2018
A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit
da Silva K, Maciel W, Croda J, Cayô R, Ramos A, de Sales R, Kurihara M, Vasconcelos N, Gales A, Simionatto S. A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit. PLOS ONE 2018, 13: e0209367. PMID: 30592758, PMCID: PMC6310363, DOI: 10.1371/journal.pone.0209367.Peer-Reviewed Original ResearchMeSH KeywordsAcinetobacter baumanniiAcinetobacter InfectionsAdultAgedAged, 80 and overAnti-Bacterial AgentsBacterial ProteinsBeta-LactamasesBrazilCase-Control StudiesCross InfectionDrug Resistance, Multiple, BacterialFemaleHospital MortalityHumansIntensive Care UnitsMaleMicrobial Sensitivity TestsMiddle AgedConceptsOXA-23-producing A. baumanniiHigh mortality rateA. baumanniiMortality rateRisk factorsHealthcare-related risk factorsBrazilian intensive care unitsIntensive care unit patientsIntensive care unit settingCarbapenem-resistant Acinetobacter baumanniiISAba1 insertion sequenceA. baumannii infectionsCare unit patientsIntensive care unitBlaOXA-51 geneUse of cephalosporinsCase-control studyBaumannii infectionsUnit patientsCare unitNasogastric tubeTherapeutic optionsUnit settingNosocomial infectionsSuch infections
2016
Impact of mass-screening on tuberculosis incidence in a prospective cohort of Brazilian prisoners
Paião DS, Lemos EF, Carbone AD, Sgarbi RV, Junior AL, da Silva FM, Brandão LM, dos Santos LS, Martins VS, Simionatto S, Motta-Castro AR, Pompílio MA, Urrego J, Ko AI, Andrews JR, Croda J. Impact of mass-screening on tuberculosis incidence in a prospective cohort of Brazilian prisoners. BMC Infectious Diseases 2016, 16: 533. PMID: 27716170, PMCID: PMC5048439, DOI: 10.1186/s12879-016-1868-5.Peer-Reviewed Original ResearchConceptsTuberculin skin testingActive tuberculosisRisk factorsSubsequent diseaseProspective cohort studyEarly case detectionHigh transmission settingsHigh-risk populationPotential risk factorsProportional hazards modelSubsequent disease riskMass screening interventionTST conversionCohort studyProspective cohortHIV testingTuberculosis infectionScreening interventionsSkin testingTB notificationsTuberculosis incidenceSubsequent riskCase detectionSputum samplesActive screeningFactors associated with anti-TB drug-induced hepatotoxicity and genetic polymorphisms in indigenous and non-indigenous populations in Brazil
Heinrich M, Zembrzuski V, Ota M, Sacchi F, Teixeira R, Acero P, Cunha G, Souza-Santos R, Croda J, Basta P. Factors associated with anti-TB drug-induced hepatotoxicity and genetic polymorphisms in indigenous and non-indigenous populations in Brazil. Tuberculosis 2016, 101: 15-24. PMID: 27865386, DOI: 10.1016/j.tube.2016.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntitubercular AgentsArylamine N-AcetyltransferaseBrazilChemical and Drug Induced Liver InjuryChildChild, PreschoolCross-Sectional StudiesCytochrome P-450 CYP2E1FemaleGenetic Predisposition to DiseaseGenotypeGlutathione TransferaseHumansIncidenceInfantLongitudinal StudiesMaleMiddle AgedPolymorphism, Single NucleotideTuberculosis, PulmonaryYoung AdultConceptsIncidence of hepatotoxicityAdverse drug reactionsIndigenous patientsAnti-TB drug-induced hepatotoxicityNon-conditional logistic regressionClinical-epidemiological factorsClinical-epidemiological variablesNon-Indigenous patientsGenetic polymorphismsRisk of hepatotoxicityDrug-induced hepatotoxicityPolymorphisms of CYP2E1Anti-tuberculosis drugsAcetylation profileTB patientsSerum levelsDrug reactionsGSTM1 polymorphismOdds ratioLiver enzymesNon-Indigenous populationsTherapeutic schemesPharmacogenetic analysisBetter outcomesPatients
2015
A Cross-Sectional Survey of HIV Testing and Prevalence in Twelve Brazilian Correctional Facilities
Sgarbi RV, da Silva Santos Carbone A, Paião DS, Lemos EF, Simionatto S, Puga MA, Motta-Castro AR, Pompilio MA, Urrego J, Ko AI, Andrews JR, Croda J. A Cross-Sectional Survey of HIV Testing and Prevalence in Twelve Brazilian Correctional Facilities. PLOS ONE 2015, 10: e0139487. PMID: 26466312, PMCID: PMC4605759, DOI: 10.1371/journal.pone.0139487.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnti-Retroviral AgentsBrazilCross-Sectional StudiesFemaleHealth Services AccessibilityHIV InfectionsHumansMaleMass ScreeningMiddle AgedMultivariate AnalysisOdds RatioPrevalencePrisonersPrisonsSurveys and QuestionnairesSyphilisVulnerable PopulationsYoung AdultConceptsHIV testingHIV careMental illnessMultivariable logistic regression modelPrevious HIV testingHIV testing ratesMajority of HIVHIV testing practicesTreatment of HIVHigh HIV prevalencePopulation-based samplePercent of participantsLogistic regression modelsAntiretroviral therapyHIV diagnosisPrevious surgeryHIV infectionHIV statusMultivariable analysisHIV prevalenceSyphilis testingClinical careGeneral populationHIVTesting ratesRisk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil
