Human Brain γ‐Aminobutyric Acid Levels and Seizure Control Following Initiation of Vigabatrin Therapy
Petroff O, Behar K, Mattson R, Rothman D. Human Brain γ‐Aminobutyric Acid Levels and Seizure Control Following Initiation of Vigabatrin Therapy. Journal Of Neurochemistry 1996, 67: 2399-2404. PMID: 8931472, DOI: 10.1046/j.1471-4159.1996.67062399.x.Peer-Reviewed Original ResearchConceptsBrain GABA contentImproved seizure controlBrain GABA levelsSeizure controlVigabatrin treatmentGABA levelsDaily doseAntiepileptic drugsOccipital lobeBrain gamma-aminobutyric acid (GABA) concentrationsGABA concentrationHuman brain GABA levelsGABA contentGamma-aminobutyric acid concentrationΓ-aminobutyric acid (GABA) levelsComplex partial seizuresNovel antiepileptic drugBrain GABA concentrationsSeizure frequencyPartial seizuresVigabatrin therapySustained elevationHuman occipital lobeGABA synthesisAcid levelsLow brain GABA level is associated with poor seizure control
Petroff O, Rothman D, Behar K, Mattson R. Low brain GABA level is associated with poor seizure control. Annals Of Neurology 1996, 40: 908-911. PMID: 9007096, DOI: 10.1002/ana.410400613.Peer-Reviewed Original ResearchConceptsLower GABA levelsBrain GABA levelsLower brain GABA levelsPoor seizure controlGABA levelsSeizure controlRecent seizuresGamma-aminobutyric acid concentrationComplex partial seizuresPartial seizuresEpileptic syndromesEpileptic focusOccipital lobeCerebrospinal fluidPatientsSeizuresSignificant associationMagnetic resonanceVivo measurementsSurface coilLevelsEpilepsySyndromeGABAAcid concentration