2002
Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies
Askanase A, Friedman D, Copel J, Dische M, Dubin A, Starc T, Katholi M, Buyon J. Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies. Lupus 2002, 11: 145-151. PMID: 11999879, DOI: 10.1191/0961203302lu173oa.Peer-Reviewed Original ResearchConceptsSSA/Ro-SSB/La antibodiesThird-degree blockCongenital heart blockLa antibodiesSecond-degree blockConduction abnormalitiesDegree blockNeonatal lupusHeart blockAV blockAtrial rateAV nodeAntibody-mediated inflammationMean atrial rateAdvanced AV blockTime of surgeryFirst-degree blockSpectrum of arrhythmiasNormal sinus rhythmAge 10 yearsIncomplete AV blockCardiac manifestationsNodal involvementSinus bradycardiaSubsequent fibrosis
2001
Anti‐Ro/SSA antibodies and congenital heart block: Necessary but not sufficient
Buyon J, Kim M, Copel J, Friedman D. Anti‐Ro/SSA antibodies and congenital heart block: Necessary but not sufficient. Arthritis & Rheumatism 2001, 44: 1723-1727. PMID: 11508420, DOI: 10.1002/1529-0131(200108)44:8<1723::aid-art305>3.0.co;2-0.Peer-Reviewed Original Research
1994
Relationship between maternal and neonatal levels of antibodies to 48 kDa SSB(La), 52 kDa SSA(Ro), and 60 kDa SSA(Ro) in pregnancies complicated by congenital heart block.
Buyon J, Waltuck J, Caldwell K, Crawford B, Slade S, Copel J, Chan E. Relationship between maternal and neonatal levels of antibodies to 48 kDa SSB(La), 52 kDa SSA(Ro), and 60 kDa SSA(Ro) in pregnancies complicated by congenital heart block. The Journal Of Rheumatology 1994, 21: 1943-50. PMID: 7837164.Peer-Reviewed Original ResearchConceptsCongenital heart blockAnti-60Heart blockCirculation of neonatesRatios of maternalUmbilical cord levelsTotal IgG levelsMean ratioAnti-52Neonatal circulationCord levelIgG levelsMaternal antibodiesSerum levelsNeonatal levelsUnaffected pregnanciesControl groupPregnancyFetal tissuesSelective depletionAntibodiesAutoantibodiesIndirect evidenceGroupNeonates
1993
Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children. comparison of enzyme‐linked immunosorbent assay and immunoblot for measurement of anti–ss‐a/ro and anti–ss‐b/la antibodies
Buyon J, Winchester R, Slade S, Arnett F, Copel J, Friedman D, Lockshin M. Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children. comparison of enzyme‐linked immunosorbent assay and immunoblot for measurement of anti–ss‐a/ro and anti–ss‐b/la antibodies. Arthritis & Rheumatism 1993, 36: 1263-1273. PMID: 8216420, DOI: 10.1002/art.1780360911.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayNeonatal lupus syndromeNeonatal lupusCongenital heart blockHeart blockSDS-immunoblotRo antibodiesHealthy infantsMothers of childrenLupus syndromeLa antibodiesFetal deathAutoimmune diseasesRo antigenRo responseDetectable cardiac involvementFetal death groupSystemic lupus erythematosusSpecific antibody profileMothers of infantsRelated autoimmune diseasesIdentification of mothersEnzyme-linked immunosorbentFine specificity patternsGroups of mothers