New Down syndrome screening algorithm: Ultrasonographic biometry and multiple serum markers combined with maternal age
Bahado-Singh R, Oz A, Kovanci E, Deren O, Copel J, Baumgarten A, Mahoney J. New Down syndrome screening algorithm: Ultrasonographic biometry and multiple serum markers combined with maternal age. American Journal Of Obstetrics And Gynecology 1998, 179: 1627-1631. PMID: 9855608, DOI: 10.1016/s0002-9378(98)70036-5.Peer-Reviewed Original ResearchConceptsHumerus length measurementsSerum markersDown syndromeMaternal ageTriple screenHumerus lengthMultiple stepwise logistic regression analysisTriple-marker serum screeningSerum analytesStepwise logistic regression analysisScreening algorithmHigh-risk populationFetal Down syndromeMultiple serum markersDown syndrome screeningHuman chorionic gonadotropinLogistic regression analysisNew screening algorithmDown's syndrome screening efficiencyPrenatal Down syndrome screeningDown syndrome detectionFalse positive rateSerum screenSingleton fetusesUnconjugated estriolAn alternative for women initially declining genetic amniocentesis: Individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers
Bahado-Singh R, Deren O, Oz U, Tan A, Hunter D, Copel J, Mahoney M. An alternative for women initially declining genetic amniocentesis: Individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers. American Journal Of Obstetrics And Gynecology 1998, 179: 514-519. PMID: 9731862, DOI: 10.1016/s0002-9378(98)70388-6.Peer-Reviewed Original ResearchConceptsHyperechoic fetal bowelMaternal ageDown syndromeFetal bowelUltrasonographic parametersScreen-positive rateSignificant independent predictorsAge-related riskDown syndrome riskIndividual oddsLikelihood ratioPositive predictive valueHypoplastic fifth digitDigit hypoplasiaWeeks' gestationIndependent predictorsNormal medianIndividual Down syndrome oddsSingleton fetusesSyndrome riskUltrasonographic markersSerum screeningGenetic amniocentesisHigh riskNuchal thickening