2024
Serial Mass Screening for Tuberculosis Among Incarcerated Persons in Brazil
de Araujo R, Martinez L, da Silva Santos A, Lemos E, de Oliveira R, Croda M, Silva D, Lemes I, Cunha E, Gonçalves T, dos Santos P, da Silva B, Gonçalves C, Andrews J, Croda J. Serial Mass Screening for Tuberculosis Among Incarcerated Persons in Brazil. Clinical Infectious Diseases 2024, 78: 1669-1676. PMID: 38324908, PMCID: PMC11175667, DOI: 10.1093/cid/ciae055.Peer-Reviewed Original ResearchScreening roundsIncarcerated personsMass screeningIndividual prisonersIncarcerated peoplePrison populationBrazilian prisonsCases of pulmonary tuberculosisHigh-risk populationPrisonHealth QuestionnaireChest X-rayImprove case detectionPrevalence of tuberculosisRate of tuberculosisTB screeningMedian scoreHyperendemic settingsPulmonary tuberculosisXpert MTB/RIFTB scoreTuberculosis casesTuberculosis burdenCase detectionTuberculosis
2022
Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis
Martinez L, Cords O, Liu Q, Acuna-Villaorduna C, Bonnet M, Fox G, Carvalho A, Chan P, Croda J, Hill P, Lopez-Varela E, Donkor S, Fielding K, Graham S, Espinal M, Kampmann B, Reingold A, Huerga H, Villalba J, Grandjean L, Sotgiu G, Egere U, Singh S, Zhu L, Lienhardt C, Denholm J, Seddon J, Whalen C, García-Basteiro A, Triasih R, Chen C, Singh J, Huang L, Sharma S, Hannoun D, Del Corral H, Mandalakas A, Malone L, Ling D, Kritski A, Stein C, Vashishtha R, Boulahbal F, Fang C, Boom W, Netto E, Lemos A, Hesseling A, Kay A, Jones-López E, Horsburgh C, Lange C, Andrews J. Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis. The Lancet Global Health 2022, 10: e1307-e1316. PMID: 35961354, PMCID: PMC10406427, DOI: 10.1016/s2214-109x(22)00283-2.Peer-Reviewed Original ResearchConceptsInfant BCG vaccinationBCG vaccinationExtrapulmonary tuberculosisCohort studyIndividual participant dataPulmonary tuberculosisParticipant dataSystematic reviewIndividual-level participant dataPositive tuberculin skin testMultivariable logistic regression analysisTuberculin skin testTuberculosis infection statusParticipant-level dataLogistic regression analysisAge-specific impactStudy-level random effectWeb of ScienceIncident tuberculosisPrevious tuberculosisTuberculosis developmentSecondary outcomesTuberculosis contactsPrimary outcomeSkin testTuberculosis in prison inmates in Southern Brazil: investigating the epidemiological and operational indicators
Busatto C, Mespaque J, Schwarzbold P, de Souza C, Jarczewski C, Meucci R, Andrews J, Croda J, da Silva P, Ramis I, Possuelo L. Tuberculosis in prison inmates in Southern Brazil: investigating the epidemiological and operational indicators. Revista Da Sociedade Brasileira De Medicina Tropical 2022, 55: e0052-2022. PMID: 36287468, PMCID: PMC9592108, DOI: 10.1590/0037-8682-0052-2022.Peer-Reviewed Original ResearchConceptsPulmonary tuberculosis casesTuberculosis casesPulmonary tuberculosisLaboratory confirmationNew casesNew pulmonary tuberculosis casesRetreatment pulmonary tuberculosis casesWorldwide public health problemNotifiable Diseases Information SystemNew TB casesPublic health problemPublic health measuresTB casesHIV testingTuberculosis controlLaboratory criteriaTuberculosis incidenceIncidence rateObservational studyHealth problemsHealth measuresTuberculosisSpecific populationsHIVInvestigation rates
2021
A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment.
