2017
Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol
do Nascimento K, Moreira F, Santos J, Kassuya C, Croda J, Cardoso C, do Carmo Vieira M, Ruiz A, Foglio M, de Carvalho J, Formagio A. Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol. Journal Of Ethnopharmacology 2017, 210: 351-358. PMID: 28844678, DOI: 10.1016/j.jep.2017.08.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsAntineoplastic Agents, PhytogenicAntioxidantsAntitubercular AgentsCell Line, TumorCell ProliferationDisease Models, AnimalEdemaFemaleGas Chromatography-Mass SpectrometryHumansInhibitory Concentration 50MaleMiceOils, VolatilePlant ExtractsPlant LeavesPleurisyPsidiumRatsRats, WistarSesquiterpenesConceptsGas chromatography-mass spectrometryNuclear magnetic resonanceAntimycobacterial activityModerate antimycobacterial activityChromatography-mass spectrometryAnti-inflammatory effectsOvarian cancer cell linesAnti-inflammatory potentialAnti-Mycobacterium tuberculosis activityPsidium guineense SwEssential oilCancer cell linesSulforhodamine B assayChromatographic columnPG-1Pleurisy modelInflammatory diseasesOral administrationAntioxidant activityAntimycobacterial propertiesREMA methodTuberculosis activityB assaySignificant inhibitionCell proliferation
2016
Synthesis, in vitro Antiproliferative and Anti-Mycobacterium tuberculosis Activities of Novel β-Carboline Derivatives
Moreira F, Croda J, Sarragiotto M, Foglio M, Ruiz A, Carvalho J, Formagio A. Synthesis, in vitro Antiproliferative and Anti-Mycobacterium tuberculosis Activities of Novel β-Carboline Derivatives. Journal Of The Brazilian Chemical Society 2016, 27: 1398-1405. DOI: 10.5935/0103-5053.20160062.Peer-Reviewed Original ResearchM. tuberculosisNCI/ADRNCI/ADR cellsCell linesAnti-Mycobacterium tuberculosis activityCancer cell linesHuman cancer cell linesAnti-Mycobacterium tuberculosisΒ-carbolinesTumor cell linesGrowth inhibitory activityADR cellsTuberculosis activityOral bioavailabilityHuman tumor cell linesTerminal guanidine groupTuberculosisΒ-carboline derivativesInhibitory activityAntiproliferative activitySignificant activityGreater activityNovel β-carboline derivativesSilico studiesGroup