorderAdult ratsIntracellular calcium wavesSustained depolarizationViral knockdownNeuron activityBipolar disorderMental disordersCAMP generation
2002
Prolonged Activation of Ca2+-Activated K+Current Contributes to the Long-Lasting Refractory Period ofAplysia Bag Cell Neurons
Zhang Y, Magoski NS, Kaczmarek LK. Prolonged Activation of Ca2+-Activated K+Current Contributes to the Long-Lasting Refractory Period ofAplysia Bag Cell Neurons. Journal Of Neuroscience 2002, 22: 10134-10141. PMID: 12451114, PMCID: PMC6758731, DOI: 10.1523/jneurosci.22-23-10134.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAplysiaCalciumCells, CulturedElectric StimulationEnzyme ActivatorsEnzyme InhibitorsLarge-Conductance Calcium-Activated Potassium ChannelsNeural InhibitionNeuronsPatch-Clamp TechniquesPhloretinPotassiumPotassium Channel BlockersPotassium Channels, Calcium-ActivatedProtein Kinase CRefractory Period, ElectrophysiologicalSphingosineTetradecanoylphorbol AcetateConceptsBag cell neuronsCell neuronsRefractory periodBK currentsProtein kinase COnset of afterdischargeBK channel activityApplication of phloretinBK channel activatorsProlonged refractory periodAbility of stimulationRole of Ca2Blocker paxillinePharmacological characteristicsChannel activatorIntracellular Ca2Prolonged increaseOutward currentsInhibitor of PKCAfterdischargesNeuronsAdditional stimulationProlonged activationActivator of PKCChannel activity
2000
Activation of a Ca2+‐permeable cation channel produces a prolonged attenuation of intracellular Ca2+ release in Aplysia bag cell neurones
Magoski N, Knox R, Kaczmarek L. Activation of a Ca2+‐permeable cation channel produces a prolonged attenuation of intracellular Ca2+ release in Aplysia bag cell neurones. The Journal Of Physiology 2000, 522: 271-283. PMID: 10639103, PMCID: PMC2269759, DOI: 10.1111/j.1469-7793.2000.t01-2-00271.x.Peer-Reviewed Original ResearchConceptsVoltage-gated Ca2Non-selective cation channelsRefractory periodCation channelsElectrical stimulationFree salineAbility of nifedipinePresence of nifedipinePresence of TTXIntact abdominal gangliaProlonged refractory periodOnset of refractorinessAfferent inputBrief synaptic stimulationHigh external potassiumPermeable cation channelIntracellular calciumAbdominal ganglionExtracellular Ca2Synaptic stimulationAfterdischargesNormal responseIntracellular Ca2Intracellular storesRepeated stimulation
1997
Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion
Jonas E, Knox R, Smith T, Wayne N, Connor J, Kaczmarek L. Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion. Nature 1997, 385: 343-346. PMID: 9002519, DOI: 10.1038/385343a0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoquinonesCalciumCalcium ChannelsCells, CulturedCyclic AMPEndoplasmic ReticulumHeparinInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsInsulinInvertebrate HormonesLactams, MacrocyclicNeuronsNeuropeptidesProtein-Tyrosine KinasesQuinonesReceptors, Cytoplasmic and NuclearRifabutinThapsigarginConceptsIntracellular Ca2Neuropeptide secretionSpontaneous action potentialsEffect of insulinSecretion of neuropeptidesTyrosine kinase receptorsAcute riseBag cell neuronsDistal tipNeuronal dischargeNeuronal Ca2Distinct intracellular poolsCell neuronsAction potentialsCyclic AMP analogueInsulinNeuropeptidesInsulin receptorKinase receptorsSecretionPresumed siteNeuronsIntracellular poolMitochondrial Ca2Receptors
1996
Ca2+ influx and activation of a cation current are coupled to intracellular Ca2+ release in peptidergic neurons of Aplysia californica.
Knox RJ, Jonas EA, Kao LS, Smith PJ, Connor JA, Kaczmarek LK. Ca2+ influx and activation of a cation current are coupled to intracellular Ca2+ release in peptidergic neurons of Aplysia californica. The Journal Of Physiology 1996, 494: 627-639. PMID: 8865062, PMCID: PMC1160665, DOI: 10.1113/jphysiol.1996.sp021520.Peer-Reviewed Original ResearchConceptsBag cell neuronsCell neuronsThapsigargin-sensitive Ca2Cation currentReversal potentialVoltage-activated Ba2Non-selective cation currentAplysia californicaApparent reversal potentialSteady-state Ca2Thapsigargin-induced elevationMin. 3Endoplasmic reticulum Ca2Voltage-clamp experimentsMicroM tetrodotoxinPeptidergic neuronsIntact gangliaAbdominal ganglionExtracellular Ca2Intracellular Ca2Intracellular storesBAPTA-AMSmall depolarizationBasal levelsNeurons
1991
Neuropeptide inhibition of voltage-gated calcium channels mediated by mobilization of intracellular calcium
Kramer R, Kaczmarek L, Levitan E. Neuropeptide inhibition of voltage-gated calcium channels mediated by mobilization of intracellular calcium. Neuron 1991, 6: 557-563. PMID: 1849723, DOI: 10.1016/0896-6273(91)90058-8.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneVoltage-gated calcium channelsVoltage-gated Ca2Protein kinase CInactivation of Ca2Pituitary tumor cellsVariety of agentsHormone secretionNeurotransmitter inhibitionIntracellular calciumResult of Ca2Calcium channelsIntracellular Ca2Inhibits Ca2Kinase CEndocrine cellsRoutine useTumor cellsPatch-clamp electrodesPlasma membrane channelsDependent inactivationInhibitionHormoneSecretionCa2