Druzian A, de Souza A, de Campos D, Croda J, Higa M, Dorval M, Pompilio M, de Oliveira P, Paniago A. Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil. PLOS Neglected Tropical Diseases 2015, 9: e0003982. PMID: 26274916, PMCID: PMC4537269, DOI: 10.1371/journal.pntd.0003982.Peer-Reviewed Original ResearchConceptsHIV/AIDSVisceral leishmaniasisRisk factorsAdult patientsMortality rateUrban endemic areaProspective cohort studySecondary bacterial infectionHigh mortality rateEndemic urban areaCohort studyEpidemiological profileMean ageUniversity HospitalEndemic areasMultivariate analysisPatientsBacterial infectionsAIDSDeathSignificant increaseHigh rateLeishmaniasisEdemaRelapseCoproduction of KPC-2 and IMP-10 in Carbapenem-Resistant Serratia marcescens Isolates from an Outbreak in a Brazilian Teaching Hospital
Silva K, Cayô R, Carvalhaes C, Sacchi F, Rodrigues-Costa F, da Silva A, Croda J, Gales A, Simionatto S. Coproduction of KPC-2 and IMP-10 in Carbapenem-Resistant Serratia marcescens Isolates from an Outbreak in a Brazilian Teaching Hospital. Journal Of Clinical Microbiology 2015, 53: 2324-2328. PMID: 25878341, PMCID: PMC4473237, DOI: 10.1128/jcm.00727-15.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnti-Bacterial AgentsBeta-Lactam ResistanceBeta-LactamasesBrazilCarbapenemsChild, PreschoolCross InfectionDisease OutbreaksDNA, BacterialFemaleGenes, BacterialHospitals, TeachingHumansInfantIntegronsMaleMicrobial Sensitivity TestsMiddle AgedMinocyclineMolecular Sequence DataPlasmidsSequence Analysis, DNASerratia InfectionsSerratia marcescensTigecyclineActive and latent tuberculosis in Brazilian correctional facilities: a cross-sectional study
Carbone Ada S, Paião DS, Sgarbi RV, Lemos EF, Cazanti RF, Ota MM, Junior AL, Bampi JV, Elias VP, Simionatto S, Motta-Castro AR, Pompílio MA, de Oliveira SM, Ko AI, Andrews JR, Croda J. Active and latent tuberculosis in Brazilian correctional facilities: a cross-sectional study. BMC Infectious Diseases 2015, 15: 24. PMID: 25608746, PMCID: PMC4307675, DOI: 10.1186/s12879-015-0764-8.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionPrevalence of LTBITuberculin skin testActive TBLTBI prevalenceWeeks of symptomsHigh transmission settingsCross-sectional studyPopulation-based samplePoisson regression modelsDuration of incarcerationHierarchical Poisson regression modelActive diseaseTB infectionLatent tuberculosisTB casesHIV testingSputum cultureTuberculosis infectionPoint prevalenceSkin testTuberculosis incidenceRisk factorsMultivariable modelSputum samples
2013
Evaluation of the traditional and revised world health organization classifications of dengue cases in Brazil
Lima F, Croda M, Muniz D, Gomes I, de Moraes Soares K, Cardoso M, Tauro R, Croda J. Evaluation of the traditional and revised world health organization classifications of dengue cases in Brazil. Clinics 2013, 68: 1299-1304. PMID: 24212835, PMCID: PMC3798712, DOI: 10.6061/clinics/2013(10)02.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAgedAged, 80 and overBrazilChildChild, PreschoolCross-Sectional StudiesDengueFemaleHospitalizationHospitals, UniversityHumansInfantIntensive Care UnitsMaleMedical RecordsMiddle AgedSeverity of Illness IndexSex DistributionWorld Health OrganizationYoung AdultConceptsCross-sectional studySevere dengueDengue feverRevised classification systemWorld Health Organization classificationWorldwide public health problemDengue hemorrhagic shockRisk of progressionRisk of complicationsDistribution of patientsDengue hemorrhagic feverPublic health problemWarning signsClassification systemWorld Health OrganizationClinical suspicionHemorrhagic shockOrganization classificationUniversity HospitalMedical recordsSevere diseaseHemorrhagic feverSevere casesPatientsClinical practice