2024
Population attributable fraction of reproductive factors in triple negative breast cancer by race.
Jaber Chehayeb R, Odzer N, Albany R, Phipps A, Meisner A, Pusztai L. Population attributable fraction of reproductive factors in triple negative breast cancer by race. Journal Of Clinical Oncology 2024, 42: 10522-10522. DOI: 10.1200/jco.2024.42.16_suppl.10522.Peer-Reviewed Original ResearchPopulation-attributable fractionAA womenIncidence of triple negative breast cancerPooled odds ratioOdds ratioWhite womenTriple negative breast cancerNon-Hispanic White (WhiteRelative riskRace-specific odds ratiosBreast cancerIncidence rates of triple negative breast cancerEstimates of relative riskContribution of multiple risk factorsTNBC incidenceRelevant case-control studiesPopulation attributable fractionRisk factorsYounger ageNegative breast cancerCase-control studyMultiple risk factorsBreastfeeding uptakeAttributable fractionLevin's formula
2020
Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
Qing T, Mohsen H, Marczyk M, Ye Y, O’Meara T, Zhao H, Townsend JP, Gerstein M, Hatzis C, Kluger Y, Pusztai L. Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden. Nature Communications 2020, 11: 2438. PMID: 32415133, PMCID: PMC7228928, DOI: 10.1038/s41467-020-16293-7.Peer-Reviewed Original ResearchConceptsAge groupsGermline variantsSomatic mutationsLate-onset cancerEarly-onset cancersCancer hallmark genesSomatic mutation burdenMutation burdenMalignant transformationCancer genesYounger ageGermline alterationsCancerVariant burdenBurdenAverage numberHallmark genesAgeNegative correlationStrong negative correlationMutationsPatientsGroup
2010
Higher parity and shorter breastfeeding duration
Shinde SS, Forman MR, Kuerer HM, Yan K, Peintinger F, Hunt KK, Hortobagyi GN, Pusztai L, Symmans WF. Higher parity and shorter breastfeeding duration. Cancer 2010, 116: 4933-4943. PMID: 20665494, DOI: 10.1002/cncr.25443.Peer-Reviewed Original ResearchConceptsTriple-negative BCInvasive breast cancerDuration of breastfeedingBreast cancer phenotypeHigher parityOdds ratioBreast cancerTriple-negative breast cancer (TNBC) phenotypeConsecutive case seriesMultivariate logistic regressionConfidence intervalsAfrican American ethnicityCancer phenotypeShort durationCase seriesFamily historyNegative BCProgenitor cell populationsYounger ageLogistic regressionBreastfeedingAmerican ethnicityDemographic informationCell populationsAge
2005
A single-gene biomarker identifies breast cancers associated with immature cell type and short duration of prior breastfeeding
Symmans W, Fiterman D, Anderson S, Ayers M, Rouzier R, Dunmire V, Stec J, Valero V, Sneige N, Albarracin C, Wu Y, Ross J, Wagner P, Theriault R, Arun B, Kuerer H, Hess K, Zhang W, Hortobagyi G, Pusztai L. A single-gene biomarker identifies breast cancers associated with immature cell type and short duration of prior breastfeeding. Endocrine Related Cancer 2005, 12: 1059-1069. PMID: 16322343, DOI: 10.1677/erc.1.01051.Peer-Reviewed Original ResearchConceptsReal-time reverse transcription-polymerase chain reactionInvasive breast cancerImmature cell typesBreast cancerPrimary invasive breast cancerHigh-grade breast cancerMultivariate linear regression analysisReverse transcription-polymerase chain reactionCell typesTranscription-polymerase chain reactionShorter lifetime durationGene expressionParous womenClinicopathologic characteristicsEstrogen receptorHispanic ethnicitySeparate cohortHispanic womenElevated gene expressionLinear regression analysisLifetime historyYounger ageNeu receptorCancerBreastfeeding