2000
Splenic artery Doppler peak systolic velocity predicts severe fetal anemia in rhesus disease
Bahado-Singh R, Oz U, Deren O, Kovanchi E, Hsu C, Copel J, Mari G. Splenic artery Doppler peak systolic velocity predicts severe fetal anemia in rhesus disease. American Journal Of Obstetrics And Gynecology 2000, 182: 1222-1226. PMID: 10819862, DOI: 10.1016/s0002-9378(00)70189-x.Peer-Reviewed Original ResearchConceptsDoppler peak systolic velocityPeak systolic velocitySevere anemiaSystolic velocityPrior transfusionsGestational ageHemoglobin deficitStudy groupSplenic artery peak systolic velocityMean peak systolic velocityPeak systolic velocity valuesMean gestational ageOverall study groupSevere fetal anemiaCord blood specimensSystolic velocity valuesNonhydropic fetusesMean hemoglobinRhesus diseaseFetal anemiaFetal hydropsStudy populationBlood specimensNormal fetusesFirst such reportNoninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization
Mari G, Deter R, Carpenter R, Rahman F, Zimmerman R, Moise K, Dorman K, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel J, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell S. Noninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization. New England Journal Of Medicine 2000, 342: 9-14. PMID: 10620643, DOI: 10.1056/nejm200001063420102.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityBlood Group IncompatibilityCordocentesisErythroblastosis, FetalErythrocytesFemaleFetal BloodGestational AgeHemoglobinsHumansInfant, NewbornIsoantibodiesMiddle Cerebral ArteryPregnancyPregnancy Complications, HematologicProspective StudiesReference ValuesRh IsoimmunizationROC CurveSensitivity and SpecificityUltrasonography, Doppler, PulsedUltrasonography, PrenatalConceptsMaternal red cell alloimmunizationRed cell alloimmunizationMiddle cerebral arterySystolic blood flowCerebral arteryBlood flowSevere anemiaFetal anemiaDoppler ultrasonographyNormal fetusesHemoglobin concentrationFetal middle cerebral arteryPeak velocityFetal hemoglobin concentrationAbsence of hydropsPeak systolic velocityGestational ageModerate anemiaSystolic velocityHemoglobin valuesMild anemiaInvasive techniquesAlloimmunizationAnemiaArtery
1997
Increase of fetal hematocrit decreases the middle cerebral artery peak systolic velocity in pregnancies complicated by rhesus alloimmunization
Mari G, Rahman F, Olofsson P, Ozcan T, Copel J. Increase of fetal hematocrit decreases the middle cerebral artery peak systolic velocity in pregnancies complicated by rhesus alloimmunization. The Journal Of Maternal-Fetal Medicine 1997, 6: 206-208. PMID: 9260116, DOI: 10.1002/(sici)1520-6661(199707/08)6:4<206::aid-mfm3>3.0.co;2-n.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery peak systolic velocityPeak systolic velocitySystolic velocityFetal hematocritTime of studyIntrauterine transfusionRed blood cellsFetal anemiaRhesus alloimmunizationGestational ageRh alloimmunizationDoppler ultrasoundBlood cellsHematocritAlloimmunizationPregnancyT-testP-valueDoppler measurementsStatistical comparisonTransfusionAnemiaDiagnosis
1995
Management of the Rh-Sensitizeo Mother
Gollin Y, Copel J. Management of the Rh-Sensitizeo Mother. Clinics In Perinatology 1995, 22: 545-559. PMID: 8521681, DOI: 10.1016/s0095-5108(18)30268-9.ChaptersMeSH KeywordsAnemiaFemaleFetal DiseasesHumansPregnancyPregnancy Complications, HematologicRh IsoimmunizationRisk FactorsConceptsRh immune globulinManagement of complicationsRh D typingEarly referralIntrauterine transfusionImmune globulinRh isoimmunizationTertiary centerAnemic fetusesNeonatal careFetal bloodInvasive techniquesLung maturityPrompt identificationD typingClinical situationsOptimal managementFetusesMothersTransfusionComplicationsIsoimmunizationNeonatesNeonatologistsPerinatologistsDiagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization
Mari G, Adrignolo A, Abuhamad A, Pirhonen J, Jones D, Ludomirsky A, Copel J. Diagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization. Ultrasound In Obstetrics And Gynecology 1995, 5: 400-405. PMID: 7552802, DOI: 10.1046/j.1469-0705.1995.05060400.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemia, HemolyticBlood Flow VelocityBlood Group AntigensCerebral ArteriesCordocentesisErythroblastosis, FetalFemaleFetal BloodGestational AgeHumansInfant, NewbornObserver VariationPregnancyProspective StudiesRetrospective StudiesRh IsoimmunizationROC CurveTransfusion ReactionUltrasonography, Doppler, ColorUltrasonography, Doppler, PulsedUltrasonography, PrenatalConceptsMiddle cerebral artery peak systolic velocityPeak systolic velocitySystolic velocityFetal anemiaGroup AAnemic fetusesMiddle cerebral artery peak systolic velocity valuesMiddle cerebral artery peak velocityFetal middle cerebral artery peak systolic velocityPeak systolic velocity valuesSystolic velocity valuesPeak velocityNormal mean valueAnemia riskNon-invasive methodGroup B.Prospective fashionFetal hematocritGroup BDoppler ultrasoundGroup CNormal fetusesAnemiaFetusesNormal valuesThe predictive value of maternal serum testing for detection of fetal anemia in red blood cell alloimmunization
Moise K, Perkins J, Sosler S, Brown S, Saade G, Carpenter R, Thorp J, Ludomirski A, Wilkins I, Grannum P, Copel J. The predictive value of maternal serum testing for detection of fetal anemia in red blood cell alloimmunization. American Journal Of Obstetrics And Gynecology 1995, 172: 1003-1009. PMID: 7892839, DOI: 10.1016/0002-9378(95)90034-9.Peer-Reviewed Original ResearchConceptsRed blood cell alloimmunizationFetal anemiaMarsh scoreReceiver operator characteristic curveCoombs titersRed blood cell antibodiesMaternal antibody titersGroups of fetusesMaternal serum testingCharacteristic curveMaternal serum testsMaternal titersCell antibodiesAntigen statusGestational agePregnant womenAntibody titersSerum testingSerum testFetal hematocritInvasive testingFetal bloodKruskal-Wallis testAnemiaFetal disease
1993
Erythropoietin in human fetuses with immune hemolytic anemia and hydrops fetalis.
