2001
Differential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro
Novotny E, Ariyan C, Mason G, O’Reilly J, Haddad G, Behar K. Differential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro. Brain Research 2001, 888: 193-202. PMID: 11150475, DOI: 10.1016/s0006-8993(00)03051-1.Peer-Reviewed Original ResearchConceptsGlucose oxidative metabolismNeocortical slicesOxidative metabolismRat postnatal developmentCortical glutamateCerebral cortexCortex maturesPostnatal dayPostnatal developmentAge groupsCortexMitochondrial TCA cycleGreater increaseVivoGlucose oxidationTCA cycle fluxDifferential increaseAcid extractsMetabolismSlicesDeafferentiationCycle fluxRats
1995
Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR
Mason G, Gruetter R, Rothman D, Behar K, Shulman R, Novotny E. Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR. Cerebrovascular And Brain Metabolism Reviews 1995, 15: 12-25. PMID: 7798329, DOI: 10.1038/jcbfm.1995.2.Peer-Reviewed Original Research
1994
Analysis of macromolecule resonances in 1H NMR spectra of human brain
Behar K, Rothman D, Spencer D, Petroff O. Analysis of macromolecule resonances in 1H NMR spectra of human brain. Magnetic Resonance In Medicine 1994, 32: 294-302. PMID: 7984061, DOI: 10.1002/mrm.1910320304.Peer-Reviewed Original Research
1989
Effects of Acute Hyperammonemia on Cerebral Amino Acid Metabolism and pHi In Vivo, Measured by 1H and 31P Nuclear Magnetic Resonance
Fitzpatrick S, Hetherington H, Behar K, Shulman R. Effects of Acute Hyperammonemia on Cerebral Amino Acid Metabolism and pHi In Vivo, Measured by 1H and 31P Nuclear Magnetic Resonance. Journal Of Neurochemistry 1989, 52: 741-749. PMID: 2563756, DOI: 10.1111/j.1471-4159.1989.tb02517.x.Peer-Reviewed Original ResearchConceptsAmmonia infusionCerebral amino acid metabolismCerebral glutamate levelsAcute intravenous infusionBrain glutamate concentrationsBrain lactate levelsMin of infusionContent of phosphocreatineBrain lactate contentGlutamine concentrationPreinfusion controlAcute hyperammonemiaIntravenous infusionCerebral glutamateControl infusionGlutamate levelsInfusion protocolArterial PCO2Lactate levelsPreinfusion valuesBrain glutamineBlood ammoniaMagnetic resonanceInfusionGlutamate concentration
1985
Effect of Hypoglycemic Encephalopathy upon Amino Acids, High‐Energy Phosphates, and pHi in the Rat Brain In Vivo: Detection by Sequential 1H and 31P NMR Spectroscopy
Behar K, Hollander J, Petroff O, Hetherington H, Prichard J, Shulman R. Effect of Hypoglycemic Encephalopathy upon Amino Acids, High‐Energy Phosphates, and pHi in the Rat Brain In Vivo: Detection by Sequential 1H and 31P NMR Spectroscopy. Journal Of Neurochemistry 1985, 44: 1045-1055. PMID: 2857770, DOI: 10.1111/j.1471-4159.1985.tb08723.x.Peer-Reviewed Original Research1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo.
Rothman D, Behar K, Hetherington H, Hollander J, Bendall M, Petroff O, Shulman R. 1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 1633-1637. PMID: 2858850, PMCID: PMC397326, DOI: 10.1073/pnas.82.6.1633.Peer-Reviewed Original Research
1984
Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo.
Rothman D, Behar K, Hetherington H, Shulman R. Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 6330-6334. PMID: 6149543, PMCID: PMC391917, DOI: 10.1073/pnas.81.20.6330.Peer-Reviewed Original ResearchDetection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T).
Behar K, Rothman D, Shulman R, Petroff O, Prichard J. Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T). Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 2517-2519. PMID: 6585812, PMCID: PMC345093, DOI: 10.1073/pnas.81.8.2517.Peer-Reviewed Original Research
1983
High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo.
Behar K, Hollander J, Stromski M, Ogino T, Shulman R, Petroff O, Prichard J. High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1983, 80: 4945-4948. PMID: 6576367, PMCID: PMC384164, DOI: 10.1073/pnas.80.16.4945.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexHeart RateHypoxiaKineticsLactatesLactic AcidMagnetic Resonance SpectroscopyRats