2022
Serum biomarkers associated with SARS-CoV-2 severity
de Morais Batista F, Puga M, da Silva P, Oliveira R, dos Santos P, da Silva B, Tatara M, Tsuha D, dos Santos Pires M, Gonçalves C, Pessoa e Silva R, Ferreira N, de Barros Albuquerque A, da Silva Duarte G, Consolaro M, Negrão F, Ferrari I, de Goes Cavalcanti L, Trinta K, Ribeiro G, de Melo Rêgo M, Boyton R, Siqueira A, Altmann D, Croda J. Serum biomarkers associated with SARS-CoV-2 severity. Scientific Reports 2022, 12: 15999. PMID: 36163447, PMCID: PMC9511452, DOI: 10.1038/s41598-022-20062-5.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionSevere casesSARS-CoV-2 severityCytokine/chemokine productionImmune response profileBiological marker levelsSARS-CoV-2GDF-15Clinical courseAcute phaseChemokine productionD-dimerSICAM-1Marker levelsSerum biomarkersHeart diseasePrognostic markerCardiovascular diseaseGroup C.Angiogenesis markersGroup SPrognostic signatureGroup MP-selectinDisease severity
2013
Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review
Longhi R, Zembrzuski V, Basta P, Croda J. Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review. The Brazilian Journal Of Infectious Diseases 2013, 17: 363-368. PMID: 23665009, PMCID: PMC9427389, DOI: 10.1016/j.bjid.2012.11.001.Peer-Reviewed Original ResearchConceptsImmune responseCytokine expressionGenetic polymorphismsHigher IL-5 productionTh2-type responseIL-5 productionTuberculin skin testIFN-γ productionRelevant genetic polymorphismsActive diseaseTB infectionCytokine levelsLower TNFHigh IgG4IgM levelsIL-12p40Skin testImmunogenetic mechanismsImmune regulationInclusion criteriaNew treatmentsMajority of studiesTuberculosisSearch termsIndigenous populations
2008
Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection
Reis EA, Athanazio DA, Cavada BS, Teixeira EH, de Paulo Teixeira Pinto V, Carmo TM, Reis A, Trocolli G, Croda J, Harn D, Barral-Netto M, Reis MG. Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection. Acta Tropica 2008, 108: 160-165. PMID: 18579103, DOI: 10.1016/j.actatropica.2008.05.025.Peer-Reviewed Original ResearchConceptsPatients' peripheral blood mononuclear cellsPeripheral blood mononuclear cellsCytokine productionElevated IL-5 productionTh2-like cytokine responseIL-5 productionSchistosoma mansoni infectionStimulation ex vivoTh2-like responseBlood mononuclear cellsPotential immunomodulatory effectsSoluble egg antigenExperimental murine modelTh2 environmentPBMC supernatantsIL-10Mansoni infectionCytokine responsesEgg antigenImmunomodulatory effectsMononuclear cellsInfected patientsIL-5TNF-alphaLymphocyte stimulator