2003
MRI and PET Study of Deficits in Hippocampal Structure and Function in Women With Childhood Sexual Abuse and Posttraumatic Stress Disorder
Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Nazeer A, Khan S, Vaccarino LV, Soufer R, Garg PK, Ng CK, Staib LH, Duncan JS, Charney DS. MRI and PET Study of Deficits in Hippocampal Structure and Function in Women With Childhood Sexual Abuse and Posttraumatic Stress Disorder. American Journal Of Psychiatry 2003, 160: 924-932. PMID: 12727697, DOI: 10.1176/appi.ajp.160.5.924.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderChildhood sexual abuseHippocampal volumeEarly childhood sexual abuseHippocampal structureHippocampal functionAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesPositron emission tomographySexual abuseVerbal declarative memory tasksAnimal studiesBrain areasDeclarative memory taskEmission tomographyPET studiesHippocampal activationWomenEarly stressHippocampusAbused womenDisordersAbuseMagnetic resonanceNeural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse
Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Staib LH, Soufer R, Charney DS. Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse. Biological Psychiatry 2003, 53: 879-889. PMID: 12742675, DOI: 10.1016/s0006-3223(02)01891-7.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAbuse-related posttraumatic stress disorderMedial prefrontal cortexBrain areasPrefrontal cortexEarly childhood sexual abuseBlood flowChildhood abuse-related posttraumatic stress disorderSexual abuse-related posttraumatic stress disorderStress disorderChildhood sexual abuseCerebral blood flowPositron emission tomographic measurementsSpecific brain areasInferior temporal gyrusInferior parietal cortexMiddle frontal gyrusNeural correlatesTrauma-specific stimuliDeclarative memoryMotor cortexControl subjectsFrontal cortexSymptom provocationAnimal studies
2000
Hippocampal Volume Reduction in Major Depression
Bremner J, Narayan M, Anderson E, Staib L, Miller H, Charney D. Hippocampal Volume Reduction in Major Depression. American Journal Of Psychiatry 2000, 157: 115-118. PMID: 10618023, DOI: 10.1176/ajp.157.1.115.Peer-Reviewed Original ResearchConceptsSmaller left hippocampal volumeLeft hippocampal volumeHippocampal volumeMajor depressionComparison subjectsHippocampal volume reductionWhole brain volumeMagnetic resonance imagingNondepressed comparison subjectsAlcohol exposureBrain areasBrain volumeResonance imagingPatientsElevated levelsDepressionHippocampusVolume reductionComparison regionBrain sizeSubjectsRemissionGlucocorticoidsFindings
1999
Neural Correlates of Memories of Childhood Sexual Abuse in Women With and Without Posttraumatic Stress Disorder
Bremner J, Narayan M, Staib L, Southwick S, McGlashan T, Charney D. Neural Correlates of Memories of Childhood Sexual Abuse in Women With and Without Posttraumatic Stress Disorder. American Journal Of Psychiatry 1999, 156: 1787-1795. PMID: 10553744, PMCID: PMC3233772, DOI: 10.1176/ajp.156.11.1787.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderBlood flowVisual association cortexMedial prefrontal cortexChildhood sexual abusePrefrontal cortexMotor cortexAssociation cortexPosterior cingulateStress disorderBrain blood flowChildhood abuseInferior temporal gyrusPositron emission tomographyNeural correlatesSexual abuseSubcallosal gyrusRight hippocampusLong-term effectsFailure of activationAnterior prefrontal cortexBrain areasAnterior cingulateTraumatic remindersEmission tomographyNeural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study
Bremner J, Staib L, Kaloupek D, Southwick S, Soufer R, Charney D. Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study. Biological Psychiatry 1999, 45: 806-816. PMID: 10202567, PMCID: PMC3233761, DOI: 10.1016/s0006-3223(98)00297-2.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderNon-PTSD subjectsBlood flowVietnam combat veteransCerebral blood flow responseStress disorderBlood flow responsePositron emission tomography studySymptoms of patientsCerebral blood flowSubcortical brain areasEmission tomography studiesCombat veteransMedial prefrontal cortexPositron emission tomographyInferior parietal cortexNeural correlatesVisuospatial processingPTSD subjectsPTSD patientsBrain areasLingual gyrusAnterior cingulatePosterior cingulateParietal cortex