Verma R, Patil S, Zhang N, Moreira F, Vitorio M, Santos A, Wallace E, Gnanashanmugam D, Persing D, Savic R, Croda J, Andrews J. A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 1317-1326. PMID: 34375564, DOI: 10.1164/rccm.202103-0564oc.Peer-Reviewed Original ResearchConceptsPharmacogenomic assaysSparse pharmacokinetic samplingInadequate treatment responseInterindividual pharmacokinetic variabilityAcetylation genotypeIsoniazid clearancePharmacokinetic samplingPulmonary tuberculosisWhole blood samplesIntermediate acetylatorsPharmacokinetic variabilityFast acetylatorsNAT2 polymorphismsAcetylator typeSlow acetylatorsTuberculosis treatmentTreatment responseBlood samplesGeneXpert platformTuberculosis diagnosisVariable drug concentrationsHealthy individualsPersonalized dosingSubstantial incidenceStandardized dosingBlood-based host biomarker diagnostics in active case finding for pulmonary tuberculosis: A diagnostic case-control study
Moreira F, Verma R, dos Santos P, Leite A, da Silva Santos A, de Araujo R, da Silva B, de Sá Queiroz J, Persing D, Södersten E, Gnanashanmugam D, Khatri P, Croda J, Andrews J. Blood-based host biomarker diagnostics in active case finding for pulmonary tuberculosis: A diagnostic case-control study. EClinicalMedicine 2021, 33: 100776. PMID: 33842866, PMCID: PMC8020164, DOI: 10.1016/j.eclinm.2021.100776.Peer-Reviewed Original ResearchCare C-reactive proteinXpert MTB/RIFMTB/RIFDiagnostic case-control studyXpert MTBCase-control studyTuberculosis casesTriage testSputum Xpert MTB/RIFHigh tuberculosis burden settingsActive casesSputum bacillary burdenC-reactive proteinHigh-burden populationsCulture-confirmed casesMass screening programCulture-negative controlsBacillary burdenTuberculosis symptomsPulmonary tuberculosisSputum cultureScreening program
2020
Oral swab testing by Xpert® MTB/RIF Ultra for mass tuberculosis screening in prisons
Lima F, Santos A, Oliveira R, Silva C, Gonçalves C, Andrews J, Croda J. Oral swab testing by Xpert® MTB/RIF Ultra for mass tuberculosis screening in prisons. Journal Of Clinical Tuberculosis And Other Mycobacterial Diseases 2020, 19: 100148. PMID: 32099908, PMCID: PMC7031315, DOI: 10.1016/j.jctube.2020.100148.Peer-Reviewed Original ResearchNucleic acid amplification testsOral swabsPulmonary tuberculosisSwab testingAmplification testsMTB/RIF UltraMass screening studyOral swab samplingCourse of illnessScreening studySputum cultureXpert testingBacillary loadMycobacterial loadCase findingSputumXpertSwabsTuberculosisFurther studiesSwab samplingParticipantsComparable sensitivityPrison inmatesIndividualsSpirometry results after treatment for pulmonary tuberculosis: comparison between patients with and without previous lung disease: a multicenter study
Mancuzo E, Martins E, Sulmonett N, de Souza Viana V, Croda J, Kritski A, de Queiroz Mello F, de Souza Elias Nihues S, Azevedo K, de Miranda S. Spirometry results after treatment for pulmonary tuberculosis: comparison between patients with and without previous lung disease: a multicenter study. Jornal Brasileiro De Pneumologia 2020, 46: e20180198. PMID: 32130330, PMCID: PMC7462712, DOI: 10.36416/1806-3756/e20180198.Peer-Reviewed Original ResearchConceptsPrevious lung diseasePulmonary tuberculosisLung diseaseRadiological changesMulticenter studyRisk factorsLDS groupFunctional severityFunctional changesSevere radiological changesImpaired pulmonary functionRestrictive lung diseaseObstructive lung diseaseDegree of dyspneaChest X-raySpirometric changesSevere dyspneaPulmonary functionReferral centerClinical dataPatientsSpirometryDiseaseDyspneaSmoking
2018
Building capacity for advances in tuberculosis research; proceedings of the third RePORT international meeting
van der Heijden Y, Abdullah F, Andrade B, Andrews J, Christopher D, Croda J, Ewing H, Haas D, Hatherill M, Horsburgh C, Mave V, Nakaya H, Rolla V, Srinivasan S, Sugiyono R, Ugarte-Gil C, Hamilton C. Building capacity for advances in tuberculosis research; proceedings of the third RePORT international meeting. Tuberculosis 2018, 113: 153-162. PMID: 30514497, PMCID: PMC6349374, DOI: 10.1016/j.tube.2018.09.009.Peer-Reviewed Original ResearchConceptsType 2 diabetes mellitusTuberculosis researchActive pulmonary tuberculosisHigh-risk populationEnrollment of participantsContext of HIVUnderstanding of tuberculosisHousehold contactsActive tuberculosisObservational cohortPulmonary tuberculosisDiabetes mellitusTuberculosis transmissionClinical dataIncipient tuberculosisNovel biomarkersTB participantsHost immunityStandardized research protocolsTuberculosisResearch capacity developmentHIVResearch protocolBiomarker identificationInternational meetings