Moya F, Grannum P, Widness J, Clemons G, Copel J, Hobbins J. Erythropoietin in human fetuses with immune hemolytic anemia and hydrops fetalis. Obstetrics And Gynecology 1993, 82: 353-8. PMID: 8355933.Peer-Reviewed Original ResearchConceptsRh isoimmunizationGestational agePlasma erythropoietinWeeks' gestationElective cesareanControl fetusesImmune hemolytic anemiaUmbilical cord plasmaHigh erythropoietin levelsUmbilical cord bloodCord plasmaLower hemoglobinInverse associationTerm fetusesCord bloodErythropoietin levelsHemolytic anemiaErythropoietin measurementsLate gestationHuman fetusesGestationFetusesIsoimmunizationAnemiaHemoglobin
1991
Alloimmune disorders and pregnancy.
Copel J, Gollin Y, Grannum P. Alloimmune disorders and pregnancy. Seminars In Perinatology 1991, 15: 251-6. PMID: 1656530.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1989
Fetal cardiac output in the isoimmunized pregnancy: A pulsed Doppler-echocardiographic study of patients undergoing intravascular intrauterine transfusion
Copel J, Grannum P, Green J, Belanger K, Hanna N, Jaffe C, Hobbins J, Kleinman C. Fetal cardiac output in the isoimmunized pregnancy: A pulsed Doppler-echocardiographic study of patients undergoing intravascular intrauterine transfusion. American Journal Of Obstetrics And Gynecology 1989, 161: 361-365. PMID: 2504042, DOI: 10.1016/0002-9378(89)90520-6.Peer-Reviewed Original ResearchConceptsCardiac outputAnemic fetusesIsoimmunized pregnanciesCombined ventricular outputDoppler echocardiographic studyFetal cardiac outputHigh output stateHigh cardiac outputIntravascular intrauterine transfusionSevere isoimmunizationCardiac indexIntrauterine transfusionIntravascular transfusionWeeks' gestationVentricular outputDoppler assessmentAge-specific normsControl fetusesHydrops fetalisControl groupMechanisms of developmentFetusesUnaffected fetusesTransfusionPregnancyPulsed Doppler flow-velocity waveforms in the prediction of fetal hematocrit of the severely isoimmunized pregnancy
Copel J, Grannum P, Green J, Belanger K, Hobbins J. Pulsed Doppler flow-velocity waveforms in the prediction of fetal hematocrit of the severely isoimmunized pregnancy. American Journal Of Obstetrics And Gynecology 1989, 161: 341-344. PMID: 2504040, DOI: 10.1016/0002-9378(89)90516-4.Peer-Reviewed Original Research
1988
Diagnostic fetal umbilical blood sampling in the management of isoimmunization
Reece E, Copel J, Scioscia A, Grannum P, DeGennaro N, Hobbins J. Diagnostic fetal umbilical blood sampling in the management of isoimmunization. American Journal Of Obstetrics And Gynecology 1988, 159: 1057-1062. PMID: 3142263, DOI: 10.1016/0002-9378(88)90412-7.Peer-Reviewed Original ResearchConceptsAntigen-positive fetusesFetal hemolytic diseaseFetal umbilical bloodManagement of isoimmunizationEarlier gestational ageMultiple invasive proceduresIsoimmunized pregnanciesFetal anemiaAntigen statusGestational ageUmbilical bloodHemolytic diseaseFetal bloodInvasive proceduresCurrent managementFetusesPreliminary reportPregnancyIsoimmunizationDiseaseManagement protocolDiagnosisBloodLittle riskTreatmentPrevention of Rh isoimmunization and treatment of the compromised fetus.
Grannum P, Copel J. Prevention of Rh isoimmunization and treatment of the compromised fetus. Seminars In Perinatology 1988, 12: 324-35. PMID: 3146812.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsBlood Transfusion, IntrauterineErythroblastosis, FetalFemaleFetal DeathHumansHydrops FetalisInfant, NewbornPregnancyRh IsoimmunizationConceptsFetal liver functionIntrauterine intravascular transfusionReversal of hydropsCorrection of anemiaWeeks of gestationSevere erythroblastosis fetalisNeonatal exchange transfusionProblems of prematurityNeonatal morbidityErythroblastosis fetalisIntravascular transfusionRh isoimmunizationExchange transfusionLiver functionFetal vasculatureIntravascular treatmentSevere diseaseTreatment teamPrompt correctionCentral veinTreatment centersTransfusionDifficult procedureTreatmentIsoimmunization