Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses
Goffin D, Allen M, Zhang L, Amorim M, Wang IT, Reyes AR, Mercado-Berton A, Ong C, Cohen S, Hu L, Blendy JA, Carlson GC, Siegel SJ, Greenberg ME, Zhou Z. Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses. Nature Neuroscience 2011, 15: 274-283. PMID: 22119903, PMCID: PMC3267879, DOI: 10.1038/nn.2997.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAge FactorsAlanineAnimalsCells, CulturedCerebral CortexChromatin ImmunoprecipitationConditioning, PsychologicalDNA Mutational AnalysisDNA-Binding ProteinsElectroencephalographyEmbryo, MammalianEvoked Potentials, Auditory, Brain StemExploratory BehaviorFearGene Expression RegulationHumansMaze LearningMethyl-CpG-Binding Protein 2MiceMice, Inbred C57BLMice, TransgenicMotor ActivityMutationNeuronsSpectrum AnalysisThreonineHistone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice
Krishnan V, Chow MZ, Wang Z, Zhang L, Liu B, Liu X, Zhou Z. Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 12325-12330. PMID: 21746928, PMCID: PMC3145730, DOI: 10.1073/pnas.1102789108.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAgingAging, PrematureAnimalsCells, CulturedCellular SenescenceChromosomal Proteins, Non-HistoneDisease Models, AnimalDNA RepairDNA-Binding ProteinsHistone AcetyltransferasesHistone Deacetylase InhibitorsHistonesHumansLamin Type ALysineMembrane ProteinsMetalloendopeptidasesMiceMice, KnockoutNuclear MatrixNuclear ProteinsProtein PrecursorsRNA, Small InterferingTumor Suppressor p53-Binding Protein 1ConceptsDNA damage responseHutchinson-Gilford progeria syndromeDamage responseProgeria syndromeRepair protein recruitmentDNA damage sitesZmpste24-deficient miceAge-associated phenotypesDefective DNA repairChromatin modificationsProtein recruitmentEpigenetic marksHistone H4Histone acetyltransferaseNuclear matrixSpecific point mutationsDNA repairLamin AGenomic instabilityEpigenetic changesRepair proteinsHistone deacetylase inhibitorsCellular senescenceMOF overexpressionMolecular mechanisms