2005
Influence of Psychiatric Comorbidity on Recovery and Recurrence in Generalized Anxiety Disorder, Social Phobia, and Panic Disorder: A 12-Year Prospective Study
Bruce SE, Yonkers KA, Otto MW, Eisen JL, Weisberg RB, Pagano M, Shea MT, Keller MB. Influence of Psychiatric Comorbidity on Recovery and Recurrence in Generalized Anxiety Disorder, Social Phobia, and Panic Disorder: A 12-Year Prospective Study. American Journal Of Psychiatry 2005, 162: 1179-1187. PMID: 15930067, PMCID: PMC3272761, DOI: 10.1176/appi.ajp.162.6.1179.Peer-Reviewed Original ResearchConceptsComorbid psychiatric disordersClinical courseAnxiety disordersPanic disorderPsychiatric disordersHarvard/Brown Anxiety Disorders Research ProgramLong-term clinical courseProportional hazards regression analysisOverall clinical courseChronic clinical courseHazards regression analysisSocial phobiaComorbid psychiatric conditionsStandard survival analysis methodsGeneralized anxiety disorderLikelihood of recoveryChronic courseProspective studyMulticenter studyPsychiatric comorbidityRisk ratioMajor depressionRecurrencePsychiatric predictorsSurvival analysis
2003
Chronicity, relapse, and illness—course of panic disorder, social phobia, and generalized anxiety disorder: Findings in men and women from 8 years of follow‐up
Yonkers KA, Bruce SE, Dyck IR, Keller MB. Chronicity, relapse, and illness—course of panic disorder, social phobia, and generalized anxiety disorder: Findings in men and women from 8 years of follow‐up. Depression And Anxiety 2003, 17: 173-179. PMID: 12768651, DOI: 10.1002/da.10106.Peer-Reviewed Original ResearchConceptsHarvard/Brown Anxiety Research ProgramClinical courseRelapse rateUncomplicated panic disorderPanic disorderAnxiety disordersRelapse eventsSex differencesSocial phobiaCumulative remission rateMajority of menFrequent remissionsRemission ratePrognostic implicationsChronic illnessRelapse statusRemissionYears of observationPatientsEnduring illnessSame cohortSignificant sex differencesMonth intervalsIllnessObservation period