2017
Differences in the immune microenvironment and genomic characteristics of TNBC in African American women compared to other races.
Szekely B, Safonov A, Karn T, Bhagwagar S, Killelea B, Silber A, Hatzis C, Pusztai L. Differences in the immune microenvironment and genomic characteristics of TNBC in African American women compared to other races. Journal Of Clinical Oncology 2017, 35: e13028-e13028. DOI: 10.1200/jco.2017.35.15_suppl.e13028.Peer-Reviewed Original ResearchTriple-negative breast cancerNon-AA patientsImmune microenvironmentAfrican American womenImmune signaturesNeoantigen loadImmune metagenesLower pathologic complete response (pCR) ratesPathologic complete response rateComplete response rateNegative breast cancerAmerican womenMann-Whitney U testSignificant differencesClonal heterogeneityTCGA data setsDeletion loadNeoadjuvant therapyLymphocyte countTIL countAA patientsOverall mutational loadHistologic tumorsBreast cancerTreatment response
2007
Breast Cancer
Ross J, Linette G, Stec J, Clark E, Ayers M, Symmans F, Hortobagyi G, Pusztai L. Breast Cancer. 2007, 269-278. DOI: 10.1007/978-0-387-33227-7_24.Peer-Reviewed Original ResearchBreast cancerInvasive breast cancerCurrent incidence ratesAmerican womenGenetic predisposition testingMicrometastasis detectionSitu diseaseClinical managementIncidence rateField of pharmacogenomicsRNA expression profilingNew casesPredisposition testingCancerMolecular pathologyBiomarker assaysSerum diagnosticsDiseaseWomenExpression profilingFuture assaysAssaysPathology