2022
Serum biomarkers associated with SARS-CoV-2 severity
de Morais Batista F, Puga M, da Silva P, Oliveira R, dos Santos P, da Silva B, Tatara M, Tsuha D, dos Santos Pires M, Gonçalves C, Pessoa e Silva R, Ferreira N, de Barros Albuquerque A, da Silva Duarte G, Consolaro M, Negrão F, Ferrari I, de Goes Cavalcanti L, Trinta K, Ribeiro G, de Melo Rêgo M, Boyton R, Siqueira A, Altmann D, Croda J. Serum biomarkers associated with SARS-CoV-2 severity. Scientific Reports 2022, 12: 15999. PMID: 36163447, PMCID: PMC9511452, DOI: 10.1038/s41598-022-20062-5.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionSevere casesSARS-CoV-2 severityCytokine/chemokine productionImmune response profileBiological marker levelsSARS-CoV-2GDF-15Clinical courseAcute phaseChemokine productionD-dimerSICAM-1Marker levelsSerum biomarkersHeart diseasePrognostic markerCardiovascular diseaseGroup C.Angiogenesis markersGroup SPrognostic signatureGroup MP-selectinDisease severity
2007
Leptospira Immunoglobulin-Like Proteins as a Serodiagnostic Marker for Acute Leptospirosis
Croda J, Ramos JG, Matsunaga J, Queiroz A, Homma A, Riley LW, Haake DA, Reis MG, Ko AI. Leptospira Immunoglobulin-Like Proteins as a Serodiagnostic Marker for Acute Leptospirosis. Journal Of Clinical Microbiology 2007, 45: 1528-1534. PMID: 17360842, PMCID: PMC1865864, DOI: 10.1128/jcm.02344-06.Peer-Reviewed Original ResearchConceptsSerodiagnostic markerDays of illnessLarge disease burdenLeptospira immunoglobulin-like proteinAcute infectionClinical presentationAcute leptospirosisIgM antibodiesAntibody responseDisease burdenPutative virulence determinantsIgM enzymeTimely diagnosisSevere formHealthy individualsMicroagglutination testPatientsUrban outbreaksHigh mortalityInfectious diseasesPathogenic serovarsLeptospirosisImmunosorbent assaySerumSpecific markers